Results 91 to 100 of about 46,429 (222)
Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception [PDF]
, 2004 Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating ...
DiPirro, Jean M., Kristal, Dr. Mark B.
core
Multi-Overlap Simulations for Transitions between Reference Configurations
, 2003 We introduce a new procedure to construct weight factors, which flatten the probability density of the overlap with respect to some pre-defined reference configuration.
A. Mitsutake +28 more
core +1 more source
Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]
, 2012 Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas +7 more
core +2 more sources
Chemistry &Biodiversity, Volume 22, Issue 10, October 2025.Endophytic fungi of P. auritum were evaluated for their ability to produce inhibitors of formation of advanced glycation end products (AGEs). Neopestalotiopsis sp. H2 and Diaporthe sp. H5 extracts were the most active. So, we performed their chemical profiling by untargeted and phenolics‐targeted metabolomic approaches to identify the potential ...
Lory Sthephany Rochín‐Hernández +3 more
wiley +1 more source
Replica-Exchange Simulated Tempering Method for Simulations of Frustrated Systems
, 2000 We propose a new method for the determination of the weight factor for the simulated tempering method. In this method a short replica-exchange simulation is performed and the simulated tempering weight factor is obtained by the multiple-histogram ...
Ayori Mitsutake +31 more
core +1 more source
Journal of Comparative Neurology, Volume 533, Issue 10, October 2025.In the dorsal telencephalon of gobiiform fishes, there is a conspicuously organized structure, consisting of readily identifiable subregions that are surrounded by layers of cell bodies. Using immunohistochemistry against several antigen targets in this structure, we demonstrate that each of these subregions is characterized by its own individual ...
Ruth Gutjahr +2 more
wiley +1 more source
On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]
, 2013 The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F +6 more
core +3 more sources
Clinical and Public Health Guidelines, Volume 2, Issue 4, October 2025.ABSTRACT Introduction Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is common. Inconsistent recommendations among clinical practice guidelines for management of chronic pain contribute to suboptimal patient management.
Andrea J. Darzi +48 more
wiley +1 more source
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 10, October 2025.Three‐dimensional (3D) bioprinting is revolutionizing drug delivery and regenerative medicine by enabling personalized, controlled‐release therapeutic systems. This review explores advancements in biocompatible bioinks, nanomedicines, and 3D‐printed drug delivery constructs, including scaffolds, implants, and bioactive hydrogels.
Khonzisizwe Somandi, Yahya E. Choonara
wiley +1 more source
The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential
Frontiers in Molecular Neuroscience, 2017 Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease.
Johannes Burtscher, Christoph Schwarzer
doaj +1 more source