Results 31 to 40 of about 42,525 (258)
Frontiers in Physiology, 2023 The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec +1 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2011 Exposure to psychostimulants increases brain-derived neurotrophic factor (BDNF) mRNA and protein levels in the cerebral cortex and subcortical structures.
Jacqueline F McGinty +3 more
doaj +1 more source
Involvement of the Opioid Peptide Family in Cancer Progression
Biomedicines, 2023 Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez +2 more
doaj +1 more source
THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]
British Journal of Pharmacology, 1977 A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
Jeffery Hughes +2 more
openaire +5 more sources
Frontiers in Molecular Neuroscience, 2018 The adaptation to chronic stress is highly variable across individuals. Resilience to stress is a complex process recruiting various brain regions and neurotransmitter systems. The aim of this study was to investigate the involvement of endogenous opioid
Mathilde S. Henry +10 more
doaj +1 more source
An Effective and Safe Enkephalin Analog for Antinociception
Pharmaceutics, 2021 Opioids account for 69,000 overdose deaths per annum worldwide and cause serious side effects. Safer analgesics are urgently needed. The endogenous opioid peptide Leu-Enkephalin (Leu-ENK) is ineffective when introduced peripherally due to poor stability ...
K. K. DurgaRao Viswanadham +13 more
doaj +1 more source
Striatal Neuropeptides Enhance Selection and Rejection of Sequential Actions
Frontiers in Computational Neuroscience, 2017 The striatum is the primary input nucleus for the basal ganglia, and receives glutamatergic afferents from the cortex. Under the hypothesis that basal ganglia perform action selection, these cortical afferents encode potential “action requests.” Previous
David Buxton +3 more
doaj +1 more source
eLife, 2021 Functional interactions between G protein-coupled receptors are poised to enhance neuronal sensitivity to neuromodulators and therapeutic drugs. Mu and delta opioid receptors (MORs and DORs) can interact when overexpressed in the same cells, but whether ...
Xinyi Jenny He +5 more
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Degrees of freedom effect on fragmentation in tandem mass spectrometry of singly charged supramolecular aggregates of sodium sulfonates [PDF]
, 2013 The characteristic collision energy (CCE) to obtain 50% fragmentation of positively and negatively single charged non-covalent clusters has been measured.
Bongiorno, David +7 more
core +2 more sources
Frontiers in Medicine, 2021 Background: Chronic pruritus affects up to 70% of patients with immune-mediated hepatobiliary disorders. Antagonists of the μ-opioid receptor (MOR) and agonists of the κ-opioid receptor (KOR) are used to treat hepatic itch, albeit with limited success ...
Miriam M. Düll +7 more
doaj +1 more source