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Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives [PDF]

open access: yesBiomolecules
Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems.
Mario García-Domínguez
doaj   +3 more sources

The Involvement of Endogenous Enkephalins in Glucose Homeostasis [PDF]

open access: yesBiomedicines, 2023
Obesity has nearly tripled since 1975 and is predicted to continue to escalate. The surge in obesity is expected to increase the risk of diabetes type 2, hypertension, coronary artery disease, and stroke.
Vanessa Escolero   +4 more
doaj   +2 more sources

The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine [PDF]

open access: yesPharmaceuticals
Background: There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system.
Andy Tseng   +3 more
doaj   +2 more sources

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice [PDF]

open access: yeseLife
CD4+CD25+Foxp3+ regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear.
Nicolas Aubert   +14 more
doaj   +2 more sources

Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice [PDF]

open access: yesCommunications Biology, 2023
Opioid-dependent immune-mediated analgesic effects have been broadly reported upon inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local release of enkephalins (endogenous opioids) by colitogenic T lymphocytes alleviate
Xavier Mas-Orea   +18 more
doaj   +2 more sources

Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system [PDF]

open access: yesFrontiers in Pharmacology, 2022
The opioid system plays a crucial role in maintaining gastrointestinal homeostasis. Endogenous opioid peptide enkephalins have anti-inflammatory effect and participate in the treatment of inflammatory bowel diseases (IBDs).
Pan Luo   +6 more
doaj   +2 more sources

Endogenous Opioids in Crohn’s Disease [PDF]

open access: yesBiomedicines, 2023
Caring for patients with Crohn’s disease (CD) is a serious challenge in modern medicine. The increasing incidence of CD among adolescents and the severe course of the disease create the need for new methods of diagnosis and therapy.
Adrian Martyniak   +2 more
doaj   +2 more sources

Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling. [PDF]

open access: yesPLoS Pathogens
By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS).
Alexis Audibert   +12 more
doaj   +2 more sources

Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model [PDF]

open access: yesArchives of Aesthetic Plastic Surgery, 2023
Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing.
Sun Eung Kim   +2 more
doaj   +1 more source

CARDIOPROTECTIVE EFFECT OF ENKEPHALINS UNDER IMMOBILIZATION STRESS [PDF]

open access: yesBiotechnologia Acta, 2022
Objective: The aim of this study was to investigate the cardioprotective effect of dalargin, a synthetic leu-enkephalin. Methods: The induction of myocardial infarction in rats, which were kept on a diet with excess fat and calcium/sodium salts for ...
І. J. Shcheniavskyi
doaj   +1 more source

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