Results 1 to 10 of about 6,650 (212)

Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives [PDF]

Biomolecules
Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems.
Mario García-Domínguez
doaj   +3 more sources

Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice [PDF]

eLife
Enkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity.
Marwa O Mikati, Petra Erdmann-Gilmore, Rose Connors, Sineadh M Conway, Jim Malone, Justin Woods, Robert W Sprung, Reid R Townsend, Ream Al-Hasani   +8 more
doaj   +4 more sources

The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine [PDF]

Pharmaceuticals
Background: There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system.
Andy Tseng, Syed Muzzammil Ahmad, Abdul Hamid, Kabirullah Lutfy   +3 more
doaj   +2 more sources

Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements. [PDF]

CNS Neurosci Ther
The cycle between nicotine use and pain modulation. Cigarette smoking leads to nicotine entering the body, which binds to nicotinic acetylcholine receptors (nAChRs) in the brain, triggering the release of different neurotransmitters, including dopamine (DA), norepinephrine (NE), serotonin (5‐HT), and GABA.
Hu SS, Zhang CF, Lkhagvasuren B, Wang D.
europepmc   +2 more sources

Exposure to exogenous enkephalins disrupts reproductive development in the Eastern lubber grasshopper, Romalea microptera (Insecta: Orthoptera). [PDF]

PLoS ONE, 2012
Enkephalins play a major role in reproductive physiology in crustaceans; however their role in reproductive development in insects is largely unknown. We investigated the effect of exposure to exogenous leucine-enkephalin (Leu-Enk), methionine-enkephalin
Sandeep Kumar, Ganji Purnachandra Nagaraju, Hojun Song, Laurence von Kalm, David W Borst   +4 more
doaj   +4 more sources

The Involvement of Endogenous Enkephalins in Glucose Homeostasis

Biomedicines, 2023
Obesity has nearly tripled since 1975 and is predicted to continue to escalate. The surge in obesity is expected to increase the risk of diabetes type 2, hypertension, coronary artery disease, and stroke.
Vanessa Escolero, Laica Tolentino, Abdul Bari Muhammad, Abdul Hamid, Kabirullah Lutfy   +4 more
doaj   +2 more sources

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice [PDF]

eLife
CD4+CD25+Foxp3+ regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear.
Nicolas Aubert, Madeleine Purcarea, Julien Novarino, Julien Schopp, Alexis Audibert, Wangtianrui Li, Marie Fornier, Léonie Cagnet, Marie Naturel, Armanda Casrouge, Marie-Caroline Dieu-Nosjean, Nicolas Blanchard, Gilles Dietrich, Cedric Peirs, Gilles Marodon   +14 more
doaj   +2 more sources

Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling [PDF]

Communications Biology
Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met ...
Prakashkumar Dobariya, Jessica Williams, Filip Hanak, Patrick E. Rothwell, Swati S. More   +4 more
doaj   +2 more sources

Racecadotril induced bilateral uveal effusion: a case report [PDF]

BMC Ophthalmology
Background Uveal effusion is a sight threatening condition, due to possible acute angle-closure glaucoma and maculopathy. We present a case of bilateral uveal effusion after taking racecadotril, an enkephalinase inhibitor used as a medical treatment for ...
Jona Callaert, Pieter-Paul Schauwvlieghe, Joachim Van Calster   +2 more
doaj   +2 more sources

Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling. [PDF]

PLoS Pathogens
By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS).
Alexis Audibert, Xavier Mas-Orea, Léa Rey, Marcy Belloy, Emilie Bassot, Louise Battut, Gilles Marodon, Frederick Masson, Matteo Serino, Nicolas Cenac, Gilles Dietrich, Chrystelle Bonnart, Nicolas Blanchard   +12 more
doaj   +2 more sources