Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives [PDF]
BiomoleculesEnkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems.
Mario García-Domínguez
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The Involvement of Endogenous Enkephalins in Glucose Homeostasis [PDF]
Biomedicines, 2023 Obesity has nearly tripled since 1975 and is predicted to continue to escalate. The surge in obesity is expected to increase the risk of diabetes type 2, hypertension, coronary artery disease, and stroke.
Vanessa Escolero +4 more
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The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine [PDF]
PharmaceuticalsBackground: There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system.
Andy Tseng +3 more
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Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice [PDF]
eLifeCD4+CD25+Foxp3+ regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear.
Nicolas Aubert +14 more
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Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice [PDF]
Communications Biology, 2023 Opioid-dependent immune-mediated analgesic effects have been broadly reported upon inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local release of enkephalins (endogenous opioids) by colitogenic T lymphocytes alleviate
Xavier Mas-Orea +18 more
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Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system [PDF]
Frontiers in Pharmacology, 2022 The opioid system plays a crucial role in maintaining gastrointestinal homeostasis. Endogenous opioid peptide enkephalins have anti-inflammatory effect and participate in the treatment of inflammatory bowel diseases (IBDs).
Pan Luo +6 more
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Endogenous Opioids in Crohn’s Disease [PDF]
Biomedicines, 2023 Caring for patients with Crohn’s disease (CD) is a serious challenge in modern medicine. The increasing incidence of CD among adolescents and the severe course of the disease create the need for new methods of diagnosis and therapy.
Adrian Martyniak +2 more
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Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling. [PDF]
PLoS PathogensBy eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS).
Alexis Audibert +12 more
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Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model [PDF]
Archives of Aesthetic Plastic Surgery, 2023 Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing.
Sun Eung Kim +2 more
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CARDIOPROTECTIVE EFFECT OF ENKEPHALINS UNDER IMMOBILIZATION STRESS [PDF]
Biotechnologia Acta, 2022 Objective: The aim of this study was to investigate the cardioprotective effect of dalargin, a synthetic leu-enkephalin. Methods: The induction of myocardial infarction in rats, which were kept on a diet with excess fat and calcium/sodium salts for ...
І. J. Shcheniavskyi
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