Results 1 to 10 of about 29,644 (199)

Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives. [PDF]

Biomolecules
Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems.
García-Domínguez M.
europepmc   +4 more sources

The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine. [PDF]

Pharmaceuticals (Basel)
Background: There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system.
Tseng A, Ahmad SM, Hamid A, Lutfy K.
europepmc   +2 more sources

The Involvement of Endogenous Enkephalins in Glucose Homeostasis. [PDF]

Biomedicines, 2023
Obesity has nearly tripled since 1975 and is predicted to continue to escalate. The surge in obesity is expected to increase the risk of diabetes type 2, hypertension, coronary artery disease, and stroke.
Escolero V, Tolentino L, Muhammad AB, Hamid A, Lutfy K.   +4 more
europepmc   +2 more sources

Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience

Neural Plasticity, 2017
Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for ...
M. Henry, L. Gendron, M. Tremblay, G. Drolet   +3 more
semanticscholar   +2 more sources

Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice. [PDF]

Elife
Enkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity.
Mikati MO, Erdmann-Gilmore P, Connors R, Conway SM, Malone J, Woods J, Sprung RW, Townsend RR, Al-Hasani R.   +8 more
europepmc   +2 more sources

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice. [PDF]

Elife
CD4+CD25+Foxp3+ regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear.
Aubert N, Purcarea M, Novarino J, Schopp J, Audibert A, Li W, Fornier M, Cagnet L, Naturel M, Casrouge A, Dieu-Nosjean MC, Blanchard N, Dietrich G, Peirs C, Marodon G.   +14 more
europepmc   +2 more sources

Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice. [PDF]

Commun Biol, 2023
Opioid-dependent immune-mediated analgesic effects have been broadly reported upon inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local release of enkephalins (endogenous opioids) by colitogenic T lymphocytes alleviate
Mas-Orea X, Rey L, Battut L, Bories C, Petitfils C, Abot A, Gheziel N, Wemelle E, Blanpied C, Motta JP, Knauf C, Barreau F, Espinosa E, Aloulou M, Cenac N, Serino M, Mouledous L, Fazilleau N, Dietrich G.   +18 more
europepmc   +2 more sources

Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling. [PDF]

Commun Biol
Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met ...
Dobariya P, Williams J, Hanak F, Rothwell PE, More SS.   +4 more
europepmc   +2 more sources

Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling. [PDF]

PLoS Pathog
By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS).
Audibert A, Mas-Orea X, Rey L, Belloy M, Bassot E, Battut L, Marodon G, Masson F, Serino M, Cenac N, Dietrich G, Bonnart C, Blanchard N.   +12 more
europepmc   +2 more sources

Reduced nucleus accumbens enkephalins underlie vulnerability to social defeat stress

Neuropsychopharmacology, 2019
Ramesh Chandra, T Chase Francis, Joseph F Cheer   +2 more
exaly   +2 more sources