Results 21 to 30 of about 11,957 (196)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

The regulatory role of bile acid microbiota in the progression of liver cirrhosis

Frontiers in Pharmacology, 2023
Bile acids (BAs) are synthesized in liver tissue from cholesterol and are an important endocrine regulator and signaling molecule in the liver and intestine.
Feng Zhu, Shudan Zheng, Mei Zhao, Fan Shi, Lihong Zheng, Haiqiang Wang   +5 more
doaj   +1 more source

Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat

Journal of Lipid Research, 1993
Cholesterol 7 alpha-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts returning to the liver via the portal circulation.
MP Jones, WM Pandak, DM Heuman, JY Chiang, PB Hylemon, ZR Vlahcevic   +5 more
doaj   +1 more source

The hepatobiliary axis and lipoprotein metabolism: effects of bile acid sequestrants and ileal bypass surgery

Journal of Lipid Research, 1982
Cholesterol excretion from the body is achieved almost exclusively via the hepatobiliary axis. Disruption of the integrity of this pathway by interruption of the enterohepatic circulation produces profound changes in cholesterol metabolism that affect ...
C J Packard, J Shepherd
doaj   +1 more source

The economy of the enterohepatic circulation of bile acids in the baboon. 1. Studies of controlled enterohepatic circulation of bile acids.

Journal of Lipid Research, 1984
A primate model with controlled enterohepatic circulation has been developed which allowed short-term evaluation of bile salt pool size, cycling frequency, and fecal losses.
R N Redinger, J W Hawkins, D M Grace
doaj   +1 more source

Enterohepatic circulation in hamsters with an extracorporeal bile duct.

Journal of Lipid Research, 1992
The present study describes a novel technique for investigations of the enterohepatic circulation in the hamster with an extracorporeal bile duct that allows long-term bile collection in the free-moving animal.
M Fuchs, J Scheibner, E Hörmann, G Tauber, EF Stange   +4 more
doaj   +1 more source

Identification and Spatial Visualization of Dysregulated Bile Acid Metabolism in High-Fat Diet-Fed Mice by Mass Spectral Imaging

Frontiers in Nutrition, 2022
Changes in overall bile acid (BA) levels and specific BA metabolites are involved in metabolic diseases, gastrointestinal, and liver cancer. BAs have become established as important signaling molecules that enable fine-tuned inter-tissue communication ...
Qi Zhang, Qi Zhang, Zhen-Hua Wu, Zhen-Hua Wu, Zhen-Hua Wu, Shan-Shan Zhao, Shan-Shan Zhao, Shan-Shan Zhao, Jing Yang, Jing Yang, Jing Yang, Lei Chen, Lei Chen, Lei Chen, Xiao-Yu Wang, Xiao-Yu Wang, Xiao-Yu Wang, Zhan-You Wang, Hui-Xin Liu, Hui-Xin Liu, Hui-Xin Liu   +20 more
doaj   +1 more source

Biliary excretion and enterohepatic circulation of thienorphine and its glucuronide conjugate in rats

Acta Pharmaceutica Sinica B, 2012
Thienorphine (TNP) is a new partial opioid agonist currently developed as a promising drug candidate with the intended clinical indication for the treatment of opioid dependence.
Jingting Deng, Xiaomei Zhuang, Guolin Shen, Hua Li, Zehui Gong   +4 more
doaj   +1 more source

A computer study of the risk of cholesterol gallstone associated with obesity and normal weight

Scientific Reports, 2021
Obese people differ from the people of normal weight in gall bladder motility and have a higher risk of cholesterol stone formation. In this study, using a mathematical model of cholesterol homeostasis, which also considers the enterohepatic circulation ...
Krystian Kubica, Joanna Balbus
doaj   +1 more source

Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

Acta Pharmaceutica Sinica B, 2015
The classical functions of bile acids include acting as detergents to facilitate the digestion and absorption of nutrients in the gut. In addition, bile acids also act as signaling molecules to regulate glucose homeostasis, lipid metabolism and energy ...
Courtney B. Ferrebee, Paul A. Dawson
doaj   +1 more source