Results 41 to 50 of about 11,957 (196)
The gut microbiome: an orchestrator of xenobiotic metabolism
Acta Pharmaceutica Sinica B, 2020 Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism. The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter the metabolic outcome of pharmaceuticals, environmental toxicants,
Stephanie L. Collins +1 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra +4 more
wiley +1 more source
Food Bioengineering, EarlyView.Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi +4 more
wiley +1 more source
Does Adriamycin Undergo an Enterohepatic Circulation?
Experimental Biology and Medicine, 1982 AbstractTo determine whether adriamycin (ADR) and/or its metabolites undergo an enterohepatic circulation following an iv administration, anesthetized rats with biliary and urinary fistulae were intraduodenally perfused with bile flowing from bile duct-cannulated rats which had been injected iv with 20 mg/kg [14C]ADR.
N, Tavoloni, A M, Guarino
openaire +2 more sources
Buck Wheat: Nutritional, Bioactive Characteristics, Health Benefits, and Side Effects
Future Postharvest and Food, EarlyView.ABSTRACT Micronutrient deficits have resulted from an over‐reliance on a small number of cereal crops for food security. The agricultural sector faces severe sustainability issues due to the rapid growth of the world's population and sudden climatic changes.
Momina Farooq +2 more
wiley +1 more source
Canadian Journal of Gastroenterology, 2007 BACKGROUND: Cholesterol, in the form of bile salts, is reabsorbed from the small intestine via the enterohepatic circulation. Biliary sphincterotomy increases the delivery of bile to the terminal ileum. If the absorptive capacity is exceeded, cholesterol
Waleed M Alazmi +5 more
doaj +1 more source
PHYSIOLOGY OF CHOLESTEROL METABOLISM (THE REVIEW)
Acta Biomedica Scientifica, 2012 There are two sources of cholesterol: endogenous (biliary) and exogenous (dietary) in human organism. Biliary cholesterol arrives with cyctic and. hepatic bile in small intestine and. is mixed, with dietary cholesterol.
YA. L. Tyuryumin +2 more
doaj
Egyptian Liver JournalGallstone disease is a widespread health issue driven by genetic, metabolic, and environmental factors. Among its types, pigment stones, primarily composed of bilirubin, arise due to disruptions in bilirubin metabolism.
Jashwanth Balu +7 more
doaj +1 more source
Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)[S]
Journal of Lipid Research, 2012 The apical Na+-dependent bile salt transporter (ASBT/SLC10A2) is essential for maintaining the enterohepatic circulation of bile salts. It is not known when Slc10a2 evolved as a bile salt transporter or how it adapted to substantial changes in bile salt ...
Daniël A. Lionarons +2 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Disturbances of the enterohepatic circulation of bile acids (BAs) are seen in a number of clinically important conditions, including metabolic disorders, hepatic impairment, diarrhea, and gallstone disease.
Veronika Voronova +8 more
doaj +1 more source