Results 51 to 60 of about 11,957 (196)

The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle

Metabolites, 2023
Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock.
Di Wu, Song Wang, Chao Hai, Linfeng Wang, Dongchao Pei, Chunling Bai, Guanghua Su, Xuefei Liu, Yuefang Zhao, Zhonghua Liu, Lei Yang, Guangpeng Li   +11 more
doaj   +1 more source

Oat β‐Glucan and Galactooligosaccharides Influence Gallstone Formation by Modulating the Gut Microbiota, Particularly Desulfovibrionales

iMetaMed, EarlyView.
Oat β‐glucan and galactooligosaccharides influence the formation of gallstones by modulating the gut microbiota, particularly the abundance of Desulfovibrionales. The primary mechanism involves metabolic byproducts associated with Desulfovibrionales inhibiting hepatic bile acid synthesis via both the hepatic FXR–SHP and intestinal FXR–FGF15 signaling ...
Liang Tian, Yanyan Lin, Ping Yue, Long Gao, Leiqing Wang, Chongfei Huang, Jinyu Zhao, Ningzu Jiang, Jiahui xi, Haidong Ma, Zhen Liu, Ruyang Zhong, Wenkang Fu, Ningning Mi, Mingzhen Bai, Bodong Zhang, Lunzhi Dai, Jiang Li, Hu Chen, Jinqiu Yuan, Wenbo Meng   +20 more
wiley   +1 more source

Incidence and Determinants of Steatotic Liver Disease after Pancreaticoduodenectomy: A Systematic Review and Meta‐Analysis

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Steatotic liver disease (SLD) is an unrecognized complication after pancreaticoduodenectomy (PD) and may affect nutrition and long‐term recovery. This meta‐analysis estimated the incidence of SLD after PD and identified its clinical and surgical risk factors.
Ronnakorn Kongsakon, Wasit Wongtrakul, Khemajira Karaketklang, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya   +4 more
wiley   +1 more source

Cholecystectomy Is Linked With Lower Respiratory Exchange Ratio and Higher Lipid Oxidation and Sleep Energy Expenditure

Obesity, EarlyView.
ABSTRACT Objective Cholecystectomy (GBX) may alter energy metabolism, but human evidence is limited. We examined whether GBX alters energy expenditure (EE), respiratory exchange ratio (RER), and substrate oxidation. Methods A total of 384 healthy Southwestern Indigenous American adults (222 males, age 28 ± 6 years) were studied, including individuals ...
Beyza N. Aydin, Emma J. Stinson, Helen C. Looker, Peter Walter, Tomás Cabeza de Baca, Jonathan Krakoff, Douglas C. Chang   +6 more
wiley   +1 more source

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn’s Disease

Canadian Journal of Gastroenterology and Hepatology, 2022
Background. Bile acids help maintain the physiological balance of the gut microbiome and the integrity of the intestinal epithelial barrier. Similarly, intestinal bacteria play a major role in bile acid metabolism as they are involved in crucial ...
Aditi Kumar, Hafid O. Al-Hassi, Helen Steed, Oliver Phipps, Matthew J. Brookes   +4 more
doaj   +1 more source

Relationship Between Fecal Bile Acid Profile and Intestinal Microbiota in Patients With Chronic Radiation Enteritis

Journal of Digestive Diseases, EarlyView.
Patients with chronic radiation enteritis (CRE) demonstrate dysregulated bile acid (BA) metabolism, characterized by an increased proportion of primary BAs and a decreased proportion of secondary BAs. Moreover, the diversity of the intestinal microbiota is significantly reduced in individuals with CRE, and there is a bidirectional interaction between ...
Xin Shen, Song Bo Li, Meng Jie Gao, Jiao Jiao Cao, Hua Yang, Wei Wei Li, Li Chun Wei, Min Chen, Jun Ye Liu, Yong Quan Shi   +9 more
wiley   +1 more source

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, EarlyView.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

Cell Reports, 2014
Gut microbiota influences host health status by providing trophic, protective, and metabolic functions, including bile acid (BA) biotransformation.
Chiara Degirolamo, Stefania Rainaldi, Fabiola Bovenga, Stefania Murzilli, Antonio Moschetta   +4 more
doaj   +1 more source