Results 71 to 80 of about 11,957 (196)

Analysis of gut microecological characteristics and differences between children with biliary atresia and non-biliary atresia in infantile cholestasis

Frontiers in Cellular and Infection Microbiology
IntroductionIn infants with cholestasis, variations in the enterohepatic circulation of bile acids and the gut microbiota (GM) characteristics differ between those with biliary atresia (BA) and non-BA, prompting a differential analysis of their ...
Yajun Liu, Yuan Zhang, Cheng Guo, Muxia Li, Ye Wang, Lin Zhang   +5 more
doaj   +1 more source

Prolonged Intrahepatic Cholestasis After Acute Hepatitis E Infection: A Case Series and Genetic Analysis

Journal of Viral Hepatitis, Volume 33, Issue 4, April 2026.
ABSTRACT Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide. Whereas HEV infection is typically self‐limiting, rare cases of prolonged cholestasis have been reported. The underlying mechanisms remain unclear, though host genetic variation may contribute.
Montserrat Fraga, Sophie Kasmi, Susanne N. Weber, Roman Liebe, Christine Sempoux, Ali Saadat, Jacques Fellay, Silke Kenngott‐Kelber, Vincent Zimmer, Frank Lammert, Marcin Krawczyk, Christoph Jüngst   +11 more
wiley   +1 more source

Dysbiosis in the Gut‐Liver Axis Is Associated With Low Bone Mass During Murine Cholestasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Dysbiosis in the gut‐liver axis drives a dysregulation in bile acid metabolism that increases bile acid efflux into systemic circulation and the bone marrow. Bile acid signaling in the marrow promotes osteoclastogenesis and suppresses osteoblastogenesis, which drives bone loss during cholestatic liver disease in mice. ABSTRACT The gut‐liver axis is the
Brooke Hutchison, Jamie Fornsaglio, Ridgeway Case IV, Pam Cornuet, Fu‐Ying Qin, Xiaochao Ma, Kari Nejak‐Bowen, Matthew D. Carson   +7 more
wiley   +1 more source

Bile acid transporters

Journal of Lipid Research, 2009
In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and ...
Paul A. Dawson, Tian Lan, Anuradha Rao
doaj   +1 more source

Gut Microbiome Dysbiosis Promotes Gallstone Formation via Bile Acid Metabolic Disorder: A Multiomics Study

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Gallstone patients exhibit intestinal dysbiosis, which leads to bile acid dysregulation. Gallstone patients exhibited increased levels of bacteria with bile salt hydrolase (BSH) activity. In gallstone patients, the levels of hydrophobic bile acids (e.g., lithocholic acid) were increased, while the levels of hydrophilic bile acids (e.g ...
Chongfei Huang, Weijun Xiao, Jinyu Zhao, Ruyang Zhong, Long Gao, Haidong Ma, Liang Tian, Ping Yue, Yanyan Lin, Qiangsheng He, Bin Xia, Jinqiu Yuan, Man Yang, Wenbo Meng   +13 more
wiley   +1 more source

Quantifying Forms and Functions of Enterohepatic Bile Acid Pools in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology
Backgrounds & Aims: Bile acids (BAs) are core gastrointestinal metabolites with dual functions in lipid absorption and cell signaling. BAs circulate between the liver and distal small intestine (i.e., ileum), yet the dynamics through which complex BA
Koichi Sudo, Amber Delmas-Eliason, Shannon Soucy, Kaitlyn E. Barrack, Jiabao Liu, Akshaya Balasubramanian, Chengyi Jenny Shu, Michael J. James, Courtney L. Hegner, Henry D. Dionne, Alex Rodriguez-Palacios, Henry M. Krause, George A. O’Toole, Saul J. Karpen, Paul A. Dawson, Daniel Schultz, Mark S. Sundrud   +16 more
doaj   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

The Protective Effects of Membrane‐Separated Ripe Pu‐Erh Tea Extracts Against Chronic Alcoholic Liver Injury

Food Frontiers, Volume 7, Issue 2, March 2026.
In this study, we investigated the protective effects of different membrane‐separated ripe Pu‐erh tea on alcohol‐induced liver injury. The result indicated that ripe Pu‐erh tea separated by a 50 nm ceramic membrane (molecular weight < 300 kDa) has the best effect on preventing ALD.
Sibo Zhao, Jielin Jiang, Yan Liu, Mianhong Xu, Rui Yang, Zhi Yang, Jilin Xie, Zhanggui Ding, Liyong Luo, Liang Zeng   +9 more
wiley   +1 more source

Alginate Oligosaccharides Attenuate Ochratoxin A‐Induced Liver Injury through Regulating the Interaction of Nrf2 and NF‐κB Signaling Pathways

Food Frontiers, Volume 7, Issue 2, March 2026.
A schematic illustration for the protective effects of AOS on OTA‐induced liver injury in mice. AOS, alginate oligosaccharides; CAT, catalase; GSTT1, glutathione S‐transferase theta 1; HO‐1, heme oxygenase 1; IκBα, inhibitor kappa B alpha; IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; Keap1, kelch‐like ech‐associated protein 1; NF‐κB, nuclear factor ...
Yue Zhao, Xueqing Ye, Yan Guo, Zhongxiang Zhao, Qinghua Yao, Yaoyao Wang, Huimei Liu, Ziwei Lin, Wenchao Liu   +8 more
wiley   +1 more source

enterohepatic circulation

Citation: 'enterohepatic circulation' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15665 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for
openaire   +1 more source