Results 81 to 90 of about 11,957 (196)

FXR‐Mediated Atherosclerosis Alleviation by B. animalis F1‐7 Through Bile Acid Metabolism‐Driven Gut–Liver Axis Modulation

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT This study investigates the mechanisms of B. animalis F1‐7 improving atherosclerosis (AS) through bile acid metabolism by using an “antibiotic cocktail” approach in AS model mice. It was found that B. animalis F1‐7 could effectively reduce lipid accumulation in the aorta of mice, alleviate inflammatory responses and improve the intestinal ...
Tianhu Shan, Jiawen Wang, Yanyang Liu, Huaqi Zhang, Zhe Zhang, Lanwei Zhang, Hui Liang, Xi Liang   +7 more
wiley   +1 more source

Multi‐Target Mechanisms of Whey Protein Against NAFLD: Integrating Bile Acid Metabolism, Gut Microbiota and Hepatic Inflammation

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Whey protein (WP) alleviates high‐fat diet (HFD)‐induced nonalcoholic fatty liver disease (NAFLD) through a tripartite mechanism targeting the gut‐liver axis. (1) Gut Microbiota Modulation: WP restores intestinal flora homeostasis by enriching beneficial taxa (e.g., Lactobacillus) and increasing the production of short‐chain fatty acids (SCFAs).
Dongjin Xu, Biru Qiu, Xueyun Dong, Jiajun Tan, Yunhan Xie, Yuanyuan Wan, Chenghai Chu, Chunrun Miao, Asmaa Ali, Min Chen, Jiayuan He, Liang Wu, Jiayong Xie   +12 more
wiley   +1 more source

Arachis hypogaea L. Root Extract Mitigates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in ICR Mice by Suppressing Inflammation, Androgen Receptors, and Dihydrotestosterone

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
In summary this study evaluated the protective effects of Arachis hypogaea L. root extract (AHRE) against testosterone propionate (TP)‐induced benign prostatic hyperplasia (BPH) in ICR mice. AHRE was prepared and administered in varying doses (100, 200, 300 mg/kg BW) alongside TP, with finasteride as a positive control.
Samee‐Ullah, Faryal Shaukat, Muhammad Umair Ijaz, Muhammad Bilal, Anees Ahmed Khalil, Tausif Ahmad, Yemin Guo, Xia Sun, Yuanda Song, Mohammed Mansour Quradha   +9 more
wiley   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source

Combined Oral Contraceptive Drug–Drug Interaction Study With Ganfeborole, a New Anti‐Tuberculosis Agent

The Journal of Clinical Pharmacology, Volume 66, Issue 3, March 2026.
Abstract New drugs are urgently needed to treat drug‐resistant tuberculosis in combination regimens. Ganfeborole demonstrated bactericidal activity and good tolerability in clinical trials. In preclinical studies, ganfeborole showed embryofetal developmental effects, currently mandating highly effective non‐user dependent contraception in women of ...
Laura Iavarone, Silvia M. Lavezzi, Antonio J. Carcas, Tetyana Chaychenko, Raquel Gabarro‐Carrion, Arturo Gómez López de las Huertas, Stephanie Gresham, Alicia Marín‐Candón, Sophie L. Penman, Katie Rolfe, Simon Tiberi, David Barros‐Aguirre, Alberto M. Borobia, the ERA4TB consortium   +13 more
wiley   +1 more source

Enterohepatic Circulation Model for Population Pharmacokinetic Analysis

Journal of Pharmacy and Pharmacology, 1999
Abstract An enterohepatic circulation model based on physiological aspects of biliary excretion has been developed for population pharmacokinetic analysis. Mycophenolate mofetil was selected as a model drug for validation of the model. As a secondary objective, the model was used for pharmacokinetic comparison among different races.
openaire   +2 more sources

Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity

Molecular Nutrition &Food Research, Volume 70, Issue 5, 12 March 2026.
Compared to pre‐intervention, consuming a tomato‐soy juice (54 mg lycopene, 189 mg soy isoflavones/d) reduced levels of inflammatory cytokines (IL‐5, IL‐12p70, and GM‐CSF, with TNF‐alpha trending downward), increased plasma lycopene and urinary soy isoflavone metabolites, and altered the urinary metabolome. ABSTRACT Chronic, low‐grade inflammation is a
Maria J. Sholola, Jenna Miller, Emma A. Bilbrey, Janet A. Novotny, David M. Francis, Thomas A. Mace, Jessica L. Cooperstone   +6 more
wiley   +1 more source

Disruption of Enterohepatic Circulation of Bile Acids Ameliorates Small Bowel Resection Associated Hepatic Injury. [PDF]

J Pediatr Surg, 2023
Tecos ME, Steinberger AE, Guo J, Rubin DC, Davidson NO, Warner BW.   +5 more
europepmc   +1 more source

Risk Assessment for Drug‐Induced Hyperbilirubinemia: A Mechanistic Approach

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Hyperbilirubinemia, characterized by elevated total blood bilirubin levels including both unconjugated and conjugated forms, serves as a diagnostic marker for drug‐induced liver toxicity associated with a wide range of medications. This study aimed to develop a mechanistic model for assessing hyperbilirubinemia risk using genetic markers.
Rajeev Kumar, Ansu Kumar, Aftab Alam, Yatin Mundkur, James Wingrove   +4 more
wiley   +1 more source

Chronic Gastric Ulceration Due to Cytomegalovirus in Immunocompetent Adults – A Case Report and Systematic Review

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT This case report and systematic review describe the complete clinical course of chronic gastric ulceration complicating acute gastrointestinal CMV disease in a 72‐year‐old immunocompetent woman, with demonstrable response to ganciclovir but not valganciclovir.
Zayn Al‐Timimi, Ashleigh Geddes, Richard Lawrence   +2 more
wiley   +1 more source