Results 31 to 40 of about 2,925 (189)
Intestinal organoid/enteroid-based models for Cryptosporidium
Current Opinion in Microbiology, 2020 Cryptosporidium is a leading cause of diarrhea and death in young children and untreated AIDS patients in resource-poor settings, and of waterborne outbreaks of disease in developed countries. However, there is no consistently effective treatment for vulnerable populations.
Bhalchandra, Seema +2 more
openaire +2 more sources
Microfluidic Device to Manipulate 3D Human Epithelial Cell-Derived Intestinal Organoids
Micromachines, 2022 In this study, we propose a microfluidic organoid-trapping device used to immobilize human intestinal organoids and apply fluidic stimuli to them. The proposed device has a microchannel with a trapping region with wall gaps between the channel walls and ...
Miki Matsumoto +3 more
doaj +1 more source
Frontiers in Microbiology, 2023 Salmonella enterica serovar Typhimurium (STm) is a major foodborne pathogen and poultry are a key reservoir of human infections. To understand the host responses to early stages of Salmonella infection in poultry, we infected 2D and 3D enteroids, the ...
Kate Sutton +7 more
doaj +1 more source
Dasabuvir inhibits human norovirus infection in human intestinal enteroids [PDF]
mSphere, 2021 AbstractHuman noroviruses (HuNoVs) are acute viral gastroenteritis pathogens that affect all age groups, yet no approved vaccines and drugs to treat HuNoV infection are available. In this study, with a human intestinal enteroid (HIE) culture system where HuNoVs are able to replicate reproducibly, we screened an antiviral compound library to identify ...
Tsuyoshi Hayashi +8 more
openaire +3 more sources
From 3D Organoids back to 2D Enteroids [PDF]
Developmental Cell, 2018 In this issue of Developmental Cell, Thorne et al. (2018) describe a simple, scalable method to culture 2D enteroid monolayers that surprisingly recapitulates many of the features of 3D organoid cultures and in vivo intestinal tissue and can be used for high-throughput microscopy-based experiments.
Jonathan, Braverman, Ömer H, Yilmaz
openaire +2 more sources
Corrigendum: Organoid and Enteroid Modeling of Salmonella Infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 [This corrects the article DOI: 10.3389/fcimb.2018.00102.].
Yuebang Yin, Daoguo Zhou, Daoguo Zhou
doaj +3 more sources
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]
, 2013 Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D +6 more
core +2 more sources
mBio, 2018 Enteroaggregative Escherichia coli (EAEC) is an important diarrheal pathogen and a cause of both acute and chronic diarrhea. It is a common cause of pediatric bacterial diarrhea in developing countries.
Anubama Rajan +11 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Cell line authentication is critical for preventing the use of mixed or misidentified cell lines in research. Current efforts include short tandem repeat (STR) analysis and PCR-based assays to detect mixed species cultures.
Margaret S. Bohm +12 more
doaj +1 more source
A Multicellular In Vitro Model of the Human Intestine with Immunocompetent Features Highlights Host-Pathogen Interactions During Early Salmonella Typhimurium Infection. [PDF]
Adv Sci (Weinh)In this work, a human primary cell‐based immunocompetent model is established to investigate early responses to STm infection. Intestinal fibroblasts and monocyte‐derived macrophages are embedded in decellularized small intestinal submucosa (SIS) from domestic pigs, followed by the development of an enteroid monolayer.
Damigos S +10 more
europepmc +2 more sources