Results 11 to 20 of about 1,444 (144)

An enteropathogenic microbial toxin modulates the breast cancer epigenome resulting in concurrent silencing of tumor suppressor genes [PDF]

Breast Cancer Research
Background Recent studies have determined a close association between host microbiota and breast cancer initiation, growth and therapeutic outcomes.
Deepak Verma, Deeptashree Nandi, Sheetal Parida, Archisha Saxena, Dipali Sharma   +4 more
doaj   +2 more sources

Anaerobic gut bacteria and their potential role in the initiation, exacerbation, and development of human colorectal cancer: a narrative review [PDF]

Frontiers in Cellular and Infection Microbiology
Colorectal cancer (CRC) is known as the second leading cause of cancer-related deaths around the world. Rectal bleeding, changes in bowel movements, weight loss, and fatigue are the main clinical presentations of CRC.
Sahar Sabour, Sahar Sabour, Hanieh Sadeghi Koupaei, Hadi Ghasemi, Mansour Amin, Mansour Amin, Taher Azimi   +6 more
doaj   +2 more sources

Gut microbiota and colorectal cancer: mechanistic insights, diagnostic advances, and microbiome-based therapeutic strategies [PDF]

Frontiers in Microbiology
Colorectal cancer (CRC) is closely linked to gut microbiota dysbiosis. We synthesize evidence that carcinogenic microbes promote CRC through chronic inflammation, bacterial genotoxins, and metabolic imbalance, highlighting key pathways involving ...
Bingbing Bai, Bingbing Bai, Bingbing Bai, Bingbing Bai, Jianing Ma, Jianing Ma, Jianing Ma, Jianing Ma, Wenlong Xu, Wenlong Xu, Wenlong Xu, Wenlong Xu, Xiaomin Chen, Xiaomin Chen, Xiaomin Chen, Xiaomin Chen, Xu Chen, Xu Chen, Xu Chen, Xu Chen, Chao Lv, Chao Lv, Chao Lv, Chao Lv, Wei Su, Wei Su, Wei Su, Wei Su, Yaoxu Li, Yaoxu Li, Yaoxu Li, Yaoxu Li, Hongyin Sun, Hongyin Sun, Hongyin Sun, Hongyin Sun, Baoyin Zhang, Baoyin Zhang, Baoyin Zhang, Baoyin Zhang, Dejuan Xiang, Dejuan Xiang, Dejuan Xiang, Dejuan Xiang, Zhongsha Li, Zhongsha Li, Zhongsha Li, Zhongsha Li, Yuesong Wu, Yuesong Wu, Yuesong Wu, Yuesong Wu, Jian Sun, Jian Sun, Jian Sun, Jian Sun, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin   +59 more
doaj   +2 more sources

Outer Membrane Vesicles From <i>Bacteroides fragilis</i> Contain Coding and Non-Coding Small RNA Species That Modulate Inflammatory Signalling in Intestinal Epithelial Cells. [PDF]

J Extracell Biol
Outer membrane vesicles (OMVs) from Bacteroides fragilis carry distinct coding and non‐coding RNAs that influence host inflammatory signaling. Extravesicular RNAs from OMVs suppress IL‐8 expression in intestinal epithelial cells, while removal of these RNAs enhances pro‐inflammatory IL‐8 responses.
Sheikh A, Scano C, Xu J, Ojo T, Conforti JM, Haberman KL, King B, Martinez AS, Pujol M, Watkins J, Lotter J, Lin EL, Zechmann B, Sevcik A, Sayes C, Gallagher ES, Lang SP, Mell J, Ehrlich GD, Taube JH, Greathouse KL.   +20 more
europepmc   +2 more sources

The tumor-microbe connection. [PDF]

Mol Oncol
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Vella G, Rescigno M.
europepmc   +2 more sources

Repositioning small molecule drugs as allosteric inhibitors of the BFT-3 toxin from enterotoxigenic Bacteroides fragilis [PDF]

, 2022
Bacteroides fragilis is an abundant commensal component of the healthy human colon. However, under dysbiotic conditions, enterotoxigenic B. fragilis (ETBF) may arise and elicit diarrhea, anaerobic bacteremia, inflammatory bowel disease, and colorectal ...
Abian, Olga, Asencio del Rio, Marta, Eckhard, Ulrich, Gomis-Rüth, Francesc Xavier, Guevara, Tibisay, Jimenez-Alesanco, Ana, Vega, Sonia, Velazquez-Campoy, Adrian   +7 more
core   +1 more source

Enterotoxigenic Bacteroides fragilis: A Possible Etiological Candidate for Bacterially-Induced Colorectal Precancerous and Cancerous Lesions

Frontiers in Cellular and Infection Microbiology, 2020
Enterotoxigenic Bacteroides fragilis (ETBF) produces Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and colorectal cancer (CRC).
Samin Zamani, Samin Zamani, Reza Taslimi, Akram Sarabi, Seyedesomaye Jasemi, Leonardo A. Sechi, Mohammad Mehdi Feizabadi, Mohammad Mehdi Feizabadi   +7 more
doaj   +1 more source

Structure of the gut microbiome following colonization with human feces determines colonic tumor burden [PDF]

, 2014
Background A growing body of evidence indicates that the gut microbiome plays a role in the development of colorectal cancer (CRC). Patients with CRC harbor gut microbiomes that are structurally distinct from those of healthy individuals;
Baxter, Nielson T, Chen, Grace Y, Schloss, Patrick D, Zackular, Joseph P   +3 more
core   +3 more sources

Enterotoxigenic Bacteroides fragilis activates IL-8 expression through Stat3 in colorectal cancer cells

Gut Pathogens, 2022
Background Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in colorectal carcinogenesis through the actions of its toxin, B. fragilis toxin (BFT).
Rachel V. Purcell, Jessica Permain, Jacqueline I. Keenan   +2 more
doaj   +1 more source

Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island. [PDF]

PLoS ONE, 2014
Bacteroides fragilis causes the majority of Gram-negative anaerobic infections in the humans. The presence of a short, 6-kb, pathogenicity island in the genome is linked to enterotoxigenic B. fragilis (ETBF). The role of the enterotoxin in B.
Albert G Remacle, Sergey A Shiryaev, Alex Y Strongin   +2 more
doaj   +1 more source