Results 11 to 20 of about 23,392 (228)

Regulatory effects of eotaxin, eotaxin-2, and eotaxin-3 on eosinophil degranulation and superoxide anion generation.

Experimental biology and medicine (Maywood, N.J.), 2002
Eosinophilic leukocytes have been implicated as primary effector cells in inflammatory and allergic diseases. When activated by cytokines, human eosinophils secrete and produce a variety of proinflammatory or tissue damaging substances. Although well known for their chemoattractant effects, little is known about the precise contribution of the ...
A P, Badewa, C E, Hudson, A S, Heiman
openaire   +3 more sources

Rhinovirus infection up‐regulates eotaxin and eotaxin‐2 expression in bronchial epithelial cells

Clinical & Experimental Allergy, 2001
Background Human rhinoviruses (RVs) are the most common precipitants of asthma exacerbations. RV infection of bronchial epithelium results in local airway inflammation inducing eosinophil recruitment and activation. Induction of eosinophil chemoattractants could represent a central mechanism, as well as a prime target for intervention.Objective To ...
PAPADOPOULOS NG, PAPI, Alberto, MEYER J, STANCIU LA, SALVI S, HOLGATE ST, JOHNSTON SL   +6 more
core   +7 more sources

Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis

Ophthalmology, 2003
Eotaxin-1 and eotaxin-2 are potent eosinophil chemotactic and activating peptides that may be implicated in the pathogenesis of the chronic allergic eye diseases vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC). The purpose of this study was to measure these chemokines in tear and mucus samples of active-disease patients and in ...
Andrea, Leonardi, Peter J, Jose, Hong, Zhan, Virginia L, Calder   +3 more
core   +5 more sources

Elevated Levels of Eotaxin-2 in Serum of Fibromyalgia Patients

Pain Research and Management, 2018
FMS patients demonstrate an altered profile of chemokines relative to healthy controls (HC). Eotaxin-2 is a potent chemoattractant distributed in a variety of tissues. The aim of the study was to compare serum levels of eotaxin-2 between FMS patients and
Victoria Furer, Eyal Hazan, Adi Mor, Michal Segal, Avi Katav, Valerie Aloush, Ori Elkayam, Jacob George, Jacob N. Ablin   +8 more
doaj   +2 more sources

Proton pump inhibitors decrease eotaxin-3 expression in the proximal esophagus of children with esophageal eosinophilia.

PLoS ONE, 2014
ObjectiveBesides reducing gastric acid secretion, proton pump inhibitors (PPIs) suppress Th2-cytokine-stimulated expression of an eosinophil chemoattractant (eotaxin-3) by esophageal epithelial cells through acid-independent, anti-inflammatory mechanisms.
Jason Y Park, Xi Zhang, Nathalie Nguyen, Rhonda F Souza, Stuart J Spechler, Edaire Cheng   +5 more
doaj   +2 more sources

Distinct Roles Between Eotaxin 1 and Eotaxin 2 in Asthmatic Airways

Clinical and Translational Allergy
Background Eotaxins (EOTs), primarily expressed in airway epithelial cells (AECs), act as chemoattractants for eosinophils in asthma pathogenesis. Recent studies have suggested that EOTs have additional functions beyond chemotaxis.
Soyoon Sim, Eun‐mi Yang, Yoo Seob Shin, Seon Beom Kim, Youngwoo Choi, Hae‐Sim Park   +5 more
doaj   +3 more sources

Revisiting the Role of Eotaxin-1/CCL11 in Psychiatric Disorders [PDF]

Frontiers in Psychiatry, 2018
Eotaxin-1/CCL11 is a chemokine originally implicated in the selective recruitment of eosinophils into inflammatory sites during allergic reactions, being thoroughly investigated in asthma, allergic rhinitis, and other eosinophil-related conditions ...
Antonio L. Teixeira, Antonio L. Teixeira, Clarissa S. Gama, Natalia P. Rocha, Natalia P. Rocha, Mauro M. Teixeira   +5 more
doaj   +4 more sources

The role of the eosinophil-selective chemokine, eotaxin, in allergic and non-allergic airways inflammation

Memorias do Instituto Oswaldo Cruz, 1997
Blood eosinophilia and tissue infiltration by eosinophils are frequently observed in allergic inflammation and parasitic infections. This selective accumulation of eosinophils suggested the existence of endogenous eosinophil-selective chemoattractants ...
Dolores M Conroy, Alison A Humbles, Sara M Rankin, Roger T Palframan, Paul D Collins, David A Griffiths-Johnson, Peter J Jose, Timothy J Williams   +7 more
doaj   +2 more sources

Eotaxin and Obesity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2006
Asthma and obesity incidence is increasing worldwide, and asthma is often more severe in the obese. Eotaxin, a CC chemokine, is important in extrinsic asthma, an inflammatory disorder.Our objective was to examine the relation between eotaxin and obesity.We conducted a comparison study of eotaxin in mice fed high-fat vs. standard chow diet for 26 wk, in
Abu R, Vasudevan, Huaizhu, Wu, Antonios M, Xydakis, Peter H, Jones, E O'Brian, Smith, John F, Sweeney, David B, Corry, Christie M, Ballantyne   +7 more
openaire   +2 more sources

Difference of Serum Cytokine Profile in Allergic Asthma Patients According to Disease Severity

Journal of Asthma and Allergy, 2022
Lin Sun,1– 3,* Bo Peng,1– 3,* Jun Zhou,1– 3 Ping Wang,1 Yuqing Mo,4 Guofang Xu,1 Yi Tao,1 Hejie Song,1– 3 Wei Tang,1– 3 Meiling Jin4 1Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of ...
Sun L, Peng B, Zhou J, Wang P, Mo Y, Xu G, Tao Y, Song H, Tang W, Jin M   +9 more
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