Results 41 to 50 of about 23,392 (228)

Description of an in vivo model for the assessment of eosinophil chemoattractants in the mouse

Memorias do Instituto Oswaldo Cruz, 1997
Chemokines (chemoattractant cytokines) induce potent and selective chemotaxis of leukocyte subsets in vitro. Here, we review briefly the chemokines shown to induce eosinophil chemotaxis in vitro and describe a novel model for the study of the ability of ...
Mauro M Teixeira, Timothy J Williams, Paul G Hellewell   +2 more
doaj   +1 more source

Eotaxin-2/CCL24 and eotaxin-3/CCL26 exert differential profibrogenic effects on human lung fibroblasts

, 2010
BACKGROUND: Eotaxin-2/CCL24 and eotaxin-3/CCL26 play an important role in eosinophil chemotaxis and activation in asthma. We previously demonstrated that eotaxin/CCL11 is profibrogenic for human lung fibroblasts.
Reich R, Levi Schaffer F, PUXEDDU, ILARIA, Kohan M, Berkman N.   +4 more
core   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Eotaxin-induced expression of membrane type 1 matrix metalloproteinase mRNA in human eosinophils

Allergology International, 2000
Eosinophil penetration across the basement membrane (BM) is thought to be dependent on the degradation of membrane components. In this process, matrix metalloproteinases (MMP) appear to be primarily responsible for degradation of the BM.
Izumi Kurosaki, Taku Satoh, Koji Murakami, Takeshi Tastumi, Noriyasu Mitani, Ikuo Saiki   +5 more
doaj   +1 more source

Eotaxin and eotaxin receptor (CCR3) expression in Sephadex particle- induced rat lung inflammation

, 1999
The β chemokine eotaxin is a potent eosinophil activator and chemoattractant. We examined immunohistochemically eotaxin protein expression in a range of normal rat tissues and in rat during Sephadex particle-induced pulmonary inflammation.
Flanagan, B. F., Dearman, R. J., Newton, D. J., Kimber, I., Hunt, J. A., Willlams, C. M M, Coleman, J. W., Harrington, P. M.   +7 more
core   +1 more source

Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park   +5 more
wiley   +1 more source

The Role of Saturated Fatty Acids in Connexin Expression on Endothelial Cells and Eosinophils [PDF]

, 2012
Eotaxin is a potent chemoattractant for eosinophils that becomes elevated in the tissues in response to inflammation and increased adiposity. Therefore, eosinophil migration into adipose tissue should increase in diet-induced obese individuals, yet it ...
Ashack, Kurt Anthony
core  

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders

Pharmaceuticals, 2020
Background: CCL-11 (eotaxin) is a chemokine with an important role in allergic conditions. Recent evidence indicates that CCL-11 plays a role in brain disorders as well.
Mariya Ivanovska, Zakee Abdi, Marianna Murdjeva, Danielle Macedo, Annabel Maes, Michael Maes   +5 more
doaj   +1 more source

Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Eotaxin, airway inflammation and hyperresponsiveness [PDF]

, 2001
Eotaxin is a chemokine involved in migration and activation of inflammatory cells. CC-chemokine receptor-3 (CCR3), the receptor for eotaxin and other chemokines, is expressed by a variety of cells, such as eosinophils, Th2 cells, basophils and mast cells.
Scheerens, J.
core   +16 more sources