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Current Topics in Medicinal Chemistry, 2020
The epidermal growth factor receptor (EGFR) belongs to ERBB family of tyrosine kinase receptor. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development.
D. Sabbah, Rima Hajjo, K. Sweidan
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The epidermal growth factor receptor (EGFR) belongs to ERBB family of tyrosine kinase receptor. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development.
D. Sabbah, Rima Hajjo, K. Sweidan
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Annals of the New York Academy of Sciences, 1982
During the course of purifying nerve growth factor from the submaxillary gland of the mouse, Cohen (1960) and Levi-Montalcini and Cohen (1960) noticed that daily injections of certain gland extract fractions into newborn mice produced developmental changes that could not be ascribed to nerve growth factor.
Graham Carpenter +2 more
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During the course of purifying nerve growth factor from the submaxillary gland of the mouse, Cohen (1960) and Levi-Montalcini and Cohen (1960) noticed that daily injections of certain gland extract fractions into newborn mice produced developmental changes that could not be ascribed to nerve growth factor.
Graham Carpenter +2 more
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Activation of Epidermal Growth Factor Receptor by Epidermal Growth Factor
Biochemistry, 1996The binding of epidermal growth factor (EGF) to epidermal growth factor receptor (EGF receptor) induces dimerization of the receptor and activation of its protein tyrosine kinase. Each of these three steps was followed as a function of the concentrations of EGF and of EGF receptor. Binding of EGF was followed by sedimentation of the complex between [3H]
Jennifer Miller Sherrill, Jack Kyte
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Cell Biology International, 1995
ABSTRACTEpidermal growth factor (EGF) is a single polypeptide of 53 amino acid residues which is involved in the regulation of cell proliferation. Egf exerts its effects in the target cells by binding to the plasma membrane located EGF receptor. The EGF receptor is a transmembrane protein tyrosine kinase.
Fons Cremers +5 more
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ABSTRACTEpidermal growth factor (EGF) is a single polypeptide of 53 amino acid residues which is involved in the regulation of cell proliferation. Egf exerts its effects in the target cells by binding to the plasma membrane located EGF receptor. The EGF receptor is a transmembrane protein tyrosine kinase.
Fons Cremers +5 more
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Epidermal Growth Factor, Epidermal Growth Factor Receptors, Intestinal Growth, and Adaptation
Journal of Parenteral and Enteral Nutrition, 1999Epidermal growth factor (EGF) is an important constituent of several gastrointestinal secretions. Many studies in both animals and humans have shown EGF to have multiple effects upon gut epithelial cells. These include cytoprotection, stimulatory effects on cell proliferation and migration, induction of gene expression such as mucosal enzymes and ...
Nicholas A. Wright, Wai Man Wong
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Epidermal growth factor receptors
Molecular and Cellular Biochemistry, 1981EGF-Rs are cell membrane glycoproteins of wide distribution. They have not yet been fully characterized or purified but are probably molecules of 170-190,000 mol. wt. in most cells. The growth factor EGF binds and will saturate cell surface receptors with a KA of about 5 X 10(9) M-1 although a receptor class with an affinity in excess of 10(10) M-1 has
Eileen D. Adamson, Anthony R. Rees
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, 1991 Polypeptide growth factors have attracted considerable interest since the initial description of nerve growth factor (NGF) in 1951 (Levi-Montalcini and Hamburger 1951) and, subsequently, the identification of epidermal growth factor (EGF) in 1962 (Cohen 1962).
I. Parikh, A. Guglietta, R. V. Nardi
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Baillière's Clinical Gastroenterology, 1996
Despite the wealth of information concerning EGF and its related peptides, its precise role in the control of gastrointestinal functions is still not fully resolved. However, there is no doubt that it can have some very potent effects on the gastrointestinal tract. These may be related to the control of growth and development and to the regular control
Nicholas A. Wright, Robert A. Goodlad
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Despite the wealth of information concerning EGF and its related peptides, its precise role in the control of gastrointestinal functions is still not fully resolved. However, there is no doubt that it can have some very potent effects on the gastrointestinal tract. These may be related to the control of growth and development and to the regular control
Nicholas A. Wright, Robert A. Goodlad
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Radioimmunoassay of Epidermal Growth Factor
Endocrinology, 1972Epidermal growth factor (EGF) is a biologically active polypeptide extracted from male mouse submaxillary glands. It exists either alone or complexed with an arginine esterase. It causes generalized epidermal growth and keratinization in the immature mouse and results in precocious tooth eruption and eye-opening that are the basis for an EGF bioassay ...
David N. Orth +2 more
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Epidermal Growth Factor and the Kidney
Annual Review of Physiology, 1989Current information indicates that the mammalian kidney is a significant site of EGF synthesis, second only to the salivary gland in the rodent and probably exceeding most other tissues in the human species. The prepro EGF mRNA is localized to the cells of the TALH and the DCT. The EGF mRNA transcript in kidney is similar to that in salivary gland; the
Delbert A. Fisher +2 more
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