Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients [PDF]
BMC Psychiatry, 2023 Background Schizophrenia (SCZ) is a severe and chronic psychiatric disorder with premature age-related physiological changes. However, numerous previous studies examined the epigenetic age acceleration in SCZ patients and yielded inconclusive results. In
Zongchang Li +6 more
doaj +3 more sources
Development of an epigenetic clock to predict visual age progression of human skin [PDF]
Frontiers in Aging, 2023 Aging is a complex process characterized by the gradual decline of physiological functions, leading to increased vulnerability to age-related diseases and reduced quality of life.
Agata Bienkowska +11 more
doaj +3 more sources
A Targeted Epigenetic Clock for the Prediction of Biological Age [PDF]
Cells, 2022 Epigenetic clocks were initially developed to track chronological age, but accumulating evidence indicates that they can also predict biological age.
Noémie Gensous +17 more
doaj +3 more sources
Influence of physical activity on the epigenetic clock: evidence from a Japanese cross-sectional study [PDF]
Clinical EpigeneticsBackground Biological age, especially epigenetic age derived from the epigenetic clock, is a significant measure of aging, considering the differences in aging rates among individuals.
Masatoshi Nagata +6 more
doaj +3 more sources
Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression. [PDF]
Genome Biol, 2022 Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG dinucleotides to accurately predict individual chronological age.
Jonkman TH +11 more
europepmc +5 more sources
Evaluation of pediatric epigenetic clocks across multiple tissues [PDF]
Clinical Epigenetics, 2023 Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
Fang Fang +28 more
doaj +5 more sources
Epigenetic clock and methylation studies in cats. [PDF]
Geroscience, 2021 Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles ...
Raj K +8 more
europepmc +4 more sources
Epigenetic clock as a correlate of anxiety [PDF]
NeuroImage: Clinical, 2020 DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one’s epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder ...
Klára Marečková +8 more
doaj +5 more sources
Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock. [PDF]
Aging Cell, 2022 Aging is associated with dramatic changes to DNA methylation (DNAm), although the causes and consequences of such alterations are unknown. Our ability to experimentally uncover mechanisms of epigenetic aging will be greatly enhanced by our ability to ...
Minteer C +8 more
europepmc +4 more sources
A pan-tissue DNA-methylation epigenetic clock based on deep learning [PDF]
NPJ Aging, 2022 Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been created in recent years, with the vast majority based on regularized linear regression.
de Lima Camillo L, Lapierre L, Singh R.
europepmc +4 more sources