Results 1 to 10 of about 14,358 (94)

Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients [PDF]

BMC Psychiatry, 2023
Background Schizophrenia (SCZ) is a severe and chronic psychiatric disorder with premature age-related physiological changes. However, numerous previous studies examined the epigenetic age acceleration in SCZ patients and yielded inconclusive results. In
Zongchang Li, Xiaofen Zong, David Li, Ying He, Jinsong Tang, Maolin Hu, Xiaogang Chen   +6 more
doaj   +2 more sources

A Targeted Epigenetic Clock for the Prediction of Biological Age [PDF]

Cells, 2022
Epigenetic clocks were initially developed to track chronological age, but accumulating evidence indicates that they can also predict biological age.
Noémie Gensous, Claudia Sala, Chiara Pirazzini, Francesco Ravaioli, Maddalena Milazzo, Katarzyna Malgorzata Kwiatkowska, Elena Marasco, Sara De Fanti, Cristina Giuliani, Camilla Pellegrini, Aurelia Santoro, Miriam Capri, Stefano Salvioli, Daniela Monti, Gastone Castellani, Claudio Franceschi, Maria Giulia Bacalini, Paolo Garagnani   +17 more
doaj   +2 more sources

Development of an epigenetic clock to predict visual age progression of human skin [PDF]

Frontiers in Aging, 2023
Aging is a complex process characterized by the gradual decline of physiological functions, leading to increased vulnerability to age-related diseases and reduced quality of life.
Agata Bienkowska, Agata Bienkowska, Günter Raddatz, Jörn Söhle, Boris Kristof, Henry Völzke, Stefan Gallinat, Frank Lyko, Lars Kaderali, Marc Winnefeld, Elke Grönniger, Cassandra Falckenhayn   +11 more
doaj   +2 more sources

Influence of physical activity on the epigenetic clock: evidence from a Japanese cross-sectional study [PDF]

Clinical Epigenetics
Background Biological age, especially epigenetic age derived from the epigenetic clock, is a significant measure of aging, considering the differences in aging rates among individuals.
Masatoshi Nagata, Shohei Komaki, Yuichiro Nishida, Hideki Ohmomo, Megumi Hara, Keitaro Tanaka, Atsushi Shimizu   +6 more
doaj   +2 more sources

Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids

Communications Biology, 2021
Larison et al. report epigenetic aging models in plains zebras (Equus quagga) using the epigenetic clock and epigenetic pacemaker approaches. Their epigenetic clock allows age to be accurately estimated in endangered sister species, and the pacemaker ...
Brenda Larison, Gabriela M. Pinho, Amin Haghani, Joseph A. Zoller, Caesar Z. Li, Carrie J. Finno, Colin Farrell, Christopher B. Kaelin, Gregory S. Barsh, Bernard Wooding, Todd R. Robeck, Dewey Maddox, Matteo Pellegrini, Steve Horvath   +13 more
doaj   +1 more source

The pediatric buccal epigenetic clock identifies significant ageing acceleration in children with internalizing disorder and maltreatment exposure

Neurobiology of Stress, 2021
Background: Studies reporting accelerated ageing in children with affective disorders or maltreatment exposure have relied on algorithms for estimating epigenetic age derived from adult samples.
Felix Dammering, Jade Martins, Katja Dittrich, Darina Czamara, Monika Rex-Haffner, Judith Overfeld, Karin de Punder, Claudia Buss, Sonja Entringer, Sibylle M. Winter, Elisabeth B. Binder, Christine Heim   +11 more
doaj   +1 more source

Evaluation of pediatric epigenetic clocks across multiple tissues

Clinical Epigenetics, 2023
Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie-France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O’Connor, Douglas M. Ruden, Leonardo Trasande, Julie B. Herbstman, Carlos A. Camargo, Nicole R. Bush, Anne L. Dunlop, Dana M. Dabelea, Margaret R. Karagas, Carrie V. Breton, Carole Ober, Todd M. Everson, Grier P. Page, Christine Ladd-Acosta, on behalf of program collaborators for Environmental influences on Child Health Outcomes   +28 more
doaj   +1 more source

Epigenetic clock as a correlate of anxiety

NeuroImage: Clinical, 2020
DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one’s epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder ...
Klára Marečková, Anna Pačínková, Anja Klasnja, Jean Shin, Lenka Andrýsková, Kateřina Stano-Kozubík, Zdenka Pausová, Milan Brázdil, Tomáš Paus   +8 more
doaj   +1 more source

An Epigenetic Aging Clock for Cattle Using Portable Sequencing Technology

Frontiers in Genetics, 2021
Extensively grazed cattle are often mustered only once a year. Therefore, birthdates are typically unknown or inaccurate. Birthdates would be useful for deriving important traits (growth rate; calving interval), breed registrations, and making management
Ben J. Hayes, Loan T. Nguyen, Mehrnush Forutan, Bailey N. Engle, Harrison J. Lamb, James P. Copley, Imtiaz A. S. Randhawa, Elizabeth M. Ross   +7 more
doaj   +1 more source

Dynamic epigenetic age mosaicism in the human atherosclerotic artery

PLoS ONE, 2022
Accelerated epigenetic ageing, a promising marker of disease risk, has been detected in peripheral blood cells of atherosclerotic patients, but evidence in the vascular wall is lacking.
Silvio Zaina, Manel Esteller, Isabel Gonçalves, Gertrud Lund   +3 more
doaj   +3 more sources