Roles of physical exercise in neurodegeneration: reversal of epigenetic clock [PDF]
Translational Neurodegeneration, 2021 The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age.
Miao Xu +4 more
doaj +3 more sources
Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock [PDF]
Genome Biology, 2022 Background A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples.
James E. Barrett +14 more
doaj +3 more sources
Region-based epigenetic clock design improves RRBS-based age prediction. [PDF]
Aging Cell, 2023 Recent studies suggest that epigenetic rejuvenation can be achieved using drugs that mimic calorie restriction and techniques such as reprogramming induced rejuvenation.
Simpson DJ +6 more
europepmc +3 more sources
A Review of the Epigenetic Clock: Emerging Biomarkers for Asthma and Allergic Disease. [PDF]
Genes (Basel), 2023 DNA methylation (DNAm) is a dynamic, age-dependent epigenetic modification that can be used to study interactions between genetic and environmental factors. Environmental exposures during critical periods of growth and development may alter DNAm patterns,
Vasileva D, Greenwood CMT, Daley D.
europepmc +2 more sources
Effect of women's fertility and sexual development on epigenetic clock: Mendelian randomization study. [PDF]
Clin Epigenetics, 2023 Background and objectives In observational studies, women’s fertility and sexual development traits may have implications for DNA methylation patterns, and pregnancy-related risk factors can also affect maternal DNA methylation patterns.
Zhang B, Yuan Q, Luan Y, Xia J.
europepmc +2 more sources
An evolutionary epigenetic clock in plants
Science, 2023 Molecular clocks are the basis for dating the divergence between lineages over macro-evolutionary timescales (~105-108 years). However, classical DNA-based clocks tick too slowly to inform us about the recent past.
N. Yao +12 more
semanticscholar +7 more sources
Distinguishable DNA methylation defines a cardiac-specific epigenetic clock. [PDF]
Clin Epigenetics, 2023 Background The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG).
Mongelli A +20 more
europepmc +2 more sources
Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice. [PDF]
Int J Mol Sci, 2023 The homozygous genotype of the Longevity-Associated Variant (LAV) in Bactericidal/Permeability-Increasing Fold-Containing Family B member 4 (BPIFB4) is enriched in long-living individuals of three independent populations and its genetic transfer in C57BL/
Giuliani ME +14 more
europepmc +2 more sources
Development of an epigenetic clock resistant to changes in immune cell composition. [PDF]
Commun BiolEpigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age acceleration) are ...
Tomusiak A +7 more
europepmc +2 more sources
An epigenetic clock for human skeletal muscle [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues.
Sarah Voisin +15 more
doaj +6 more sources