Results 11 to 20 of about 14,860 (271)

An epigenetic clock for human skeletal muscle [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2020
Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues.
Sarah Voisin, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Vernon G. Coffey, Thomas M. Doering, Jamie‐Lee M. Thompson, Christian Benedict, Jonathan Cedernaes, Malene E. Lindholm, Jeffrey M. Craig, David S. Rowlands, Adam P. Sharples, Steve Horvath, Nir Eynon   +15 more
doaj   +7 more sources

Epigenetic clock as a correlate of anxiety

NeuroImage: Clinical, 2020
DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one’s epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder ...
Klára Marečková, Anna Pačínková, Anja Klasnja, Jean Shin, Lenka Andrýsková, Kateřina Stano-Kozubík, Zdenka Pausová, Milan Brázdil, Tomáš Paus   +8 more
doaj   +3 more sources

Calibrating epigenetic clocks with training data error

Evolutionary Applications, 2023
Animal age data are valuable for management of wildlife populations. Yet, for most species, there is no practical method for determining the age of unknown individuals.
Benjamin Mayne, Oliver Berry, Simon Jarman   +2 more
doaj   +3 more sources

Developmental Tuning of Epigenetic Clock [PDF]

Frontiers in Genetics, 2018
Research in the field of gerontology has traditionally focused on later life stages. There is increasing evidence, however, that both the rate of age-related functional decline and the later-life health status can be programmed during early development ...
Alexander Vaiserman
doaj   +3 more sources

A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. [PDF]

Nat Aging
Fuentealba M, Rouch L, Guyonnet S, Lemaitre JM, de Souto Barreto P, Vellas B, Andrieu S, Furman D.   +7 more
europepmc   +3 more sources

Epigenetic events influencing the biological clock: Panacea for neurodegeneration

Heliyon
The human biological clock is the 24-h internal molecular network of circadian genes in synchronization with other cells in response to external stimuli.
Indrani Paramasivan Latha Laxmi, Ramasamy Tamizhselvi   +1 more
doaj   +2 more sources

TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction. [PDF]

Nat Aging
Griffin PT, Kane AE, Trapp A, Li J, Arnold M, Poganik JR, Conway RJ, McNamara MS, Meer MV, Hoffman N, Amorim JA, Tian X, MacArthur MR, Mitchell SJ, Mueller AL, Carmody C, Vera DL, Kerepesi C, Ying K, Noren Hooten N, Mitchell JR, Evans MK, Gladyshev VN, Sinclair DA.   +23 more
europepmc   +3 more sources

Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort. [PDF]

Alzheimers Dement (Amst)
Savin MJ, Wang H, Pei H, Aiello AE, Assuras S, Caspi A, Moffitt TE, Muenning PA, Ryan CP, Shi B, Stern Y, Sugden K, Valeri L, Belsky DW.   +13 more
europepmc   +3 more sources

An epigenetic clock for Xenopus tropicalis. [PDF]

NPJ Aging
Abstract DNA methylation clocks have been widely used for accurate age prediction, but most studies have been carried out on mammals. Here we present an epigenetic clock for the aquatic frog Xenopus tropicalis, a widely used model organism in developmental biology and genomics.
Bennett R, Morselli M, Petrova K, Peshkin L, Pellegrini M.   +4 more
europepmc   +3 more sources

Epigenetic Clocks and Programmatic Aging

Ageing Research Reviews, 2023
The last decade has seen remarkable progress in the characterization of methylation clocks that track biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms.
David Gems, Roop Singh Virk, João Pedro de Magalhães   +2 more
openaire   +2 more sources