Results 21 to 30 of about 14,428 (154)

Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells

Nature Communications, 2022
The temporal development of tissues and organs may be defined by the genome-wide epigenetic and transcriptional state functioning as the clock. Here the authors found that Fbl, a ribosomal RNA methyltransferase, potentially behaves as a clock during ...
Quan Wu, Yuichi Shichino, Takaya Abe, Taeko Suetsugu, Ayaka Omori, Hiroshi Kiyonari, Shintaro Iwasaki, Fumio Matsuzaki   +7 more
doaj   +1 more source

An evolutionary epigenetic clock in plants

Science, 2023
Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (~10 5 to 10 8 years). However, classical DNA-based clocks tick too slowly to inform us about the recent past.
Yao, N., Zhang, Z., Yu, L., Hazarika, R., Yu, C., Jang, H., Smith, L.M., Ton, J., Liu, L., Stachowicz, J.J., Reusch, T.B.H., Schmitz, R.J., Johannes, F.   +12 more
openaire   +7 more sources

Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus

Frontiers in Genetics, 2022
Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited.
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
doaj   +1 more source

Circadian clock: linking epigenetics to aging [PDF]

Current Opinion in Genetics & Development, 2014
Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features.
Orozco-Solis, Ricardo, Sassone-Corsi, Paolo   +1 more
openaire   +4 more sources

Epigenetic clock and methylation studies in cats. [PDF]

Geroscience, 2021
Abstract Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles underpinning them appear to be conserved even in ...
Raj K, Szladovits B, Haghani A, Zoller JA, Li CZ, Black P, Maddox D, Robeck TR, Horvath S.   +8 more
europepmc   +6 more sources

Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity

GeroScience, 2023
Abstract Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than ...
Dec, Eric, Clement, James, Cheng, Kaiyang, Church, George M., Fossel, Michael B., Rehkopf, David H., Rosero-Bixby, Luis, Kobor, Michael S., Lin, David TS., Lu, Ake T., Fei, Zhe, Guo, Wei, Chew, Yap Ching, Yang, Xiaojing, Putra, Sulistyo E. Dwi, Reiner, Alex P., Correa, Adolfo, Vilalta, Adrian, Pirazzini, Chiara, Passarino, Giuseppe, Monti, Daniela, Arosio, Beatrice, Garagnani, Paolo, Franceschi, Claudio, Horvath, Steve   +24 more
openaire   +6 more sources

Epigenetic clock and methylation studies in elephants. [PDF]

Aging Cell, 2021
ABSTRACTAge-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age (“epigenetic clocks”) in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants.
Prado NA, Brown JL, Zoller JA, Haghani A, Yao M, Bagryanova LR, Campana MG, E Maldonado J, Raj K, Schmitt D, Robeck TR, Horvath S.   +11 more
europepmc   +4 more sources

Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination

Frontiers in Genetics, 2022
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence suggest that severe COVID-19 is associated with durable scars to the epigenome.
Alina P. S. Pang, Albert T. Higgins-Chen, Albert T. Higgins-Chen, Florence Comite, Florence Comite, Ioana Raica, Christopher Arboleda, Hannah Went, Tavis Mendez, Michael Schotsaert, Michael Schotsaert, Varun Dwaraka, Ryan Smith, Morgan E. Levine, Lishomwa C. Ndhlovu, Michael J. Corley   +15 more
doaj   +1 more source

Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

Genome Biology, 2019
Background Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate biomarkers of the aging process.
Daniel E. Martin-Herranz, Erfan Aref-Eshghi, Marc Jan Bonder, Thomas M. Stubbs, Sanaa Choufani, Rosanna Weksberg, Oliver Stegle, Bekim Sadikovic, Wolf Reik, Janet M. Thornton   +9 more
doaj   +1 more source

A Novel Loop: Mutual Regulation Between Epigenetic Modification and the Circadian Clock

Frontiers in Plant Science, 2019
In response to periodic environmental fluctuations generated by the rotation of the earth, nearly all organisms have evolved an intrinsic timekeeper, the circadian clock, which can maintain approximate 24-h rhythmic oscillations in biological processes ...
Shenxiu Du, Liang Chen, Liangfa Ge, Wei Huang   +3 more
doaj   +1 more source