Building Minimized Epigenetic Clock by iPlex MassARRAY Platform. [PDF]
Genes (Basel)Epigenetic clocks are valuable tools for estimating both chronological and biological age by assessing DNA methylation levels at specific CpG dinucleotides.
Davydova E, Perenkov A, Vedunova M.
europepmc +2 more sources
Sperm epigenetic clock associates with pregnancy outcomes in the general population. [PDF]
Hum Reprod, 2022 STUDY QUESTION Is sperm epigenetic aging (SEA) associated with probability of pregnancy among couples in the general population? SUMMARY ANSWER We observed a 17% lower cumulative probability at 12 months for couples with male partners in the older ...
Pilsner JR +8 more
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Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation. [PDF]
Aging (Albany NY)Changes in DNA methylation with age are observed across the tree of life. The stereotypical nature of these changes can be modeled to produce epigenetic clocks capable of predicting chronological age with unprecedented accuracy.
Bertucci-Richter EM +2 more
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An ELOVL2-Based Epigenetic Clock for Forensic Age Prediction: A Systematic Review. [PDF]
Int J Mol Sci, 2023 The prediction of chronological age from methylation-based biomarkers represents one of the most promising applications in the field of forensic sciences. Age-prediction models developed so far are not easily applicable for forensic caseworkers.
Paparazzo E +8 more
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Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients. [PDF]
Front Aging Neurosci, 2022 Background Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS) characterized by irreversible disability at later progressive stages.
Kular L +7 more
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An epigenetic clock controls aging [PDF]
Biogerontology, 2015 We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control. We have seen that signaling chemistry can
Mitteldorf, Joshua
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Does Modulation of an Epigenetic Clock Define a Geroprotector? [PDF]
Adv Geriatr Med Res, 2022 There is growing interest in the development of interventions (e.g., drugs, diets, dietary supplements, behavioral therapies, etc.) that can enhance health during the aging process, prevent or delay multiple age-related diseases, and ultimately extend ...
Schork NJ +4 more
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Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1 [PDF]
Genome Biology, 2019 Background Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate biomarkers of the aging process.
Daniel E. Martin-Herranz +9 more
doaj +6 more sources
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies. [PDF]
Geroscience, 2022 The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial.
Horvath S +14 more
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Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age. [PDF]
Biology (Basel), 2022 Simple Summary Biological age (B-age), or the degree of aging of an individual, can differ from chronological age. B-age is affected by epigenetics, and we calculate it based on the degree of methylation of multiple specific regions of human DNA.
Jiménez-Balado J +17 more
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