Results 31 to 40 of about 14,428 (154)

An epigenetic clock controls aging [PDF]

Biogerontology, 2015
We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control. We have seen that signaling chemistry can make dramatic differences in life span, and that single molecules can significantly affect ...
openaire   +3 more sources

Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

Translational Neurodegeneration, 2021
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age.
Miao Xu, JiaYi Zhu, Xian-Dong Liu, Ming-Ying Luo, Nan-Jie Xu   +4 more
doaj   +1 more source

Estimating Polar Bear (Ursus maritimus) Age Based on an Epigenetic DNA Methylation Clock

Ecology and Evolution
Knowledge of animal age is essential to wildlife managers for obtaining meaningful and accurate insights into demographic parameters. A common approach to aging wildlife, including bears (Ursus spp.), has been extracting a tooth during physical capture ...
Susannah P. Woodruff, Milda Milčiūtė, Juozas Gordevičius, Robert Brooke, Todd C. Atwood   +4 more
doaj   +1 more source

Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial)

Scientific Reports
Plasmapheresis is a medical procedure that separates plasma from blood cells, potentially removing pro-aging factors from circulation. Some studies suggest it may have rejuvenating effects by altering biomarkers of aging, but evidence on its impact on ...
Pavel Borsky, Drahomira Holmannova, Helena Parova, Steve Horvath, Petr Sramek, Robert T. Brooke, Milda Milciute, Juozas Gordevicius, Zdenek Fiala, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Ivana Baranova, Natalia Matyasovska, Lenka Borska   +14 more
doaj   +1 more source

Multi-tissue DNA methylation age predictor in mouse

Genome Biology, 2017
Background DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an underlying ageing process.
Thomas M. Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, BI Ageing Clock Team, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik   +7 more
doaj   +1 more source

Epigenetic clock analysis in long-term meditators [PDF]

Psychoneuroendocrinology, 2017
In this paper, we examined whether meditation practice influences the epigenetic clock, a strong and reproducible biomarker of biological aging, which is accelerated by cumulative lifetime stress and with age-related chronic diseases. Using the Illumina 450K array platform, we analyzed the DNA methylome from blood cells of long-term meditators and ...
Chaix, Raphaëlle, Alvarez-López, Maria Jesús, Fagny, Maud, Lemee, Laure, Regnault, Béatrice, Davidson, Richard, Lutz, Antoine, Kaliman, Perla   +7 more
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DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples

Communications Biology
This study aims to evaluate differences between Infinium MethylationEPIC (EPICv1) and Infinium MethylationEPICv2 (EPICv2) arrays in estimating DNAm age with eleven DNAm clocks using buffy coat, peripheral blood mononuclear cell (PBMC), and saliva from 16
Jian Hua Tay, Yi Ern Chew, Weilan Wang, Zhi Meng Lim, Lihuan Guan, Rajkumar Dorajoo, Brian K. Kennedy, Robert Brooke, Juozas Gordevicius, Steve Horvath, Elena Sandalova, Andrea B. Maier   +11 more
doaj   +1 more source

Effects of Maternal Vitamin D3 Supplementation on Offspring Epigenetic Clock of Gestational Age at Birth: A Post-hoc Analysis of a Randomized Controlled Trial

Epigenetics, 2020
Vitamin D could be beneficial for healthy ageing in humans. We previously found that vitamin D supplementation may slow down epigenetic ageing in young African American adults.
Li Chen, Carol L. Wagner, Yanbin Dong, Xiaoling Wang, Judith R. Shary, Ying Huang, Bruce W. Hollis, Haidong Zhu   +7 more
doaj   +1 more source

An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-moderate probable Alzheimer's disease

Frontiers in Neuroscience
IntroductionAging is the primary risk factor for sporadic Alzheimer's disease. Chronic low-grade inflammation associated with aging drives cognitive impairment through multiple mechanisms involving oxidative stress, insulin resistance, and dysregulation ...
Christopher L. Reading, Jiayan Yan, Marcia A. Testa, Donald C. Simonson, Hira Javaid, Lisa Schmunk, Daniel E. Martin-Herranz, Robert Brooke, Juozas Gordevicius, Jeffrey Zhang, Harvey Yuan, Clarence Ahlem, Lixia Wang, Penelope Markham, Nily Osman, Stephen O'Quinn, Joseph Palumbo   +16 more
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Age-dependent methylation in epigenetic clock CpGs is associated with G-quadruplex, co-transcriptionally formed RNA structures and tentative splice sites

Epigenetics, 2018
Horvath’s epigenetic clock consists of 353 CpGs whose methylation levels can accurately predict the age of individuals. Using bioinformatics analysis, we investigated the conformation, energy characteristics and presence of tentative splice sites of the ...
Andigoni Malousi, Alexandra-Zoi Andreou, Elisavet Georgiou, Georgios Tzimagiorgis, Leda Kovatsi, Sofia Kouidou   +5 more
doaj   +1 more source