Results 31 to 40 of about 431,319 (321)
How alcohol makes the epigenetic clock tick faster and the clock reversing effect of abstinence [PDF]
Addiction Biology, 2022 This study investigated the recently reported association between alcohol dependence and accelerated ageing and the potential effects of abstinence and relapse on DNA methylation status using Levine's epigenetic clock to estimate DNA methylation age in ...
Tristan Zindler +8 more
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Developmental Tuning of Epigenetic Clock [PDF]
Frontiers in Genetics, 2018 Research in the field of gerontology has traditionally focused on later life stages. There is increasing evidence, however, that both the rate of age-related functional decline and the later-life health status can be programmed during early development ...
Alexander Vaiserman
doaj +4 more sources
Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration. [PDF]
Front Med (Lausanne), 2022 Age-Related Macular Degeneration (AMD) is a bilateral ocular condition resulting in irreversible vision impairment caused by the progressive loss of photoreceptors in the macula, a region at the center of the retina. The progressive loss of photoreceptor
Mallik S +4 more
europepmc +2 more sources
Rejuvenation by cell reprogramming: a new horizon in gerontology [PDF]
Stem Cell Research & Therapy, 2018 The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here,
Rodolfo G. Goya +5 more
doaj +4 more sources
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Aging, 2017 Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates.
Austin Quach +20 more
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Accelerated epigenetic clock aging in maternal peripheral blood and preterm birth. [PDF]
Am J Obstet Gynecol, 2023 Gascoigne EL +4 more
europepmc +2 more sources
Correlation of an epigenetic mitotic clock with cancer risk. [PDF]
Genome Biology, 2016 BACKGROUND: Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be influenced by extrinsic factors ...
Beck, Stephan +9 more
core +9 more sources
Epigenetic Clock: DNA Methylation in Aging [PDF]
Stem Cells International, 2020 Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years.
Shuang Jiang, Yuchen Guo
doaj +4 more sources
TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction. [PDF]
Nat AgingGriffin PT +23 more
europepmc +2 more sources
An epigenetic clock for human skeletal muscle [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2019 AbstractBackgroundAgeing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the original pan-tissue epigenetic clock did not include skeletal muscle samples, and hence exhibited a strong deviation between ...
Sarah Voisin +15 more
openalex +12 more sources