Results 41 to 50 of about 431,319 (321)

Epigenetic Clocks Are Not Accelerated in COVID-19 Patients [PDF]

International Journal of Molecular Sciences, 2021
AbstractAge is a major risk factor for severe outcome of coronavirus disease 2019 (COVID-19), but it remains unclear if this is rather due to increased chronological age or biological age. During lifetime, specific DNA methylation changes are acquired in our genome that act as “epigenetic clocks” allowing to estimate donor age and to provide a ...
Julia Franzen, Selina Nüchtern, Vithurithra Tharmapalan, Margherita Vieri, Miloš Nikolić, Yang Han, Paul Balfanz, Nikolaus Marx, Michael Dreher, Tim H. Brümmendorf, Edgar Dahl, Fabian Beier, Wolfgang Wagner   +12 more
openalex   +8 more sources

Asthma, Gender and the Epigenetic Clock [PDF]

A32. ASTHMA CLINICAL STUDIES, 2020
Denise Daley, Denitsa Vasileva, Mimi Wan, A.B. Becker, Elaine Chan, Catherine Laprise, P. D. Paré, Christopher Greenwood, ANDREW J. SANDFORD   +8 more
openalex   +2 more sources

A common epigenetic clock from childhood to old age [PDF]

Forensic Science International: Genetics, 2022
A. Freire-Aradas, Lorena Girón-Santamaría, Ana Mosquera‐Miguel, A. Ambroa-Conde, Christopher Phillips, Magdalena Cal, Antonio Gómez‐Tato, José Antonio Álvarez‐Dios, Ewelina Pośpiech, Anastasia Aliferi, Denise Syndercombe Court, Wojciech Branicki, M.V. Lareu   +12 more
openalex   +2 more sources

Cardiovascular health and four epigenetic clocks [PDF]

Clinical Epigenetics, 2022
Abstract Background Cardiovascular health (CVH) was defined by the American Heart Association as an integrative idealness of seven clinical or lifestyle factors. Based on populations of European ancestry, recent studies have shown that ideal CVH is associated with a slower aging rate. The aging rate is measured by levels
Yun-Hsiang Lo, Wan‐Yu Lin
openalex   +3 more sources

Perfect timing: Epigenetic regulation of the circadian clock [PDF]

FEBS Letters, 2011
In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post‐genetic molecular mechanism is one of the routes by which phenotype is shaped.
Jürgen A. Ripperger, Martha Merrow
openalex   +4 more sources

An epigenetic aging clock for dogs and wolves

Aging, 2017
Several articles describe highly accurate age estimation methods based on human DNA-methylation data. It is not yet known whether similar epigenetic aging clocks can be developed based on blood methylation data from canids. Using Reduced Representation Bisulfite Sequencing, we assessed blood DNA-methylation data from 46 domesticated dogs (Canis ...
Michael J. Thompson, Bridgett M. vonHoldt, Steve Horvath, Matteo Pellegrini   +3 more
openalex   +6 more sources

Epigenetic clock and methylation studies in elephants. [PDF]

Aging Cell, 2021
ABSTRACTAge-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age (“epigenetic clocks”) in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants.
Prado NA, Brown JL, Zoller JA, Haghani A, Yao M, Bagryanova LR, Campana MG, E Maldonado J, Raj K, Schmitt D, Robeck TR, Horvath S.   +11 more
europepmc   +6 more sources

Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids

Communications Biology, 2021
Larison et al. report epigenetic aging models in plains zebras (Equus quagga) using the epigenetic clock and epigenetic pacemaker approaches. Their epigenetic clock allows age to be accurately estimated in endangered sister species, and the pacemaker ...
Brenda Larison, Gabriela M. Pinho, Amin Haghani, Joseph A. Zoller, Caesar Z. Li, Carrie J. Finno, Colin Farrell, Christopher B. Kaelin, Gregory S. Barsh, Bernard Wooding, Todd R. Robeck, Dewey Maddox, Matteo Pellegrini, Steve Horvath   +13 more
doaj   +1 more source

Epigenetic clock in the aorta and age-related endothelial dysfunction in mice. [PDF]

Geroscience
Pośpiech E, Bar A, Pisarek-Pacek A, Karaś A, Branicki W, Chlopicki S.   +5 more
europepmc   +3 more sources

Development of a novel epigenetic clock resistant to changes in immune cell composition

bioRxiv, 2023
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age acceleration) are ...
Alan Tomusiak, Ariel Floro, R. Tiwari, R. Riley, Hiroyuki Matsui, Nicolas Andrews, H. Kasler, E. Verdin   +7 more
semanticscholar   +1 more source