Results 41 to 50 of about 14,428 (154)

The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes

Neurobiology of Disease, 2021
Epigenetic clocks are calculated by combining DNA methylation states across select CpG sites to estimate biologic age, and have been noted as the most successful markers of biologic aging to date.
Francine Grodstein, Bernardo Lemos, Lei Yu, Hans-Ulrich Klein, Artemis Iatrou, Aron S. Buchman, Gemma L. Shireby, Jonathan Mill, Julie A. Schneider, Philip L. De Jager, David A. Bennett   +10 more
doaj   +1 more source

Epigenetic/circadian clocks and PCOS

Human Reproduction
Abstract Polycystic ovary syndrome (PCOS) affects 6–20% of reproductive-aged women. It is associated with increased risks of metabolic syndrome, Type 2 diabetes, cardiovascular diseases, mood disorders, endometrial cancer and non-alcoholic fatty liver disease.
Camille Vatier, Sophie Christin-Maitre
openaire   +3 more sources

Circadian Regulation of Immunity Through Epigenetic Mechanisms

Frontiers in Cellular and Infection Microbiology, 2020
The circadian clock orchestrates daily rhythms in many physiological, behavioral and molecular processes, providing means to anticipate, and adapt to environmental changes.
Ricardo Orozco-Solis, Lorena Aguilar-Arnal   +1 more
doaj   +1 more source

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Genome Biology, 2022
Background A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples.
James E. Barrett, Chiara Herzog, Yoo-Na Kim, Thomas E. Bartlett, Allison Jones, Iona Evans, David Cibula, Michal Zikan, Line Bjørge, Nadia Harbeck, Nicoletta Colombo, Sacha J. Howell, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Martin Widschwendter   +14 more
doaj   +1 more source

Age estimation in fishes using epigenetic clocks: Applications to fisheries management and conservation biology

Frontiers in Marine Science, 2023
The distribution of age classes is a key demographic parameter of populations and thus proper age estimation is crucial for fisheries management and for conservation biology.
Francesc Piferrer, Dafni Anastasiadi
doaj   +1 more source

Perfect timing: Epigenetic regulation of the circadian clock [PDF]

FEBS Letters, 2011
In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post‐genetic molecular mechanism is one of the routes by which phenotype is shaped.
Ripperger Jürgen A, Merrow Martha
openaire   +2 more sources

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

Genome Biology, 2017
Background Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by ...
Tina Wang, Brian Tsui, Jason F. Kreisberg, Neil A. Robertson, Andrew M. Gross, Michael Ku Yu, Hannah Carter, Holly M. Brown-Borg, Peter D. Adams, Trey Ideker   +9 more
doaj   +1 more source

Time's up: Epigenetic clocks in plants

Current Opinion in Plant Biology
For over a decade, the animal field has led the way in using DNA methylation measurements to construct epigenetic clocks of aging. These clocks can predict organismal age with a level of accuracy that surpasses any other molecular proxy known to date. Evidence is finally emerging that epigenetic clocks also exist in plants. However, these clocks appear
Vo, Binh Thanh, Más, Paloma, Johannes, Frank   +2 more
openaire   +3 more sources

A new timepiece: an epigenetic mitotic clock

Genome Biology, 2016
A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.
Christensen, Brock C., Kelsey, Karl T.
openaire   +2 more sources

Distinct epigenetic aging in sporadic and hereditary neuroendocrine neoplasms

Clinical Epigenetics
Background Epigenetic clocks assess DNA aging based on DNA methylation. We aimed to study the utility of methylation clocks in understanding the distinct characteristics of sporadic and hereditary neuroendocrine neoplasms (NEN).
Shiri Weinstein, Reut Halperin, Amit Tirosh   +2 more
doaj   +1 more source