Results 41 to 50 of about 14,860 (271)

Multi-tissue DNA methylation age predictor in mouse

Genome Biology, 2017
Background DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an underlying ageing process.
Thomas M. Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, BI Ageing Clock Team, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik   +7 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial)

Scientific Reports
Plasmapheresis is a medical procedure that separates plasma from blood cells, potentially removing pro-aging factors from circulation. Some studies suggest it may have rejuvenating effects by altering biomarkers of aging, but evidence on its impact on ...
Pavel Borsky, Drahomira Holmannova, Helena Parova, Steve Horvath, Petr Sramek, Robert T. Brooke, Milda Milciute, Juozas Gordevicius, Zdenek Fiala, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Ivana Baranova, Natalia Matyasovska, Lenka Borska   +14 more
doaj   +1 more source

Effects of Maternal Vitamin D3 Supplementation on Offspring Epigenetic Clock of Gestational Age at Birth: A Post-hoc Analysis of a Randomized Controlled Trial

Epigenetics, 2020
Vitamin D could be beneficial for healthy ageing in humans. We previously found that vitamin D supplementation may slow down epigenetic ageing in young African American adults.
Li Chen, Carol L. Wagner, Yanbin Dong, Xiaoling Wang, Judith R. Shary, Ying Huang, Bruce W. Hollis, Haidong Zhu   +7 more
doaj   +1 more source

Epigenetic clock analysis in long-term meditators [PDF]

Psychoneuroendocrinology, 2017
In this paper, we examined whether meditation practice influences the epigenetic clock, a strong and reproducible biomarker of biological aging, which is accelerated by cumulative lifetime stress and with age-related chronic diseases. Using the Illumina 450K array platform, we analyzed the DNA methylome from blood cells of long-term meditators and ...
Chaix, Raphaëlle, Alvarez-López, Maria Jesús, Fagny, Maud, Lemee, Laure, Regnault, Béatrice, Davidson, Richard, Lutz, Antoine, Kaliman, Perla   +7 more
openaire   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples

Communications Biology
This study aims to evaluate differences between Infinium MethylationEPIC (EPICv1) and Infinium MethylationEPICv2 (EPICv2) arrays in estimating DNAm age with eleven DNAm clocks using buffy coat, peripheral blood mononuclear cell (PBMC), and saliva from 16
Jian Hua Tay, Yi Ern Chew, Weilan Wang, Zhi Meng Lim, Lihuan Guan, Rajkumar Dorajoo, Brian K. Kennedy, Robert Brooke, Juozas Gordevicius, Steve Horvath, Elena Sandalova, Andrea B. Maier   +11 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-moderate probable Alzheimer's disease

Frontiers in Neuroscience
IntroductionAging is the primary risk factor for sporadic Alzheimer's disease. Chronic low-grade inflammation associated with aging drives cognitive impairment through multiple mechanisms involving oxidative stress, insulin resistance, and dysregulation ...
Christopher L. Reading, Jiayan Yan, Marcia A. Testa, Donald C. Simonson, Hira Javaid, Lisa Schmunk, Daniel E. Martin-Herranz, Robert Brooke, Juozas Gordevicius, Jeffrey Zhang, Harvey Yuan, Clarence Ahlem, Lixia Wang, Penelope Markham, Nily Osman, Stephen O'Quinn, Joseph Palumbo   +16 more
doaj   +1 more source