Results 81 to 90 of about 431,319 (321)

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

From implantation to birth: insight into molecular melatonin functions [PDF]

, 2018
Melatonin is a lipophilic hormone synthesized and secreted mainly in the pineal gland, acting as a neuroendocrine transducer of photoperiodic information during the night.
Carlomagno, Gianfranco, Minini, Mirko, Tilotta, Marco, Unfer, Vittorio   +3 more
core   +1 more source

Epigenetic clock analysis and increased plasminogen activator inhibitor-1 in high-functioning autism spectrum disorder

PLoS ONE, 2022
Background Autism spectrum disorder (ASD) is characterized by impaired social communication and behavioral problems. An increased risk of premature mortality has been observed in individuals with ASD.
S. Okazaki, Ryo Kimura, Ikuo Otsuka, Yasuko Funabiki, T. Murai, A. Hishimoto   +5 more
semanticscholar   +1 more source

Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years [PDF]

, 2023
BACKGROUND: Accelerated epigenetic ageing can occur in untreated HIV infection and is partially reversible with effective antiretroviral therapy (ART).
Arribas, José R, Bernasconi, Enos, Braun, Dominique L, Buvelot, Hélène, Cavassini, Matthias, Esteban-Cantos, Andrés, Fellay, Jacques, Günthard, Huldrych F, Kouyos, Roger D, Ledergerber, Bruno, Marzolini, Catia, Reiss, Peter, Riebensahm, Carlotta, Rodríguez-Centeno, Javier, Rodés, Berta, Schoepf, Isabella C, Seneghini, Marco, Swiss HIV Cohort Study, Tarr, Philip E, Thorball, Christian W, Thurnheer, Maria Christine   +20 more
core   +4 more sources

Multi-tissue DNA methylation age predictor in mouse

Genome Biology, 2017
Background DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an underlying ageing process.
Thomas M. Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, BI Ageing Clock Team, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik   +7 more
doaj   +1 more source

Genetic insights on sleep schedules: this time, it's PERsonal. [PDF]

, 2012
The study of circadian rhythms is emerging as a fruitful opportunity for understanding cellular mechanisms that govern human physiology and behavior, fueled by evidence directly linking sleep disorders to genetic mutations affecting circadian molecular ...
Chong, SY Christin, Fu, Ying-Hui, Ptáček, Louis J   +2 more
core   +1 more source

A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics [PDF]

, 2019
Cellular, organ, and whole animal physiology show temporal variation predominantly featuring 24-h (circadian) periodicity. Time-course mRNA gene expression profiling in mouse liver showed two subsets of genes oscillating at the second (12-h) and third (8-
Biagini, Tommaso, Capocefalo, Daniele, Carbone, Annalucia, Castellana, Stefano, Genov, Nikolai, Mazza, Tommaso, Mazzoccoli, Gianluigi, Relógio, Angela, Rosati, Jessica, Scholkmann, Felix, Truglio, Mauro, Turco, Elisa Maria   +11 more
core   +1 more source

Effects of Maternal Vitamin D3 Supplementation on Offspring Epigenetic Clock of Gestational Age at Birth: A Post-hoc Analysis of a Randomized Controlled Trial

Epigenetics, 2020
Vitamin D could be beneficial for healthy ageing in humans. We previously found that vitamin D supplementation may slow down epigenetic ageing in young African American adults.
Li Chen, Carol L. Wagner, Yanbin Dong, Xiaoling Wang, Judith R. Shary, Ying Huang, Bruce W. Hollis, Haidong Zhu   +7 more
doaj   +1 more source

Age estimation in fishes using epigenetic clocks: Applications to fisheries management and conservation biology

Frontiers in Marine Science, 2023
The distribution of age classes is a key demographic parameter of populations and thus proper age estimation is crucial for fisheries management and for conservation biology.
Francesc Piferrer, Dafni Anastasiadi
doaj   +1 more source

Circadian clocks and breast cancer [PDF]

, 2016
Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V, Meng, Q-J, Streuli, CH, Williams, JL   +3 more
core   +2 more sources