Results 111 to 120 of about 1,306,054 (295)
Cancer epigenetics: from laboratory studies and clinical trials to precision medicine
Cell Death DiscoveryEpigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer. Defining the epigenetic defects associated with malignant tumors has become a focus of cancer research resulting in the gradual elucidation of cancer cell ...
Xinyang Yu +7 more
doaj +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Epigenetics in Drug Discovery: Achievements and Challenges
The epigenome comprises a range of covalent modifications of DNA and histone proteins that establish chromatin structure and function. These processes regulate gene expression without altering the DNA sequence and play an important role in regulating, e.g., brain function and associated behaviors.
Korda, Ziva +3 more
openaire +2 more sources
At the Flick of a Switch: Epigenetic Drugs
Chemistry & Biology, 2008 Leukemia and lymphoma, so-called “blood-based” cancers, share many firsts in the history of cancer research. They were the first cancers to be treated with radiation therapy (around 1900), the first to be clinically tested and treated with chemotherapy (nitrogen mustard in the 1940s), and, more recently, the first to be treated with a novel type of ...
openaire +2 more sources
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]
, 2015 BACKGROUND: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Deary, Ian J. +27 more
core +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Mechanisms underlying epigenetic gene silencing in maize [PDF]
Higher organisms can regulate gene expression through changes in epigenetic marks present on the genome. However, how this regulation takes place in organisms with highly repetitive/complex genomes is not well understood.
Schafer, David Gerald
core
, 2018 Duncan, Randall L.Barwe, SonaliPediatric acute myeloid leukemia (AML) is a type of blood cancer, accounting for 18% of childhood leukemia, in which mutated immature myeloid cells are present in the bone marrow.
Weber, Samantha J.
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source