Results 121 to 130 of about 1,306,054 (295)

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Systems level analysis of transgenerational spermatogenic inheritance predicts biomarkers and underlying pathways [PDF]

, 2009
Transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics has recently been discovered using a Drosophila systems model.
Abhay Sharma
core  

The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells

, 2015
[[abstract]]Epigenetic modifying enzymes have a crucial role in the pathogenesis of acute myeloid leukemia (AML). Methylation of lysine 9 on histone H3 by the methyltransferase G9a and SUV39H1 is associated with inhibition of tumor suppressor genes.
Lai, YS;Chen, JY;Tsai, HJ;Chen, TY;Hung, WC
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Investigation of hallmark epigenetic changes in a cancer stem cell model [PDF]

, 2010
Epigenetic control of gene expression is vital for normal development and differentiation of cells, and is also important in the development of disease.
Wild, L.
core  

Epigenetic therapy for breast cancer

, 2011
Both genetic and epigenetic alterations can control the progression of cancer. Genetic alterations are impossible to reverse, while epigenetic alterations are reversible.
Feng-Feng Cai, Xiao-Yan Zhong, Zhong, Xiao-Yan, Ming-Hong Wang, Wei-Jie Chen, Cai, Feng-Feng, Wang, Ming-Hong, Kohler, Corina, Zhang, Bei, Bei Zhang, Corina Kohler, Chen, Wei-Jie, Cai FF, Wang MH, Kohler C, Zhang B, Chen WJ, Zhong XY   +17 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Pharmacoepigenetics: from epigenetic regulation to personalized therapeutics

Frontiers in Pharmacology
Pharmacoepigenetics is an emerging field of precision medicine that examines how epigenetic modifications influence interindividual variability in drug response.
Ashley M. Nguyen, Tamer E. Fandy
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs

, 2015
Epigenetic silencing of tumor suppressor genes (TSGs) is considered a significant event in the progression of cancer. For example, EPB41L3, a potential biomarker in cervical cancer, is often silenced by cancer-specific promoter methylation.
Juul Overkamp (722689), Wisman, G. Bea A., van der Wijst, Monique G. P.; id_orcid, Ed Schuuring (73120), Martijn M. Terpstra (722693), Ate G.J. van der Zee (722697), Karsten, Gellert, Christian Huisman (722683), van der Zee, Ate G. J., Marianne G. Rots (435896), Schuuring, Ed; id_orcid, Gellert Karsten (722691), Huisman, Christian, Monique G.P. van der Wijst (722686), Terpstra, Martijn M., Klaas Kok (722695), Rots, Marianne G., Overkamp, Juul, Kok, Klaas, Falahi, Fahimeh, G. Bea A. Wisman (463870), Fahimeh Falahi (722688)   +21 more
core   +1 more source