Results 51 to 60 of about 2,264,000 (323)

Genome-wide analysis of epigenetic dynamics across human developmental stages and tissues

BMC Genomics, 2019
Background Epigenome is highly dynamic during the early stages of embryonic development. Epigenetic modifications provide the necessary regulation for lineage specification and enable the maintenance of cellular identity.
Xia Zhang, Yanglan Gan, Guobing Zou, Jihong Guan, Shuigeng Zhou   +4 more
doaj   +1 more source

The role of epigenetic modification in tumorigenesis and progression of pituitary adenomas: a systematic review of the literature.

PLoS ONE, 2013
BackgroundPituitary adenomas (PAs) are commonly occurring neoplasms with diverse endocrine and neurological effects. Although somatic gene mutations are uncommon in sporadic PAs, recent studies lend support to epigenetic modification as a potential cause
Matthew Pease, Chao Ling, William J Mack, Kai Wang, Gabriel Zada   +4 more
doaj   +1 more source

Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]

, 2013
© 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
A Dürr, A Filla, A Saveliev, A Wong, AH Koeppen, Annalisa Pastore, C Sandi, Chiranjeevi Sandi, D Globisch, E Grabczyk, E Greene, E Kim, GN Filippova, H Chen, H Holemon, H Stroud, I Castaldo, I De Biase, I De Biase, J Robertson, JL Bradley, JU Guo, KE Szulwach, M Mellén, M Pandolfo, M Tahiliani, Mark A. Pook, MC Haffner, MR Branco, MV Evans-Galea, N Chia, PK Chan, R Sharma, RD Wells, Ricardo Mouro Pinto, S Al-Mahdawi, S Kriaucionis, Sahar Al-Mahdawi, T Wang, V Campuzano, V Campuzano, Y Huang   +41 more
core   +7 more sources

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer. [PDF]

, 2020
Breast cancer is a common cancer that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast cancer incidence and flavonoid intake.
Anwar, Hina, Badgeley, Aja, Lakshmikuttyamma, Ashakumary, Lawrence, Katharine, Murphy, Paige, Selvakumar, Priyanga, Sharma, Urvashi   +6 more
core   +1 more source

Homeorhesis in Waddington's landscape by epigenetic feedback regulation

Physical Review Research, 2020
In multicellular organisms, cells differentiate into several distinct types during early development. Determination of each cellular state, along with the ratio of each cell type, as well as the developmental course during cell differentiation are highly
Yuuki Matsushita, Kunihiko Kaneko
doaj   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Epigenetic Modifications in Prostate Cancer

Epigenomics, 2014
Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics modifications are involved in the development and progression of this disease.
Ngollo, Marjolaine, Dagdemir, Aslihan, Karsli-Ceppioglu, Seher, Judes, Gaelle, Pajon, Amaury, Penault-Llorca, Frederique, Boiteux, Jean-Paul, Bignon, Yves-Jean, Guy, Laurent, Bernard-Gallon, Dominique J.   +9 more
openaire   +3 more sources

Bifurcation in epigenetics: implications in development, proliferation and diseases

, 2014
Cells often exhibit different and stable phenotypes from the same DNA sequence. Robustness and plasticity of such cellular states are controlled by diverse transcriptional and epigenetic mechanisms, among them the modification of biochemical marks on ...
Jost, Daniel
core   +1 more source

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Signal Transduction and Targeted Therapy, 2023
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease that affects an estimated 300 million people worldwide, but its pathogenesis is poorly understood.
Minlan Yuan, Biao Yang, Gerson Rothschild, J. John Mann, Larry D. Sanford, Xiangdong Tang, Canhua Huang, Chuang Wang, Wei Zhang   +8 more
doaj   +1 more source

Computational modeling to elucidate molecular mechanisms of epigenetic memory

, 2015
How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses?
Alsing, Andrews, Ang, Angel, Arnold, Bannister, Barth, Beisel, Benecke, Bhattacharya, Binder, Black, Buscaino, Bushey, Canzio, Cowieson, David-Rus, Dayarian, Deal, Dodd, Fonseca, Freddolino, Gaffney, Grauffel, Greer, Grewal, Grigoryev, Hanna, Hathaway, Henikoff, Herranz, Hodges, Jacobs, Korolev, Korolev, Kouzarides, Ku, Kulaeva, Lin, Margreitter, Margueron, Mendenhall, Muller, Papp, Pasque, Peinado, Piana, Potoyan, Prohaska, Raghavan, Rohlf, Sanbonmatsu, Sanli, Schwab, Schwammle, Sedighi, So, Sontag, Steffen, Takahashi, Teif, Thon, Wocjan, Xu, Yang, Yuan, Zee, Zhang, Zhang   +68 more
core   +1 more source