Results 31 to 40 of about 181,163 (261)
The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing
Cell Communication and Signaling, 2023 Background Epigenetic modifications of RNA significantly contribute to the regulatory processes in tumors and have, thus, received considerable attention.
Tongxuan Wen +5 more
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Epigenetic Modifications [PDF]
Circulation, 2011 The term epigenetics was first used to refer to the complex interactions between the genome and the environment that are involved in development and differentiation in higher organisms. Today, this term is used to refer to heritable alterations that are not due to changes in DNA sequence.
Diane E, Handy +2 more
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Epigenetic modification in diabetic kidney disease
Frontiers in Endocrinology, 2023 Diabetic kidney disease (DKD) is a common microangiopathy in diabetic patients and the main cause of death in diabetic patients. The main manifestations of DKD are proteinuria and decreased renal filtration capacity.
Zhe Liu +7 more
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Epigenetic modifications of histones in cancer [PDF]
Genome Biology, 2019 AbstractThe epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types of histone modifications and the biological processes with which they are involved. Specifically, we review the enzymatic machineries
Zibo Zhao, Ali Shilatifard
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Epigenetic Regulation in the Pathogenesis of Rheumatoid Arthritis
Frontiers in Immunology, 2022 Rheumatoid arthritis (RA) is an autoimmune disease. The etiology of RA remains undetermined and the pathogenesis is complex. There remains a paucity of ideal therapeutic drugs and treatment strategies. The epigenetic modifications affect and regulate the
Chao Yang +8 more
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Epigenetic Modifications in Prostate Cancer
Epigenomics, 2014 Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics modifications are involved in the development and progression of this disease.
Ngollo, Marjolaine +9 more
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Epigenetic modifications in prostate cancer [PDF]
International Journal of Urology, 2020 AbstractProstate cancer is a major cause of cancer‐related deaths among men worldwide. In addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have been elucidated. While aberrant deoxyribonucleic acid hypermethylation in promoter CpG islands inactivates crucial genes associated with deoxyribonucleic acid repair, cell ...
Masahiro, Sugiura +6 more
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Epigenetic modifications in cardiovascular disease [PDF]
Basic Research in Cardiology, 2012 Epigenetics represents a phenomenon of altered heritable phenotypic expression of genetic information occurring without changes in DNA sequence. Epigenetic modifications control embryonic development, differentiation and stem cell (re)programming. These modifications can be affected by exogenous stimuli (e.g., diabetic milieu, smoking) and oftentimes ...
Lorenzen, Johan M. +2 more
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Roles and therapeutic implications of m6A modification in cancer immunotherapy
Frontiers in Immunology, 2023 Recent studies have demonstrated that N6-methyladenosine (m6A), the most abundant, dynamic, and reversible epigenetic RNA modification in eukaryotes, is regulated by a series of enzymes, including methyltransferases (writers), demethylases (erasers), and
Juan Pan +7 more
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Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease
Neural Plasticity, 2019 Tau hyperphosphorylation is a typical pathological change in Alzheimer’s disease (AD) and is involved in the early onset and progression of AD. Epigenetic modification refers to heritable alterations in gene expression that are not caused by direct ...
Chao-Chao Yu +5 more
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