Results 41 to 50 of about 181,163 (261)
Genome-wide analysis of epigenetic dynamics across human developmental stages and tissues
BMC Genomics, 2019 Background Epigenome is highly dynamic during the early stages of embryonic development. Epigenetic modifications provide the necessary regulation for lineage specification and enable the maintenance of cellular identity.
Xia Zhang +4 more
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The Impact of Epigenetic Modifications in Myeloid Malignancies [PDF]
International Journal of Molecular Sciences, 2021 Myeloid malignancy is a broad term encapsulating myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Initial studies into genomic profiles of these diseases have shown 2000 somatic mutations prevalent across the spectrum of myeloid blood disorders.
Deirdra Venney +2 more
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PLoS ONE, 2013 BackgroundPituitary adenomas (PAs) are commonly occurring neoplasms with diverse endocrine and neurological effects. Although somatic gene mutations are uncommon in sporadic PAs, recent studies lend support to epigenetic modification as a potential cause
Matthew Pease +4 more
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Pulmonary Pathogen-Induced Epigenetic Modifications
Epigenomes, 2023 Epigenetics generally involves genetic control by factors other than our own DNA sequence. Recent research has focused on delineating the mechanisms of two major epigenetic phenomena: DNA methylation and histone modification. As epigenetics involves many
Dylan Wrede +3 more
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Homeorhesis in Waddington's landscape by epigenetic feedback regulation
Physical Review Research, 2020 In multicellular organisms, cells differentiate into several distinct types during early development. Determination of each cellular state, along with the ratio of each cell type, as well as the developmental course during cell differentiation are highly
Yuuki Matsushita, Kunihiko Kaneko
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Epigenetic Modification of Genetic Algorithm [PDF]
, 2020 The article presents a new operation in the genetic algorithm. This operation mimics the epigenetic process of cytosine methylation. The Epigenetic processes have a huge impact on the functioning of living organisms, but have not yet been reflected in the operations of genetic algorithms. In a study on the evaluation of the operation mimics epigenetics
Kornel Chrominski +2 more
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Signal Transduction and Targeted Therapy, 2023 Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease that affects an estimated 300 million people worldwide, but its pathogenesis is poorly understood.
Minlan Yuan +8 more
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Epigenetic Modifications in Essential Hypertension [PDF]
International Journal of Molecular Sciences, 2016 Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world’s leading public health problems. Furthermore, there is increasing evidence that epigenetic modifications are as important as genetic predisposition in ...
Ingrid Wise, Fadi Charchar
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Genetic variation stimulated by epigenetic modification. [PDF]
PLoS ONE, 2008 Homologous recombination is essential for maintaining genomic integrity. A common repair mechanism, it uses a homologous or homeologous donor as a template for repair of a damaged target gene.
W Jason Cummings +2 more
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Traditional Chinese Medicine: A Class of Potentially Reliable Epigenetic Drugs
Frontiers in Pharmacology, 2022 Epigenetic modification, especially DNA methylation, plays a nonnegligible role in the occurrence and development of tumors. Increasing studies are indicating that traditional Chinese medicine (TCM) plays a considerable anti-tumor role by regulating the ...
Daoqi Zhu, Aiwu Li, Ying Lv, Qin Fan
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