Results 51 to 60 of about 181,163 (261)

Epigenetic Modifications and Diabetic Retinopathy [PDF]

BioMed Research International, 2013
Diabetic retinopathy remains one of the most debilitating chronic complications, but despite extensive research in the field, the exact mechanism(s) responsible for how retina is damaged in diabetes remains ambiguous. Many metabolic pathways have been implicated in its development, and genes associated with these pathways are altered.
Kowluru, Renu A., Santos, Julia M., Mishra, Manish   +2 more
openaire   +2 more sources

The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

Frontiers in Cardiovascular Medicine, 2022
Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the ...
Kun Zhao, Yukang Mao, Yansong Li, Chuanxi Yang, Chuanxi Yang, Kai Wang, Jing Zhang   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Epigenetic modifications in rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2008
Over the last decades, genetic factors for rheumatoid diseases like the HLA haplotypes have been studied extensively. However, during the past years of research, it has become more and more evident that the influence of epigenetic processes on the development of rheumatic diseases is probably as strong as the genetic background of a patient. Epigenetic
Strietholt, Simon, Maurer, Britta, Peters, Marvin A, Pap, Thomas, Gay, Steffen   +4 more
openaire   +3 more sources

Epigenetic regulation of angiogenesis and its therapeutics

Genomics & Informatics
Angiogenesis, the formation of new blood vessels from preexisting ones, is essential for normal development, wound healing, and tissue repair. However, dysregulated angiogenesis is implicated in various pathological conditions, including cancer, diabetic
Dong Kyu Choi
doaj   +1 more source

Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus. [PDF]

PLoS ONE, 2012
Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises the possibility that altered chromatin modification dynamics might contribute to age-dependent cognitive decline. Here we show that the coordinated orchestration
James F Castellano, Bonnie R Fletcher, Bennett Kelley-Bell, David H Kim, Michela Gallagher, Peter R Rapp   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Potential epigenetic molecular regulatory networks in ocular neovascularization

Frontiers in Genetics, 2022
Neovascularization is one of the many manifestations of ocular diseases, including corneal injury and vascular diseases of the retina and choroid. Although anti-VEGF drugs have been used to effectively treat neovascularization, long-term use of anti ...
Qiang Hu, Xue Zhang, Minghao Sun, Bo jiang, Zhongyu Zhang, Dawei Sun   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source