Results 61 to 70 of about 2,264,000 (323)

Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]

, 2019
Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate, Le Roch, Karine G, Lu, Yang Y, Noble, William Stafford, Read, David F   +4 more
core   +2 more sources

Traditional Chinese Medicine: A Class of Potentially Reliable Epigenetic Drugs

Frontiers in Pharmacology, 2022
Epigenetic modification, especially DNA methylation, plays a nonnegligible role in the occurrence and development of tumors. Increasing studies are indicating that traditional Chinese medicine (TCM) plays a considerable anti-tumor role by regulating the ...
Daoqi Zhu, Aiwu Li, Ying Lv, Qin Fan
doaj   +1 more source

Epigenetic Modifications and Diabetic Retinopathy [PDF]

BioMed Research International, 2013
Diabetic retinopathy remains one of the most debilitating chronic complications, but despite extensive research in the field, the exact mechanism(s) responsible for how retina is damaged in diabetes remains ambiguous. Many metabolic pathways have been implicated in its development, and genes associated with these pathways are altered.
Kowluru, Renu A., Santos, Julia M., Mishra, Manish   +2 more
openaire   +2 more sources

Genetic variation stimulated by epigenetic modification. [PDF]

PLoS ONE, 2008
Homologous recombination is essential for maintaining genomic integrity. A common repair mechanism, it uses a homologous or homeologous donor as a template for repair of a damaged target gene.
W Jason Cummings, David W Bednarski, Nancy Maizels   +2 more
doaj   +1 more source

The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

Frontiers in Cardiovascular Medicine, 2022
Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the ...
Kun Zhao, Yukang Mao, Yansong Li, Chuanxi Yang, Chuanxi Yang, Kai Wang, Jing Zhang   +6 more
doaj   +1 more source

The physics of epigenetics

, 2016
In higher organisms, all cells share the same genome, but every cell expresses only a limited and specific set of genes that defines the cell type. During cell division, not only the genome, but also the cell type is inherited by the daughter cells. This
Barbi, Maria, Caré, Bertrand R., Cortini, Ruggero, Lavelle, Christophe, Lesne, Annick, Mozziconacci, Julien, Victor, Jean-Marc   +6 more
core   +3 more sources

Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus. [PDF]

PLoS ONE, 2012
Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises the possibility that altered chromatin modification dynamics might contribute to age-dependent cognitive decline. Here we show that the coordinated orchestration
James F Castellano, Bonnie R Fletcher, Bennett Kelley-Bell, David H Kim, Michela Gallagher, Peter R Rapp   +5 more
doaj   +1 more source

Epigenetic modification of cytosines fine tunes the stability of i-motif DNA

Nucleic Acids Research, 2019
i-Motifs are widely used in nanotechnology, play a part in gene regulation and have been detected in human nuclei. As these structures are composed of cytosine, they are potential sites for epigenetic modification.
Elisé P. Wright, Mahmoud A S Abdelhamid, Michelle O Ehiabor, Melanie Grigg, Kelly L Irving, N. Smith, Z. Waller   +6 more
semanticscholar   +1 more source

Epigenetic Modifications in Essential Hypertension [PDF]

International Journal of Molecular Sciences, 2016
Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world’s leading public health problems. Furthermore, there is increasing evidence that epigenetic modifications are as important as genetic predisposition in ...
Ingrid Wise, Fadi Charchar
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source