Results 11 to 20 of about 307,044 (299)
Metabolic Regulation of Epigenetics [PDF]
Cell Metabolism, 2012 How cells sense and respond to environmental cues remains a central question of biological research. Recent evidence suggests that DNA transcription is regulated by chromatin organization. However, the mechanism for relaying the cytoplasmic signaling to chromatin remodeling remains incompletely understood.
Lu, Chao, Thompson, Craig B.
openaire +2 more sources
Epigenetic Regulation and Measurement of Epigenetic Changes [PDF]
Biological Research For Nursing, 2012 Epigenetic mechanisms provide an adaptive layer of control in the regulation of gene expression that enables an organism to adjust to a changing environment. Epigenetic regulation increases the functional complexity of deoxyribonucleic acid (DNA) by altering chromatin structure, nuclear organization, and transcript stability.
Stephens, Kimberly E +4 more
openaire +4 more sources
Epigenetic regulation of myogenesis [PDF]
Epigenetics, 2009 Adult skeletal muscle provides a unique paradigm for studying stem to differentiated cell transitions. In response to environmental stress, quiescent muscle stem cells (satellite cells) are activated and proliferative, at which stage they can either differentiate and fuse to form new muscle fibers or alternatively self-renew and maintain the muscle ...
Eusebio, Perdiguero +3 more
openaire +2 more sources
Sirtuins in Epigenetic Regulation [PDF]
Chemical Reviews, 2015 1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information regulator 2 (SIR2) protein, one of four proteins (SIR1–4) required for silencing the mating-type information loci in yeast.1 SIR2–4, but not SIR1, are also required for gene silencing at telomeres.2 SIR2 also mediates gene silencing at the rDNA (rDNA) loci ...
Jing, Hui, Lin, Hening
openaire +2 more sources
Epigenetic regulation of hematopoiesis [PDF]
International Journal of Hematology, 2012 Epigenetic regulation is required not only for development, but also for tissue homeostasis, which is maintained via the self-renewal and differentiation of somatic stem cells. Accumulating evidence suggests that epigenetic regulators play critical roles in the maintenance of both self-renewing hematopoietic stem cells and leukemic stem cells.
Goro, Sashida, Atsushi, Iwama
openaire +2 more sources
Epigenetic Regulation of Cellular Senescence [PDF]
Cells, 2022 Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease. How a cell transitions to a senescent state is multifactorial and often requires transcriptional regulation of multiple genes.
Jack Crouch +4 more
openaire +3 more sources
Epigenetic Regulation of Adipokines [PDF]
International Journal of Molecular Sciences, 2017 Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-specific hormones that can regulate whole body energy metabolism. Epigenetic regulation of gene expression is a mechanism by which cells can alter gene expression through the modifications of DNA and histones.
Pham, Tho X., Lee, Ji-Young
openaire +2 more sources
Epigenetic Regulation in Plants [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 The study of epigenetics in plants has a long and rich history, from initial descriptions of non-Mendelian gene behaviors to seminal discoveries of chromatin-modifying proteins and RNAs that mediate gene silencing in most eukaryotes, including humans. Genetic screens in the model plant Arabidopsis have been particularly rewarding, identifying more than
Craig S, Pikaard +1 more
openaire +2 more sources
Clinical analysis of 11 cases of nocardiosis
Open Medicine, 2021 Nocardiosis is a rare, life-threatening, opportunistic, and suppurative infection. Its clinical manifestation lacks specificity, which makes early diagnosis difficult.
Li Yiqing +7 more
doaj +1 more source
Epigenetic regulation in medulloblastoma [PDF]
Molecular and Cellular Neuroscience, 2018 Medulloblastoma is the most common malignant childhood brain tumor. The heterogeneous tumors are classified into four subgroups based on transcription profiles. Recent developments in genome-wide sequencing techniques have rapidly advanced the understanding of these tumors.
Jiaqing, Yi, Jiang, Wu
openaire +2 more sources