Results 121 to 130 of about 93,647 (322)
EpiAlign: an alignment-based bioinformatic tool for comparing chromatin state sequences. [PDF]
, 2019 The availability of genome-wide epigenomic datasets enables in-depth studies of epigenetic modifications and their relationships with chromatin structures and gene expression.
Ge, Xinzhou +5 more
core +2 more sources
Homo sapiens, industrialisation and the environmental mismatch hypothesis
Biological Reviews, EarlyView.ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley +1 more source
Transcription factor network dynamics during the commitment to oncogene-induced senescence
Frontiers in Epigenetics and EpigenomicsAberrant oncogenic signaling causes cells to transition into oncogene-induced senescence (OIS) to limit uncontrolled proliferation. Despite being a potent tumor suppressor mechanism, OIS is an unstable cell state susceptible to reprogramming that can ...
Themistoklis Vasilopoulos +1 more
doaj +1 more source
Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. [PDF]
, 2018 Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the ...
McKinsey, Timothy A +2 more
core
Integration of epigenetics into ecotoxicology: insights and fundamental research needs
Biological Reviews, EarlyView.ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto +3 more
wiley +1 more source
From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma
Cancer Science, EarlyView.ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley +1 more source
Re-searching nasopharyngeal carcinoma
Guangxi Yike Daxue xuebaoNasopharyngeal carcinoma (NPC) has been a focus of medical research for more than 100 years, with significant interest emerging over the last 58 years following the identification of the link between the disease and Epstein-Barr virus (EBV) infection ...
Ingemar Ernberg +2 more
doaj +1 more source
Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents
Cell Proliferation, EarlyView.Our study (1) represented a first systematic analysis of species‐specific adaptation in the DNA binding pattern of transcription factor; (2) represented a first study of cis‐regulation between two reproductively isolated species by using a novel allodiploid system; (3) demonstrated a higher conservation of transcriptional output than that of DNA ...
Weizheng Liang +13 more
wiley +1 more source
EpigenomesAn understanding of the molecular mechanism whereby an environmental chemical causes a disease is important for the purposes of future applications. In this study, a multiomics workflow was designed to combine several publicly available datasets in order
Majid Nikpay
doaj +1 more source