Results 121 to 130 of about 21,621 (295)

Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy

Marine Drugs, 2020
Sessile organisms such as seaweeds, corals, and sponges continuously adapt to both abiotic and biotic components of the ecosystem. This extremely complex and dynamic process often results in different forms of competition to ensure the maintenance of an ...
Mariarosaria Conte, Elisabetta Fontana, Angela Nebbioso, Lucia Altucci   +3 more
doaj   +1 more source

Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)

Journal of Clinical Laboratory Analysis, EarlyView.
(A) Post hoc pairwise comparisons between the four studied groups regarding the log2 of serum fold change of CircFUNDC1. There were significant differences between CRC, UC, or CD and controls. p values (Controls vs. UC = < 0.001, Controls vs. CD = < 0.001, Controls vs. CRC = < 0.001, UC vs. CD = 1.000, UC vs. CRC = 0.194, CD vs. CRC = 0.255).
Marwa A. Ali, Olfat G. Shaker, Eman M. Ezzat, Abeer A. Khalefa, Naglaa A. Ahmed, Raghda Yahia Abu El‐Ela, Amal A. Ibrahim Amin, Fatma Abdel Hamid Mohamed, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Saad Zaghloul Ahmed, Marwa N. AbdelHafez, Abdulrhman Khaled Al Abdulqader, Reham Fares   +12 more
wiley   +1 more source

Multiomics Reveal Associations Between CpG Methylation, Histone Modifications and Transcription in a Species That has Lost DNMT3, the Colorado Potato Beetle

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger, Elisa Israel, Jan Engelhardt, Agata I. Kalita, Claudia I. Keller Valsecchi, Joachim Kurtz, Sonja J. Prohaska   +6 more
wiley   +1 more source

A Developmental Network Theory of Gynandromorphs, Sexual Dimorphism and Species Formation [PDF]

arXiv, 2012
Gynandromorphs are creatures where at least two different body sections are a different sex. Bilateral gynandromorphs are half male and half female. Here we develop a theory of gynandromorph ontogeny based on developmental control networks. The theory explains the embryogenesis of all known variations of gynandromorphs found in multicellular organisms.
arxiv  

Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion

Cell, 2023
Xushen Xiong, Benjamin T. James, Carles A. Boix, Yongjin P. Park, K. Galani, Matheus B. Victor, Na Sun, Lei Hou, Li-Lun Ho, Julio Mantero, Áine Ní Scannail, V. Dileep, Weixiu Dong, Hansruedi Mathys, David A. Bennett, Li-Huei Tsai, M. Kellis   +16 more
semanticscholar   +1 more source

Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient ...
Ahana Maitra, Morena Miciaccia, Manuela Mandorino, Domenico Armenise, Olga Maria Baldelli, Savina Ferorelli, Ludmila Papusha, Alexander Druy, Maria Grazia Perrone, Antonio Scilimati   +9 more
wiley   +1 more source

Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse

Mobile DNA
Background Gene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis regulatory elements.
Beverly Ann G. Boyboy, Kenji Ichiyanagi
doaj   +1 more source

An Efficient Sufficient Dimension Reduction Method for Identifying Genetic Variants of Clinical Significance [PDF]

arXiv, 2013
Fast and cheaper next generation sequencing technologies will generate unprecedentedly massive and highly-dimensional genomic and epigenomic variation data. In the near future, a routine part of medical record will include the sequenced genomes. A fundamental question is how to efficiently extract genomic and epigenomic variants of clinical utility ...
arxiv  

Folate‐Associated DNA Methylation and Chemotherapy‐Induced Toxicities in Patients With Colorectal Cancer

Molecular Nutrition &Food Research, EarlyView.
Over half of patients with colorectal cancer experience severe chemotherapy‐induced side effects. The B‐vitamin folate may play a role in these side effects, potentially by altering DNA methylation, a mechanism of gene regulation. Our comprehensive literature search identified studies investigating DNA methylation associated with folate status/intake ...
Nienke R. K. Zwart, Dieuwertje E. Kok, Sajini N. H. Ariyaratne, Jill A. McKay   +3 more
wiley   +1 more source

ERRATUM: Acknowledgments Correction. Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer [PDF]

Genomics & Informatics, 2015
Jong-Lyul Park, Mirang Kim, Kyu-Sang Song, Seon-Young Kim, Yong Sung Kim   +4 more
doaj   +1 more source