Results 131 to 140 of about 87,804 (313)
Human Molecular Genetics, 2002 Research in cancer epigenomics is driven by the development of novel technologies and the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades, the search for cancer genes has focused on genetic defects that were used as tags for identification of these genes.
openaire +2 more sources
Intralitter Variability Influences the Developmental Impact of Valproic Acid Exposure in CD‐1 Mice
Journal of Applied Toxicology, EarlyView.ABSTRACT Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug that causes teratogenic effects, including neural tube defects (NTDs), when taken during pregnancy. Although animal models are widely used to study VPA teratogenicity, most rely on litter means, which overlook variability within the litter.
Lauren T. L. Brown +3 more
wiley +1 more source
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger +6 more
wiley +1 more source
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy
Medicinal Research Reviews, EarlyView.ABSTRACT Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient ...
Ahana Maitra +9 more
wiley +1 more source
The Dynamic Epigenome and its Implications in Toxicology [PDF]
, 2007 Moshe Szyf
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Molecular Nutrition &Food Research, EarlyView.Folic acid (FA), a methyl donor in one‐carbon (1C) metabolism, is essential for gene methylation and expression and reported to reduce insulin resistance (IR). However, whether reduced IR is mediated by insulin receptor (InsR) gene methylation is unknown.
Eva Kranenburg +6 more
wiley +1 more source
PROTEOMICS, EarlyView.ABSTRACT Embryo development involves fertilization of a mature ovum, which, after sequential cell divisions (2‐,4‐8‐cells and morula), undergoes differentiation into implantation competent blastocyst. The blastocyst comprises of inner cell mass surrounded by an outer layer of cells called the trophoblast (TSblast) that, upon attachment to the ...
Alin Rai +5 more
wiley +1 more source
Are physiological oscillations physiological?
The Journal of Physiology, EarlyView., 2023 Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley +1 more source
Moving AHEAD with an international human epigenome project [PDF]
, 2008 Peter A. Jones +33 more
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