Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer [PDF]
Hey Min Lee +15 more
openalex +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
DNA methylation meets lineage tracing: History, recent progress, and future directions
Quantitative Biology, Volume 14, Issue 1, March 2026.Abstract Lineage tracing techniques have been developed rapidly in the past decades by employing new genetic engineering tools. However, due to their invasive nature, these are difficult to apply to humans. Although endogenous DNA mutations can be used for in vivo lineage tracing in humans, their extremely low mutation rate presents substantial ...
Ruijiang Fu +2 more
wiley +1 more source
The cancer epigenome—components and functional correlates [PDF]
, 2006 Angela H. Ting +2 more
openalex +1 more source
Single‐cell mitochondrial lineage tracing: Opportunities and challenges
Quantitative Biology, Volume 14, Issue 1, March 2026.Abstract Lineage tracing using endogenous mitochondrial DNA (mtDNA) variants holds great promise for reconstructing the lineage histories of individual cells, with broad applications in oncology, developmental biology, and regenerative medicine.
Siqi Li, Kun Wang, Xin Wang, Zheng Hu
wiley +1 more source
Predicting the effect of CRISPR-Cas9-based epigenome editing. [PDF]
ElifeBatra SS +6 more
europepmc +1 more source
The epigenomic landscape of transposable elements across normal human development and anatomy [PDF]
, 2019 Choudhary, Mayank N.K. +3 more
core +1 more source
Molecular polymorphisms that underlie trait variation in crops: Lessons learned from soybean
The Plant Genome, Volume 19, Issue 1, March 2026.Abstract Genetic variation within a germplasm is important in crop improvement, providing a foundation for breeders to develop new varieties. Traits of agronomic and economic importance are often mapped to identify the genetic basis of observed phenotypes, oftentimes using quantitative trait locus (QTL) analysis.
Mary Jane C. Espina +2 more
wiley +1 more source
Epigenetic Editing in Neurological and Neuropsychiatric Disorders: Pioneering Next-Gen Therapeutics for Precision Gene Control. [PDF]
Mol NeurobiolMarei HE.
europepmc +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.ABSTRACT Background Adverse childhood experiences (ACEs) are stressful or traumatic events prior to age 18 that are known to have a lasting impact on individuals’ health and well‐being. There is a gap in understanding the relationship between ACEs and Other Life Stressors and health status for adults with sickle cell disease (SCD).
Marsha Treadwell +8 more
wiley +1 more source