SIGMA2: A system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes [PDF]
, 2008 Raj Chari +8 more
openalex +1 more source
Journal of Neuroendocrinology, EarlyView.Abstract Maternal obesity associates with an increased risk of offspring neurodevelopmental disorders. Although the underlying mechanism(s) remain unclear, evidence suggests a role for altered DNA methylation. We utilized a murine model of diet‐induced obesity to investigate the impact of maternal obesity on the offspring brain transcriptome and DNA ...
Kahyee Hor +5 more
wiley +1 more source
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping [PDF]
, 2008 Christoph Bock +3 more
openalex +1 more source
Daily rhythm in DNA methylation and the effect of total sleep deprivation
Journal of Sleep Research, EarlyView.Summary Numerous hormones and genes exhibit diurnal 24‐hr rhythms that can also be affected by sleep deprivation. Here we studied diurnal rhythms in DNA methylation under a 24‐hr sleep/wake cycle and a subsequent 29 hr of continual wakefulness (1 night of sleep deprivation).
Antti‐Jussi Ämmälä +9 more
wiley +1 more source
Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2 [PDF]
, 2008 Jennifer Anderton +6 more
openalex +1 more source
Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque
Molecular Ecology, EarlyView.ABSTRACT Genetic variation that impacts gene regulation, rather than protein function, can have strong effects on trait variation both within and between species. Epigenetic mechanisms, such as DNA methylation, are often an important intermediate link between genotype and phenotype, yet genetic effects on DNA methylation remain understudied in natural ...
Christina E. Costa +12 more
wiley +1 more source
Mining the Epigenome for Methylated Genes in Lung Cancer [PDF]
, 2008 Mathewos Tessema, Steven A. Belinsky
openalex +1 more source
Exploring the untapped potential of single‐cell and spatial omics in plant biology
New Phytologist, EarlyView.Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The field of plant biology has widely adopted single‐cell transcriptome and chromatin accessibility profiling and spatial transcriptomics, which extend ...
Tatsuya Nobori
wiley +1 more source
CRISPR-based epigenome editing of cytokine receptors for the promotion of cell survival and tissue deposition in inflammatory environments [PDF]
, 2017 Bowles, Robby D +8 more
core +2 more sources
Predicting the Future: Parental Progeny Investment in Response to Environmental Stress Cues [PDF]
, 2019 Environmental stressors can severely limit the ability of an organism to reproduce as lifespan is decreased and resources are shifted away from reproduction to survival.
Gulyas, Leah, Powell, Jennifer R.
core +1 more source