Results 171 to 180 of about 87,804 (313)

Integration of omics data in the diagnosis and therapy of glioblastoma

Brain Pathology, EarlyView.
Integration of omics data in the diagnosis and therapy of glioblastoma. Abstract Since the 2016 update of the WHO Classification of Tumors of the Central Nervous System, omics data have been officially integrated into the diagnostic process for glioblastoma, the most prevalent and aggressive primary malignant brain tumor in adults.
Constantin Möller, Melanie Schoof, Keith L. Ligon, Ulrich Schüller   +3 more
wiley   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

RNA as the substrate for epigenome‐environment interactions [PDF]

, 2010
John S. Mattick
openalex   +1 more source

Reversibility of sex changes in the plant kingdom: more important than we thought?

Biological Reviews, EarlyView.
ABSTRACT Compared to animals, plants show a wide range of reproductive strategies with different degrees of sex separation (e.g. dioecy, monoecy, hermaphroditism). While sex expression was previously thought to be genetically determined and fixed in plants, accumulating evidence suggests that sex expression can change reversibly even within one ...
Iris Sammarco, Eliška Krtilová, Marek Slovák, Clément Lafon Placette   +3 more
wiley   +1 more source

Quantitative mass spectrometry reveals the epigenome as a target of arsenic [PDF]

, 2010
Feixia Chu, Xuefeng Ren, Amanda E. Chasse, Taylor Hickman, Luoping Zhang, Jessica Yuh, Martyn T. Smith, Alma L. Burlingame   +7 more
openalex   +1 more source

CircCDYL Association With hnRNPL Modulates CDYL Isoform Switching in Breast Cancer Cells

Cancer Science, EarlyView.
We investigated the synergic role of the circRNA circCDYL and the splicing factor hnRNPL in modulating alternative splicing and isoform switch in breast cancer cells, with a focus on circCDYL and hnRNPL‐mediated isoform switch events involving the CDYL gene.
Serena Bernardi, Giorgia Risso, Lorenzo Franchitti, Alessandro Camandona, Jean‐Marie Robbin, Isabella Tarulli, Giulio Ferrero, Lucia Coscujuela Tarrero, Valentina Miano, Michele De Bortoli, Ymera Pignochino, Santina Cutrupi   +11 more
wiley   +1 more source

Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins [PDF]

, 2011
Hiroko Sugawara, Kazuya Iwamoto, Miki Bundo, Junko Ueda, T. Miyauchi, Atsuko Komori, An‐a Kazuno, Naoki Adati, Ichiro Kusumi, Yozo Okazaki, Jun Ishigooka, Takashi Kojima, Tadafumi Kato   +12 more
openalex   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression [PDF]

, 2011
Melissa Suter, Jun Ma, A S Harris, Lauren Patterson, Kathleen Brown, Cynthia Shope, Lori Showalter, Adi Abramovici, Kjersti Aagaard‐Tillery   +8 more
openalex   +1 more source

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

Cell Proliferation, EarlyView.
Our study (1) represented a first systematic analysis of species‐specific adaptation in the DNA binding pattern of transcription factor; (2) represented a first study of cis‐regulation between two reproductively isolated species by using a novel allodiploid system; (3) demonstrated a higher conservation of transcriptional output than that of DNA ...
Weizheng Liang, Guipeng Li, Yukai Wang, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui, Wei Chen   +13 more
wiley   +1 more source