Results 61 to 70 of about 87,804 (313)

Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA). [PDF]

, 2018
BackgroundEpigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.ObjectiveWe sought to examine the associations of residential proximity to roadways at birth and ...
Agha, Golareh, Baccarelli, Andrea A, Cardenas, Andres, Coull, Brent A, de Kluizenaar, Yvonne, DeMeo, Dawn L, den Dekker, Martijn, Duijts, Liesbeth, Felix, Janine F, Gibson, Heike, Gilman, Matthew W, Gold, Diane R, Harris, Maria H, Hivert, Marie-France, Jaddoe, Vincent W, Litonjua, Augusto A, Oken, Emily, Peng, Cheng, Rifas-Shiman, Sheryl L, Sagiv, Sharon K, Schwartz, Joel   +20 more
core   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

4β-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells

Scientific Reports, 2017
Alternative splicing is a mechanism for increasing protein diversity from a limited number of genes. Studies have demonstrated that aberrant regulation in the alternative splicing of apoptotic gene transcripts may contribute to the development of cancer.
Chien-Chin Lee, Wen-Hsin Chang, Ya-Sian Chang, Ting-Yuan Liu, Yu-Chia Chen, Yang-Chang Wu, Jan-Gowth Chang   +6 more
doaj   +1 more source

Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review

Metabolites, 2023
Maternal mineral nutrition during the critical phases of fetal development may leave lifetime impacts on the productivity of an individual. Most research within the developmental origins of the health and disease (DOHaD) field is focused on the role of ...
Muhammad Anas, Wellison J. S. Diniz, Ana Clara B. Menezes, Lawrence P. Reynolds, Joel S. Caton, Carl R. Dahlen, Alison K. Ward   +6 more
doaj   +1 more source

EpiAlign: an alignment-based bioinformatic tool for comparing chromatin state sequences. [PDF]

, 2019
The availability of genome-wide epigenomic datasets enables in-depth studies of epigenetic modifications and their relationships with chromatin structures and gene expression.
Ge, Xinzhou, Kwon, Soo Bin, Li, Jingyi Jessica, Li, Wei Vivian, Xie, Lingjue, Zhang, Haowen   +5 more
core   +2 more sources

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

Integration of Bioengineered Tools in Assisted Reproductive Technologies

Advanced Healthcare Materials, EarlyView.
A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak, Edith Coonen, Ron van Golde, Erik Vrij   +3 more
wiley   +1 more source

chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome [PDF]

, 2013
Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question.
Boulesteix, Celniker, David Rossell, Dunham, Ernst, Ernst, Ernst, Fernando Azorín, Filion, Gan, Gentleman, Gerstein, Joan Font-Burgada, Karnik, Kharchenko, Lange, Lee, Lin, Liu, Lloret-Llinares, Lloret-Llinares, Miclaus, Motsinger, Musselman, Oscar Reina, Pedersen, Pérez-Lluch, Roudier, Roy, Smoot, Steiner, Torgerson, van Bemmel, van de Wiel   +33 more
core   +2 more sources

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Nutrición e Inflamación: mediadores epigenéticos

Revista Española de Nutrición Humana y Dietética, 2020
III Congreso de Alimentación, Nutrición y Dietética. Combinar la nutrición comunitaria y personalizada: nuevos retos.
Lidia Daimiel, Víctor Micó, Laura Díez, Paloma Ruiz, José María Ordovás   +4 more
doaj   +2 more sources