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New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine [PDF]
DiagnosticsFollowing the application of epigenetic and epigenomics research into tumor diseases, cardiovascular disease, diabetes, hereditary diseases, and rare diseases, in vitro diagnostics (IVD) epigenetic and epigenomics are increasingly employed for those ...
Pengtao Song, Biaoru Li
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EpiCHAOS: a metric to quantify epigenomic heterogeneity in single-cell data [PDF]
Genome BiologyEpigenetic heterogeneity is a fundamental property of biological systems and is recognized as a potential driver of tumor plasticity and therapy resistance.
Katherine Kelly +4 more
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BMC Gastroenterology, 2021 Background Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis, primarily due to failed early detection. HCC screening is recommended among individuals with cirrhosis using biannual abdominal ultrasound, for earlier ...
Jörn Lewin +13 more
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Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle? [PDF]
, 2013 DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely required for the expression of many viral genes.
Sinclair, Alison J
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Titration-based normalization of antibody amount improves consistency of ChIP-seq experiments
BMC Genomics, 2023 Chromatin immunoprecipitation (ChIP) is an antibody-based approach that is frequently utilized in chromatin biology and epigenetics. The challenge in experimental variability by unpredictable nature of usable input amounts from samples and undefined ...
Ariel Caride +11 more
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Scientific Reports, 2023 Menstruation is a natural phenomenon for every female, starting from adolescents to menopausal age. Any disturbances in menstrual patterns can eventually affect one’s physical as well as psychological health which in turn hamper the quality of life of ...
Shrinjana Dhar +2 more
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Cell Death and Disease, 2023 Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and cargo of their ...
Ilaria Petraroia +10 more
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Brazilian Archives of Biology and Technology, 2022 DNA methylation and Histone are the main constituents to oversee the stable maintenance of cellular phenotypes. Any abnormalities in these components could cause cancer development and, therefore, must be potentially diagnostic.
Wakar Ahmad +3 more
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RNA N6-methyladenosine methylation and skin diseases
Autoimmunity, 2023 Skin diseases are global health issues caused by multiple pathogenic factors, in which epigenetics plays an invaluable role. Post-transcriptional RNA modifications are important epigenetic mechanism that regulate gene expression at the genome-wide level.
Yaqin Yu +6 more
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BMC Research Notes, 2019 Objective DNA methylation analysis via real-time PCR or other analytical techniques requires purified bisulfite converted DNA. We report on an automated high throughput solution for DNA extraction, bisulfite-conversion, and purification of 96 samples ...
Sebastian Rausch +4 more
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