The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
Epigenetic investigation into <i>NR3C1</i> exon 1F and <i>HSD11B2</i>: associations with neurodevelopment and oral feeding skills in preterm infants. [PDF]
Griffith T +8 more
europepmc +1 more source
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley +1 more source
Comment on Komé et al. One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes in Multidose Pens. [PDF]
Tejera-Pérez C.
europepmc +1 more source
SwarmGenomics: A Unified Pipeline for Individual‐Based Whole‐Genome Analyses
ABSTRACT Advances in sequencing technologies have made whole‐genome data widely accessible, enabling research in population genetics, evolutionary biology, and conservation. However, analysing whole‐genome sequencing (WGS) data remains challenging, often requiring multiple specialised tools and substantial bioinformatics expertise.
Aure Kylmänen +5 more
wiley +1 more source
New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine. [PDF]
Song P, Li B.
europepmc +1 more source
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Understanding and Advancing Wound Healing in the Era of Multi-Omic Technology. [PDF]
Jing SL +5 more
europepmc +1 more source
Integration of epigenetics into ecotoxicology: insights and fundamental research needs
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto +3 more
wiley +1 more source
Machine learning tools for deciphering the regulatory logic of enhancers in health and disease. [PDF]
Foutadakis S +5 more
europepmc +1 more source

