Results 131 to 140 of about 64,265 (410)
Epigenome dysregulation in cholangiocarcinoma [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018 Epigenomics is a fast-evolving field of research that has lately attracted considerable interest, mainly due to the reversibility of epigenetic marks. Clinically, among solid tumors, the field is still limited. In cholangiocarcinoma (CCA) it is well known that the epigenetic landscape is deregulated both during carcinogenesis and disease progression as
O'Rourke, Colm J +3 more
openaire +4 more sources
A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
Advanced Science, EarlyView.The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye +21 more
wiley +1 more source
Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity [PDF]
arXiv, 2015 Network analysis is a powerful way of modeling chromatin interactions. Assortativity is a network property used in social sciences to identify factors affecting how people establish social ties. We propose a new approach, using chromatin assortativity to integrate the epigenomic landscape of a specific cell type with its chromatin interaction network ...
arxiv
Current Neuropharmacology, 2020 Background: Alzheimer’s (AD) and Parkinson’s diseases (PD) show deposits of improperly folded modified proteins. Protein expression mechanisms are involved since the early stages.
S. Mayo +4 more
semanticscholar +1 more source
Epigenomics: Mapping the Methylome [PDF]
Cell Cycle, 2005 DNA methylation is integral to normal development and disease processes. However, the genomic distribution of methylated sequences--the methylome--is poorly understood. We have recently developed a platform technology for rapid assessment of methylation status throughout the human genome in a high-resolution, high-throughput manner. This is achieved by
Wilson, Ian M. +7 more
openaire +3 more sources
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
ASB1 differential methylation in ischaemic cardiomyopathy. Relationship with left ventricular performance in end stage heart failure patients [PDF]
arXiv, 2017 Aims: Ischaemic cardiomyopathy (ICM) leads to impaired contraction and ventricular dysfunction causing high rates of morbidity and mortality. Epigenomics allows the identification of epigenetic signatures in human diseases. We analyse the differential epigenetic patterns of ASB gene family in ICM patients and relate these alterations to their ...
arxiv
Epigenetics and Epigenomics: Implications for Diabetes and Obesity
Diabetes, 2018 The American Diabetes Association convened a research symposium, “Epigenetics and Epigenomics: Implications for Diabetes and Obesity” on 17–19 November 2017.
E. Rosen +6 more
semanticscholar +1 more source
Single-cell epigenomic variability reveals functional cancer heterogeneity. [PDF]
, 2017 BackgroundCell-to-cell heterogeneity is a major driver of cancer evolution, progression, and emergence of drug resistance. Epigenomic variation at the single-cell level can rapidly create cancer heterogeneity but is difficult to detect and assess ...
Buenrostro, Jason D +7 more
core +2 more sources
Epigenomics and the Microbiota [PDF]
Toxicologic Pathology, 2014 The mammalian gastrointestinal tract is home to trillions of commensal microorganisms that collectively make up the intestinal microbiota. These microbes are important environmental factors that regulate homeostasis, and alterations in the composition of the microbiota have been associated with several diseases, including inflammatory bowel disease ...
openaire +3 more sources