Results 11 to 20 of about 43,487 (351)
Titration-based normalization of antibody amount improves consistency of ChIP-seq experiments
BMC Genomics, 2023 Chromatin immunoprecipitation (ChIP) is an antibody-based approach that is frequently utilized in chromatin biology and epigenetics. The challenge in experimental variability by unpredictable nature of usable input amounts from samples and undefined ...
Ariel Caride +11 more
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Brain-wide correspondence of neuronal epigenomics and distant projections
Nature, 2023 Single-cell analyses parse the brain’s billions of neurons into thousands of ‘cell-type’ clusters residing in different brain structures^ 1 . Many cell types mediate their functions through targeted long-distance projections allowing interactions between
Jingtian Zhou +50 more
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Epigenomics in stress tolerance of plants under the climate change
Molecular Biology Reports, 2023 Background Climate change has had a tremendous impact on the environment in general as well as agricultural crops grown in these situations as time passed.
Mithlesh Kumar, K. Rani
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Genomics and epigenomics [PDF]
The Journal of Headache and Pain, 2015 Migraine with (MA) and without aura (MO) is a common brain disorder that affects 15% of the general population. Genetic studies on twins have shown that MA and MO heritability spans between 50% and 60%[1]. Despite the high degree of heritability the genetic basis of MA and MO has not been elucidated and on the whole their etiology is far from being ...
Garagnani P. +8 more
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A compendium and comparative epigenomics analysis of cis-regulatory elements in the pig genome
Nature Communications, 2021 Although major advances in genomics have initiated an exciting new era of research, a lack of information regarding cis-regulatory elements has limited the genetic improvement or manipulation of pigs as a meat source and biomedical model.
Yunxia Zhao +15 more
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The Decade of the Epigenomes? [PDF]
Genes & Cancer, 2011 The beginning of this century was not only marked by the publication of the first draft of the human genome but also set off a decade of intense research on epigenetic phenomena. Apart from DNA methylation, it became clear that many other factors including a wide range of histone modifications, different shades of chromatin accessibility, and a vast ...
Martens, J.H.A. +2 more
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Scientific Reports, 2023 Menstruation is a natural phenomenon for every female, starting from adolescents to menopausal age. Any disturbances in menstrual patterns can eventually affect one’s physical as well as psychological health which in turn hamper the quality of life of ...
Shrinjana Dhar +2 more
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Nature Communications, 2018 Over the past decade, remarkable breakthroughs in our understanding of epigenetic biology have coincided with an increased public interest in the impact of diet and lifestyle choices on health. It is well established that a balanced diet enhances life expectancy and helps to prevent or treat certain diseases, such as obesity, diabetes, cancer, and ...
Yi Zhang, Tatiana G. Kutateladze
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Cell, 2007 Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and ...
Alexander Meissner +4 more
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Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders
Genetics in Medicine, 2021 We describe the clinical implementation of genome-wide DNA methylation analysis in rare disorders across the EpiSign diagnostic laboratory network and the assessment of results and clinical impact in the first subjects tested.
B. Sadikovic +25 more
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