Results 11 to 20 of about 64,265 (410)
Nature Reviews Cancer, 2020 Epigenetic regulation is critical to physiological control of development, cell fate, cell proliferation, genomic integrity, and fundamentally, transcriptional regulation. This epigenetic control occurs at multiple levels including through DNA methylation, histone modification, nucleosome remodeling, and modulation of the three-dimensional chromatin ...
Jamie S.E. Yu +8 more
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NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update.
Nucleic Acids Research, 2023 The Gene Expression Omnibus (GEO) is an international public repository that archives gene expression and epigenomics data sets generated by next-generation sequencing and microarray technologies.
Emily Clough +16 more
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Frontiers in Oncology, 2013 It is well known that Neuroblastoma (NB) patients whose tumors have an undifferentiated histology and a transcriptome enriched in cell cycle genes have a worse prognosis. This contrasts with the good prognoses of patients whose tumors have histologic evidence of differentiation and a transcriptome enriched in differentiation genes.
Carol J. Thiele +3 more
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Brain-wide correspondence of neuronal epigenomics and distant projections
Nature, 2023 Single-cell analyses parse the brain’s billions of neurons into thousands of ‘cell-type’ clusters residing in different brain structures^ 1 . Many cell types mediate their functions through targeted long-distance projections allowing interactions between
Jingtian Zhou +50 more
semanticscholar +1 more source
Epigenetic-based therapies for Friedreich ataxia [PDF]
, 2014 This article has been made available through the Brunel Open Access Publishing Fund.Friedreich ataxia (FRDA) is a lethal autosomal recessive neurodegenerative disorder caused primarily by a homozygous GAA repeat expansion mutation within the first intron
Chiranjeevi eSandi +5 more
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Genomics and epigenomics [PDF]
The Journal of Headache and Pain, 2015 Migraine with (MA) and without aura (MO) is a common brain disorder that affects 15% of the general population. Genetic studies on twins have shown that MA and MO heritability spans between 50% and 60%[1]. Despite the high degree of heritability the genetic basis of MA and MO has not been elucidated and on the whole their etiology is far from being ...
Garagnani P. +8 more
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Epigenomics in stress tolerance of plants under the climate change
Molecular Biology Reports, 2023 Background Climate change has had a tremendous impact on the environment in general as well as agricultural crops grown in these situations as time passed.
Mithlesh Kumar, K. Rani
semanticscholar +1 more source
The Decade of the Epigenomes? [PDF]
Genes & Cancer, 2011 The beginning of this century was not only marked by the publication of the first draft of the human genome but also set off a decade of intense research on epigenetic phenomena. Apart from DNA methylation, it became clear that many other factors including a wide range of histone modifications, different shades of chromatin accessibility, and a vast ...
Martens, J.H.A. +2 more
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A compendium and comparative epigenomics analysis of cis-regulatory elements in the pig genome
Nature Communications, 2021 Although major advances in genomics have initiated an exciting new era of research, a lack of information regarding cis-regulatory elements has limited the genetic improvement or manipulation of pigs as a meat source and biomedical model.
Yunxia Zhao +15 more
semanticscholar +1 more source
Scientific Reports, 2023 Menstruation is a natural phenomenon for every female, starting from adolescents to menopausal age. Any disturbances in menstrual patterns can eventually affect one’s physical as well as psychological health which in turn hamper the quality of life of ...
Shrinjana Dhar +2 more
doaj +1 more source