Results 21 to 30 of about 57,741 (321)
Clinical and Translational Medicine, 2022 Background The aberrant differentiation of T follicular helper (Tfh) cells plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanism of regulating Tfh cells differentiation remains unclear.
Limin Liu +11 more
doaj +1 more source
Human Molecular Genetics, 2002 Research in cancer epigenomics is driven by the development of novel technologies and the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades, the search for cancer genes has focused on genetic defects that were used as tags for identification of these genes.
openaire +2 more sources
“Same difference”: comprehensive evaluation of four DNA methylation measurement platforms
Epigenetics & Chromatin, 2018 Background DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are implicated in many diseases, cellular differentiation, imprinting, and other biological ...
Thadeous J. Kacmarczyk +6 more
doaj +1 more source
Genome Medicine, 2021 Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer.
Daniela Mancarella, Christoph Plass
doaj +1 more source
Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application
BMC Genomics, 2017 Background Chromatin immunoprecipitation-sequencing (ChIP-seq) is a widely used epigenetic approach for investigating genome-wide protein-DNA interactions in cells and tissues. The approach has been relatively well established but several key steps still
Jian Zhong +9 more
doaj +1 more source
From obesity resistance to obesity prediction and prevention? [PDF]
, 2016 Comment on: Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction?
Cassano, Tommaso, Gaetani, Silvana
core +4 more sources
A Time-driven Data Placement Strategy for a Scientific Workflow Combining Edge Computing and Cloud Computing [PDF]
, 2019 Compared to traditional distributed computing environments such as grids, cloud computing provides a more cost-effective way to deploy scientific workflows.
Chen, Jiaqing +6 more
core +1 more source
Molecular Medicine, 2023 Background Systemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4+ T-cell activation and imbalanced effector T-cell differentiation play critical roles.
Shuang Lu +11 more
doaj +1 more source
Exercise epigenetics and the foetal origins of disease [PDF]
, 2014 Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core +1 more source
Autoimmunity, 2022 G protein-coupled receptor 183 (GPR183) has been indicated to mediate the migration and localisation of immune cells in T cell-dependent antibody responses.
Mingming Zhao +7 more
doaj +1 more source