Results 31 to 40 of about 64,265 (410)
BMC Research Notes, 2019 Objective DNA methylation analysis via real-time PCR or other analytical techniques requires purified bisulfite converted DNA. We report on an automated high throughput solution for DNA extraction, bisulfite-conversion, and purification of 96 samples ...
Sebastian Rausch +4 more
doaj +1 more source
Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Nature Communications, 2022 Discoid lupus erythematosus (DLE) and systemic LE (SLE) can present as cutaneous lesions. Here the authors characterise an scRNA dataset of cutaneous lesions from these patients and compare these to healthy controls showing differential immune cell ...
Meiling Zheng +16 more
doaj +1 more source
A Time-driven Data Placement Strategy for a Scientific Workflow Combining Edge Computing and Cloud Computing [PDF]
, 2019 Compared to traditional distributed computing environments such as grids, cloud computing provides a more cost-effective way to deploy scientific workflows.
Chen, Jiaqing +6 more
core +1 more source
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci
Circulation Research, 2021 Supplemental Digital Content is available in the text. Rationale: Genome-wide association studies have identified hundreds of loci associated with coronary artery disease (CAD).
T. Örd +12 more
semanticscholar +1 more source
Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
core +1 more source
Enhanced JBrowse plugins for epigenomics data visualization
BMC Bioinformatics, 2018 Background New sequencing techniques require new visualization strategies, as is the case for epigenomics data such as DNA base modifications, small non-coding RNAs, and histone modifications.
Brigitte T. Hofmeister +1 more
doaj +1 more source
The importance of detailed epigenomic profiling of different cell types within organs. [PDF]
, 2016 The human body consists of hundreds of kinds of cells specified from a single genome overlaid with cell type-specific epigenetic information. Comprehensively profiling the body's distinct epigenetic landscapes will allow researchers to verify cell types ...
Borok, Zea +4 more
core +1 more source
Epigenomics, 2021 Epigenomics is the collective study of all epigenetic modifications that can affect the genome, the most pivotal of which are DNA methylation (DNAm), histone modifications (e.g., acetylation, citrullination and phosphorylation) and nucleosome remodeling.
Milad Shirvaliloo
semanticscholar +1 more source
Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq
BMC Genomics, 2019 Background Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples represent the gold standard for archiving pathology samples, and thus FFPE samples are a major ...
Jian Zhong +10 more
doaj +1 more source