Results 41 to 50 of about 64,265 (410)

Chromatin insulator elements: establishing barriers to set heterochromatin boundaries [PDF]

, 2012
Epigenomic profiling has revealed that substantial portions of genomes in higher eukaryotes are organized into extensive domains of transcriptionally repressive chromatin.
Adam G West, Faust, Gomos-Klein, Gráinne Barkess, Hadjur, Hawkins, Hebbes, Ortiz, Roseman, Scott   +9 more
core   +1 more source

Social epigenomics: are we at an impasse?

Epigenomics, 2021
Aim: Social scientists have placed particularly high expectations on the study of epigenomics to explain how exposure to adverse social factors like poverty, child maltreatment and racism - particularly early in childhood - might contribute to complex ...
A. Non
semanticscholar   +1 more source

The pathological role of B cells in systemic lupus erythematosus: From basic research to clinical

Autoimmunity, 2020
Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in females of child-bearing age. It involves multiple systems and severely threatens human life.
Yu Feng, Ming Yang, Haijing Wu, Qianjin Lu   +3 more
doaj   +1 more source

Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation

Genome Medicine, 2021
Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer.
Daniela Mancarella, Christoph Plass
doaj   +1 more source

Zipper plot : visualizing transcriptional activity of genomic regions [PDF]

, 2017
Background: Reconstructing transcript models from RNA-sequencing (RNA-seq) data and establishing these as independent transcriptional units can be a challenging task.
Anckaert, Jasper, Avila Cobos, Francisco, De Preter, Katleen, Everaert, Celine, Mestdagh, Pieter, Rombaut, Dries, Vandesompele, Jo, Volders, Pieter-Jan   +7 more
core   +4 more sources

The SEQC2 epigenomics quality control (EpiQC) study

Genome Biology, 2021
Background Cytosine modifications in DNA such as 5-methylcytosine (5mC) underlie a broad range of developmental processes, maintain cellular lineage specification, and can define or stratify types of cancer and other diseases.
J. Foox, J. Nordlund, C. Lalancette, Ting Gong, M. Lacey, Samantha Lent, B. Langhorst, V. C. Ponnaluri, Louise Williams, Karthik Padmanabhan, Raymond G. Cavalcante, Anders Lundmark, D. Butler, C. Mozsary, Justin Gurvitch, J. Greally, Masako Suzuki, Mark Menor, Masaki Nasu, A. Alonso, Caroline Sheridan, A. Scherer, Steve Bruinsma, Gosia Golda, A. Muszyńska, Paweł P. Łabaj, Matthew A. Campbell, Frank Wos, A. Raine, U. Liljedahl, T. Axelsson, Charles Wang, Zhong Chen, Zhaowei Yang, Jing Li, Xiaopeng Yang, Hongwei Wang, A. Melnick, Shang Guo, A. Blume, V. Franke, I. Ibáñez de Cáceres, C. Rodríguez‐Antolín, Rocío Rosas, J. Davis, J. Ishii, D. Megherbi, Wenming Xiao, W. Liao, Joshua Xu, H. Hong, B. Ning, W. Tong, A. Akalin, Yunliang Wang, Youping Deng, Christopher E. Mason   +56 more
semanticscholar   +1 more source

“Same difference”: comprehensive evaluation of four DNA methylation measurement platforms

Epigenetics & Chromatin, 2018
Background DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are implicated in many diseases, cellular differentiation, imprinting, and other biological ...
Thadeous J. Kacmarczyk, Mame P. Fall, Xihui Zhang, Yuan Xin, Yushan Li, Alicia Alonso, Doron Betel   +6 more
doaj   +1 more source

m6A methyltransferase METTL3 programs CD4+ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus

Molecular Medicine, 2023
Background Systemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4+ T-cell activation and imbalanced effector T-cell differentiation play critical roles.
Shuang Lu, Xingyu Wei, Huan Zhu, Zhi Hu, Meiling Zheng, Jiali Wu, Cheng Zhao, Shuang Yang, Delong Feng, Sujie Jia, Hongjun Zhao, Ming Zhao   +11 more
doaj   +1 more source

Deep learning-based enhancement of epigenomics data with AtacWorks

Nature Communications, 2021
ATAC-seq is a widely-applied assay used to measure genome-wide chromatin accessibility; however, its ability to detect active regulatory regions can depend on the depth of sequencing coverage and the signal-to-noise ratio.
Avantika Lal, Zachary D. Chiang, Nikolai Yakovenko, Fabiana M. Duarte, Johnny Israeli, Jason D. Buenrostro   +5 more
semanticscholar   +1 more source

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

BMC Genomics, 2017
Background Chromatin immunoprecipitation-sequencing (ChIP-seq) is a widely used epigenetic approach for investigating genome-wide protein-DNA interactions in cells and tissues. The approach has been relatively well established but several key steps still
Jian Zhong, Zhenqing Ye, Samuel W. Lenz, Chad R. Clark, Adil Bharucha, Gianrico Farrugia, Keith D. Robertson, Zhiguo Zhang, Tamas Ordog, Jeong-Heon Lee   +9 more
doaj   +1 more source