Results 41 to 50 of about 55,460 (328)
Probing the cancer genome [PDF]
, 2011 A report on the Keystone Symposium 'Cancer Genomics and Epigenomics', Taos, USA, 19-24 February ...
Greulich, Heidi E.
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The allure of the epigenome [PDF]
Genome Biology, 2012 The Oxford English Dictionary dates the word 'genome' to 1926 but has not yet seen fit to include the term 'epigenome' in its illustrious pages (where it would reside handsomely between 'epigenist' and 'epigenous'). This differential treatment reflects a state of affairs in which the epigenome has yet to infiltrate the popular imagination, but belies ...
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Molecular Cell, 2016 During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline.
Lauren N. Booth, Anne Brunet
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Nature Communications, 2022 While cutaneous melanoma is linked to UV radiation, acral melanoma is not. Epigenetic mechanisms function as sensors to exposures and determinants of cell identity.
Anna Luiza Silva Almeida Vicente +12 more
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A Time-driven Data Placement Strategy for a Scientific Workflow Combining Edge Computing and Cloud Computing [PDF]
, 2019 Compared to traditional distributed computing environments such as grids, cloud computing provides a more cost-effective way to deploy scientific workflows.
Chen, Jiaqing +6 more
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Nature Reviews Immunology, 2021 A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
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What is a Gene? A Two Sided View [PDF]
, 2017 The need to account for all currently available experimental observations concerning the gene nature, has reshaped the concept of gene turning it from the essentially mechanistic unit, predominant during the '70s, into a quite abstract open ...
Bolondi, A. +8 more
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eLife, 2022 A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
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The Epigenome in Atherosclerosis [PDF]
, 2020 AbstractEmerging evidence suggests the growing importance of “nongenetic factors” in the pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines only part of the risk profile as genomic approaches do not take into account additional layers of biological regulation by “epi”-genetic changes.
Francesco Paneni, Sarah Costantino
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Epigenomics of macrophages [PDF]
Immunological Reviews, 2014 SummaryMacrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly ...
Christopher K. Glass, David Gosselin
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