Results 41 to 50 of about 43,487 (351)

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

BMC Genomics, 2017
Background Chromatin immunoprecipitation-sequencing (ChIP-seq) is a widely used epigenetic approach for investigating genome-wide protein-DNA interactions in cells and tissues. The approach has been relatively well established but several key steps still
Jian Zhong, Zhenqing Ye, Samuel W. Lenz, Chad R. Clark, Adil Bharucha, Gianrico Farrugia, Keith D. Robertson, Zhiguo Zhang, Tamas Ordog, Jeong-Heon Lee   +9 more
doaj   +1 more source

m6A methyltransferase METTL3 programs CD4+ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus

Molecular Medicine, 2023
Background Systemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4+ T-cell activation and imbalanced effector T-cell differentiation play critical roles.
Shuang Lu, Xingyu Wei, Huan Zhu, Zhi Hu, Meiling Zheng, Jiali Wu, Cheng Zhao, Shuang Yang, Delong Feng, Sujie Jia, Hongjun Zhao, Ming Zhao   +11 more
doaj   +1 more source

Interpretation of deep learning in genomics and epigenomics

Briefings Bioinform., 2020
Machine learning methods have been widely applied to big data analysis in genomics and epigenomics research. Although accuracy and efficiency are common goals in many modeling tasks, model interpretability is especially important to these studies towards
Amlan Talukder, Clayton Barham, X. Li, Haiyan Hu   +3 more
semanticscholar   +1 more source

Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure

Nature Communications, 2022
While cutaneous melanoma is linked to UV radiation, acral melanoma is not. Epigenetic mechanisms function as sensors to exposures and determinants of cell identity.
Anna Luiza Silva Almeida Vicente, Alexei Novoloaca, Vincent Cahais, Zainab Awada, Cyrille Cuenin, Natália Spitz, André Lopes Carvalho, Adriane Feijó Evangelista, Camila Souza Crovador, Rui Manuel Reis, Zdenko Herceg, Vinicius de Lima Vazquez, Akram Ghantous   +12 more
doaj   +1 more source

Epigenomics of macrophages [PDF]

Immunological Reviews, 2014
SummaryMacrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly ...
Christopher K. Glass, David Gosselin
openaire   +2 more sources

Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients

Autoimmunity, 2022
G protein-coupled receptor 183 (GPR183) has been indicated to mediate the migration and localisation of immune cells in T cell-dependent antibody responses.
Mingming Zhao, Yang Mei, Zhidan Zhao, Pengpeng Cao, Yue Xin, Yunkai Guo, Ming Yang, Haijing Wu   +7 more
doaj   +1 more source

The contribution of ethnography to epigenomics research: toward a new bio-ethnography for addressing health disparities.

Epigenomics, 2021
This article describes ethnography as a research method and outlines how it excels in capturing the salient experiences of individuals among diverse communities in their own words.
M. Lock, M. Argentieri, Alexandra E. Shields   +2 more
semanticscholar   +1 more source

Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation

Genome Medicine, 2021
Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer.
Daniela Mancarella, Christoph Plass
doaj   +1 more source

The allure of the epigenome [PDF]

Genome Biology, 2012
The Oxford English Dictionary dates the word 'genome' to 1926 but has not yet seen fit to include the term 'epigenome' in its illustrious pages (where it would reside handsomely between 'epigenist' and 'epigenous'). This differential treatment reflects a state of affairs in which the epigenome has yet to infiltrate the popular imagination, but belies ...
openaire   +3 more sources

Immune epigenome [PDF]

Nature Reviews Immunology, 2021
A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
openaire   +2 more sources