Results 51 to 60 of about 43,487 (351)
Nature Communications, 2021 Muco-obstructive lung diseases are characterised by airway macrophage (AM) populations which may have epigenetic changes. Here using a mouse model the authors show epigenetic alteration of AMs with changes in LPS response, phagocytosis and efferocytosis ...
Joschka Hey +9 more
doaj +1 more source
eLife, 2022 A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
openaire +3 more sources
Molecular Cell, 2016 During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline.
Lauren N. Booth, Anne Brunet
openaire +3 more sources
PLoS ONE, 2021 We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer’s Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 late ...
R. Bahado-Singh +13 more
semanticscholar +1 more source
Quality control and evaluation of plant epigenomics data
The Plant Cell, 2021 Epigenomics is the study of molecular signatures associated with discrete regions within genomes, many of which are important for a wide range of nuclear processes. The ability to profile the epigenomic landscape associated with genes, repetitive regions,
Robert J. Schmitz +10 more
semanticscholar +1 more source
The Epigenome in Atherosclerosis [PDF]
, 2020 AbstractEmerging evidence suggests the growing importance of “nongenetic factors” in the pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines only part of the risk profile as genomic approaches do not take into account additional layers of biological regulation by “epi”-genetic changes.
Francesco Paneni, Sarah Costantino
openaire +2 more sources
Cancers, 2021 Simple Summary Ovarian cancer is the leading cause of death by a gynecological tumor, mainly due to its common detection in advanced stages and to its high resistance to conventional chemotherapy.
S. Muñoz-Galván, A. Carnero
semanticscholar +1 more source
Current Opinion in Nephrology and Hypertension, 2020 Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease.Reversible DNA and histone modifications influence chromatin accessibility and can be measured by ...
Nicolas Ledru +2 more
openaire +3 more sources
Epigenomics of Hypertension [PDF]
Seminars in Nephrology, 2013 Multiple genes and pathways are involved in the pathogenesis of hypertension. Epigenomic studies of hypertension are beginning to emerge and hold great promise of providing novel insights into the mechanisms underlying hypertension. Epigenetic marks or mediators including DNA methylation, histone modifications, and noncoding RNA can be studied at a ...
Theodore A. Kotchen +4 more
openaire +3 more sources