Results 61 to 70 of about 57,741 (321)

EpiCHAOS: a metric to quantify epigenomic heterogeneity in single-cell data

Genome Biology
Epigenetic heterogeneity is a fundamental property of biological systems and is recognized as a potential driver of tumor plasticity and therapy resistance.
Katherine Kelly, Michael Scherer, Martina Maria Braun, Pavlo Lutsik, Christoph Plass   +4 more
doaj   +1 more source

Implementing Curcumin in Translational Oncology Research

Molecules, 2020
Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals.
Koraljka Gall Trošelj, Ivana Samaržija, Marko Tomljanović, Renata Novak Kujundžić, Nikola Đaković, Anamarija Mojzeš   +5 more
doaj   +1 more source

Ferroptosis Activation Contributes to the Formation of Skin Lesions in Psoriasis Vulgaris

Antioxidants, 2023
(1) Background: Ferroptosis is a newly coined form of programmed cell death marked by lethal accumulation of lipid peroxidation and ferrous iron overload.
Siying Li, Xin Luo, Suhan Zhang, Yuwen Su, Min Deng, Yanshan Zhu, Peng Zhang, Ruifang Wu, Ming Zhao   +8 more
doaj   +1 more source

Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes [PDF]

, 2015
AIM: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no studies have interrogated this epigenetic modification in early disease.
Anthony A Fryer, Benjamini Y, Derek L Mattey, John R Glossop, Jon C Packham, Li JP, Nicola B Nixon, Richard D Emes, William E Farrell   +8 more
core   +2 more sources

Epigenomics-Based Diagnostics [PDF]

Clinical Chemistry, 2010
The term “epigenetics,” first coined in 1942, refers to heritable traits of cells (over many rounds of cell division) that do not involve changes to the underlying DNA sequence. The 2 predominant epigenetic mechanisms are DNA methylation and histone modification.
Eleftherios P, Diamandis, David, Sidransky, Peter W, Laird, Paul, Cairns, Bharati, Bapat   +4 more
openaire   +2 more sources

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Andrews, TD, Beck, S, Berlin, K, Cox, AV, Fischer, J, Gut, IG, Hildmann, T, Howe, KL, Lewin, J, Novik, KL, Olek, A, Otto, T, Rakyan, VK, Tost, J   +13 more
core  

CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions

Advanced Science, EarlyView.
CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, Yiyang Zhang, Wentao Cui, Yao Chen, Shirui Li, Wenhao Liu, Yao Tian, Yana Liu, Jingxi Dong, Ping Xu, Zhenpeng Man, Guole Liu, Zhongming Liang, Xinlong Jiang, Xiaodong Yang, Pengfei Wang, Ge Yang, Hongmei Wang, Xuezhi Wang, Ming‐Han Tong, Yuanchun Zhou, Shihua Zhang, Yiqiang Chen, Yong Wang, Xin Li   +27 more
wiley   +1 more source

Personalized medicine—a modern approach for the diagnosis and management of hypertension [PDF]

, 2017
The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage.
Borghi, Claudio, Grassi, Guido, Rosei, Enrico Agabiti, Savoia, Carmine, Touyz, Rhian M., Volpe, Massimo   +5 more
core   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source