Extracellular cleavage of E-cadherin promotes epithelial cell extrusion [PDF]
Journal of Cell Science, 2014 Epithelial cell extrusion and subsequent apoptosis is a key mechanism to prevent accumulation of excess cells. Conversely, when driven by oncogene expression, apical cell extrusion is followed by proliferation and represents an initial step of tumorigenesis.
Grieve, Adam G, Rabouille, Catherine
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E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness. [PDF]
PLoS ONE, 2017 Ovarian cancer (OC) is the fifth cancer death cause in women worldwide. The malignant nature of this disease stems from its unique dissemination pattern.
Marina Rosso +16 more
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TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair. [PDF]
, 2016 E-cadherin is a cell adhesion molecule best known for its function in suppressing tumor progression and metastasis. Here we show that E-cadherin promotes nucleotide excision repair through positively regulating the expression of xeroderma pigmentosum ...
Barcellos-Hoff, MH +3 more
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PALS1 Regulates E-Cadherin Trafficking in Mammalian Epithelial Cells [PDF]
Molecular Biology of the Cell, 2007 Protein Associated with Lin Seven 1 (PALS1) is an evolutionarily conserved scaffold protein that targets to the tight junction in mammalian epithelia. Prior work in our laboratory demonstrated that the knockdown of PALS1 in Madin Darby canine kidney cells leads to tight junction and polarity defects.
Qian, Wang +2 more
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Interactions and Feedbacks in E-Cadherin Transcriptional Regulation
Frontiers in Cell and Developmental Biology, 2021 Epithelial tissues rely on the adhesion between participating cells to retain their integrity. The transmembrane protein E-cadherin is the major protein that mediates homophilic adhesion between neighbouring cells and is, therefore, one of the critical ...
Miguel Ramirez Moreno +2 more
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Snail in the frame of malignant tumor recurrence [PDF]
, 2006 A
De Craene, Bram, Berx, Geert
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Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. [PDF]
, 2016 Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions.
Hammock, Bruce D +5 more
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Epithelial Viscoelasticity Is Regulated by Mechanosensitive E-cadherin Turnover [PDF]
Current Biology, 2019 Studying how epithelia respond to mechanical stresses is key to understanding tissue shape changes during morphogenesis. Here, we study the viscoelastic properties of the Drosophila wing epithelium during pupal morphogenesis by quantifying mechanical stress and cell shape as a function of time.
Iyer, K. +4 more
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E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors [PDF]
Cancers, 2021 Inactivating germline mutations in the CDH1 gene (encoding the E-cadherin protein) are the genetic hallmark of hereditary diffuse gastric cancer (HDGC), and somatic CDH1 mutations are an early event in the development of sporadic diffuse gastric cancer (DGC) and lobular breast cancer (LBC).
Lyvianne Decourtye-Espiard +6 more
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Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer. [PDF]
, 2016 The poor prognosis for patients with inflammatory breast cancer (IBC) compared to patients with other types of breast cancers emphasizes the need to better understand the molecular underpinnings of this disease with the goal of developing effective ...
Boerner, Julie +11 more
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