Results 41 to 50 of about 195,613 (192)
PLoS Genetics, 2019 E-cadherin complexes with the actin cytoskeleton via cytoplasmic catenins and maintains the functional characteristics and integrity of the epithelia in normal epithelial tissues.
Adam Olson +10 more
doaj +1 more source
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
core +2 more sources
Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
core +1 more source
Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation [PDF]
Biology Open, 2012 Summary Proper regulation of the formation and stabilization of epithelial cell–cell adhesion is crucial in embryonic morphogenesis and tissue repair processes. Defects in this process lead to organ malformation and defective epithelial barrier function. A combination of chemical and mechanical cues is used by cells to drive this process.
Twiss, F.D. +9 more
openaire +4 more sources
Molecular cloning and characterization of B-cadherin, a novel chick cadherin. [PDF]
, 1991 Calcium-dependent cell-cell adhesion is mediated in large part by a set of homologous integral membrane glycoproteins termed cadherins. In this report, antibodies to conserved domains in previously described cadherins have been used to isolate cDNAs ...
Napolitano, EW +3 more
core +2 more sources
ZEB1 is Negatively Correlated with E-Cadherin in Prostatic Anomaly Tissue
MCBS (Molecular and Cellular Biomedical Sciences), 2022 Background: Prostatic anomalies are common in tumor or infection condition. The enlargement of prostate gland affects the epithelial cell polarity that involves epithelial-mesenchymal transition (EMT).
Sari Eka Pratiwi +7 more
doaj +1 more source
E‐Cadherin/β‐Catenin Complex and the Epithelial Barrier [PDF]
BioMed Research International, 2011 E‐Cadherin/β‐catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt‐signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial ...
Tian, Xinrui +8 more
openaire +2 more sources
GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells
Cell Reports, 2019 Summary: O-GalNAc glycosylation is initiated in the Golgi by glycosyltransferases called GALNTs. Proteomic screens identified >600 O-GalNAc-modified proteins, but the biological relevance of these modifications has been difficult to determine.
Deepthi Raghu +4 more
doaj +1 more source
E-Cadherin in Pancreatic Ductal Adenocarcinoma: A Multifaceted Actor during EMT
Cells, 2020 Epithelial-to-mesenchymal transition (EMT) is a step-wise process observed in normal and tumor cells leading to a switch from epithelial to mesenchymal phenotype.
Michele Sommariva, Nicoletta Gagliano
doaj +1 more source
Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer [PDF]
, 2016 Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered ...
A G Pockley +45 more
core +1 more source