Role of epithelial sodium channel-related inflammation in human diseases [PDF]
Frontiers in Immunology, 2023 The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout the kidneys, blood vessels, lungs, colons, and many other organs.
Yabin Chen +11 more
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The Epithelial Sodium Channel-An Underestimated Drug Target. [PDF]
Int J Mol Sci, 2023 Epithelial sodium channels (ENaC) are part of a complex network of interacting biochemical pathways and as such are involved in several disease states. Dependent on site and type of mutation, gain- or loss-of-function generated symptoms occur which span ...
Lemmens-Gruber R, Tzotzos S.
europepmc +5 more sources
Epithelial Sodium Channel and Salt-Sensitive Hypertension. [PDF]
Hypertension, 2021 The development of high blood pressure is influenced by genetic and environmental factors, with high salt intake being a known environmental contributor.
Mutchler SM, Kirabo A, Kleyman TR.
europepmc +5 more sources
Molecular principles of assembly, activation, and inhibition in epithelial sodium channel [PDF]
eLife, 2020 The molecular bases of heteromeric assembly and link between Na+ self-inhibition and protease-sensitivity in epithelial sodium channels (ENaCs) are not fully understood.
Sigrid Noreng +4 more
doaj +3 more sources
Sodium channels and mammalian sensory mechanotransduction [PDF]
Molecular Pain, 2012 Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin +7 more
doaj +6 more sources
The epithelial sodium channel in inflammation and blood pressure modulation [PDF]
Frontiers in Cardiovascular Medicine, 2023 A major regulator of blood pressure and volume homeostasis in the kidney is the epithelial sodium channel (ENaC). ENaC is composed of alpha(α)/beta(β)/gamma(γ) or delta(δ)/beta(β)/gamma(γ) subunits.
Taseer Ahmad +7 more
doaj +2 more sources
Metformin Alleviates Diabetes-Associated Hypertension by Attenuating the Renal Epithelial Sodium Channel [PDF]
Biomedicines, 2023 Diabetic nephropathy is the primary cause of morbidity in type 2 diabetes mellitus (T2DM) patients. New data indicate that hypertension, a common comorbidity in T2DM, can worsen outcomes of diabetic nephropathy.
Yogesh M. Scindia +11 more
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Structure of the human epithelial sodium channel by cryo-electron microscopy
eLife, 2018 The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na+ and water homeostasis. ENaCs assemble as heterotrimeric channels that harbor protease-sensitive domains critical for gating the channel.
Sigrid Noreng +4 more
doaj +2 more sources
Epithelial Sodium Channel Alpha Subunit (αENaC) Is Associated with Inverse Salt Sensitivity of Blood Pressure [PDF]
Biomedicines, 2022 Salt sensitivity of blood pressure (BP) refers to an increase in BP following an increase in dietary salt, which is associated with increased incidence of cardiovascular disease and early death.
Peng Xu +8 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Mineralocorticoid receptor (MR) has pathological roles in various cell types, including renal tubule cells, myocytes, and smooth muscle cells; however, the role of MR in intestinal epithelial cells (IECs) has not been sufficiently evaluated ...
Toshifumi Nakamura +11 more
doaj +2 more sources