Results 21 to 30 of about 212,176 (344)

A novel nonsense mutation in the β-subunit of the epithelial sodium channel causing Liddle syndrome

Blood Pressure, 2021
Purpose Liddle syndrome is a hereditary form of arterial hypertension caused by mutations in the genes coding of the epithelial sodium channel – SCNN1A, SCNN1B and SCNN1G.
Štěpán Mareš, Jan Filipovský, Kateřina Vlková, Martin Pešta, Václava Černá, Jaroslav Hrabák, Jitka Mlíková Seidlerová, Otto Mayer   +7 more
doaj   +1 more source

Effect of kokumi taste-active γ-glutamyl peptides on amiloride-sensitive epithelial Na+ channels in rat fungiform taste cells

Biochemistry and Biophysics Reports, 2023
Kokumi taste-active compounds enhance salty taste perception. In animal models, sodium (salt) detection is mediated by the amiloride-sensitive epithelial sodium channel, ENaC.
Albertino Bigiani, MeeRa Rhyu
doaj   +1 more source

Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner

The Journal of General Physiology, 2020
In murine cortical collecting duct cells, prostaglandin E2 (PGE2) stimulates transepithelial sodium transport mediated by the epithelial sodium channel (ENaC). PGE2 is synthesized and secreted by the cells and acts on basolateral prostaglandin E receptor
M. Mansley, Christian Niklas, Regina Nacken, K. Mandery, H. Glaeser, M. Fromm, C. Korbmacher, M. Bertog   +7 more
semanticscholar   +1 more source

Failure to Downregulate the Epithelial Sodium Channel Causes Salt Sensitivity in Hsd11b2 Heterozygote Mice [PDF]

, 2012
In vivo, the enzyme 11β-hydroxysteroid dehydrogenase type 2 influences ligand access to the mineralocorticoid receptor. Ablation of the encoding gene, HSD11B2, causes the hypertensive syndrome of apparent mineralocorticoid excess.
Bailey, Matthew A, Craigie, Eilidh, Evans, Louise C, Mullins, John J   +3 more
core   +1 more source

Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundDuring high sodium intake, the renin‐angiotensin‐aldosterone system is downregulated and nitric oxide signaling is upregulated in order to remain in sodium balance.
Kelly A. Hyndman, Elena V. Mironova, Jorge F. Giani, Courtney Dugas, Jessika Collins, Alicia A. McDonough, James D. Stockand, Jennifer S. Pollock   +7 more
doaj   +1 more source

Prostasin: An Epithelial Sodium Channel Regulator [PDF]

Journal of Biomarkers, 2013
Prostasin is a glycophosphatidylinositol-anchored protein which is found in prostate gland, kidney, bronchi, colon, liver, lung, pancreas, and salivary glands. It is a serine protease with trypsin-like substrate specificity which was first purified from seminal fluid in 1994. In the last decade, its diverse roles in various biological and physiological
Shakti Aggarwal, Pradeep K. Dabla, Sarika Arora   +2 more
openaire   +2 more sources

Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1

Cells, 2023
Background: In patients with diarrhea-predominant irritable bowel syndrome (IBS-D), the diarrheal mechanisms are largely unknown, and they were examined in this study on colon biopsies.
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Jörg-Dieter Schulzke, Roland Bücker   +7 more
doaj   +1 more source

Cleavage of endogenous gamma ENaC and elevated abundance of alpha ENaC are associated with increased Na+ transport in response to apical fluid volume expansion in human H441 airway epithelial cells [PDF]

, 2011
Using human H441 airway epithelial cells cultured at air–liquid interface (ALI), we have uniquely correlated the functional response to apical fluid volume expansion with the abundance and cleavage of endogenous α- and γENaC proteins in the apical ...
Baines, DL, Selvanathar, IA, Tan, CD
core   +2 more sources

Functional Domains of the Epithelial Sodium Channel [PDF]

Journal of the American Society of Nephrology, 2005
The epithelial sodium channel (ENaC) plays an important role in ion transport of many organ systems. In kidney, colon, and sweat gland, ENaC-mediated transepithelial sodium transport helps to adjust sodium excretion in the urine, feces, and sweat to fulfill homeostatic requirements.
Loffing, Johannes, Schild, Laurent
openaire   +3 more sources

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
core   +1 more source