Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC [PDF]
Molecular Brain, 2019 This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels in the thalamus and hypothalamus as detected ...
Agustin Garcia-Caballero +7 more
doaj +6 more sources
Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4. [PDF]
PLoS ONE, 2015 The membrane-bound serine protease CAP2/Tmprss4 has been previously identified in vitro as a positive regulator of the epithelial sodium channel (ENaC).
Anna Keppner +9 more
doaj +6 more sources
The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. [PDF]
PLoS ONE, 2012 The epithelial sodium channel (ENaC) is the rate-limiting step for sodium reabsorption across tight epithelia. Cyclic-AMP (cAMP) stimulation promotes ENaC trafficking to the apical surface to increase channel number and transcellular Na(+) transport ...
Robert S Edinger +5 more
doaj +7 more sources
The role of the epithelial Na+ channel (ENaC) in high AVP but low aldosterone states [PDF]
Frontiers in Physiology, 2012 Due to the abundance of seminal discoveries establishing a strong causal relation between changes in aldosterone signaling, the activity of the epithelial Na+ channel (ENaC) and blood pressure, the role of ENaC in health and disease is understood almost ...
James D Stockand
doaj +3 more sources
Sodium channels and mammalian sensory mechanotransduction [PDF]
Molecular Pain, 2012 Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin +7 more
doaj +6 more sources
Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation [PDF]
Experimental and Molecular Medicine, 2019 Blood pressure: Estrogen maintains the balance Estrogen treatment could prove valuable in tackling high blood pressure (hypertension) in postmenopausal women. Long-term healthy blood pressure is linked to the correct regulation of sodium and water levels
Xue Zhang +8 more
doaj +2 more sources
Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC)Research in context [PDF]
EBioMedicine, 2019 Background: Autosomal Recessive Polycystic Kidney Disease (ARPKD) is marked by cyst formation in the renal tubules, primarily in the collecting duct (CD) system, ultimately leading to end-stage renal disease.
Daria V. Ilatovskaya +8 more
doaj +2 more sources
Aldosterone Modulates the Association between NCC and ENaC [PDF]
Scientific Reports, 2017 Distal sodium transport is a final step in the regulation of blood pressure. As such, understanding how the two main sodium transport proteins, the thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC), are ...
Brandi M. Wynne +6 more
doaj +2 more sources
Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis [PDF]
Scientific Reports, 2017 The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function.
Maria D. I. Manunta +8 more
doaj +2 more sources
Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro‐inflammatory in labor [PDF]
EMBO Molecular Medicine, 2018 The shift of cytokine profile from anti‐ to pro‐inflammatory is the most recognizable sign of labor, although the underlying mechanism remains elusive. Here, we report that the epithelial sodium channel (ENaC) is upregulated and activated in the uterus ...
Xiao Sun +15 more
doaj +2 more sources