Results 101 to 110 of about 14,256 (219)

GENETIC VARIATION IN CYP4A11 AND BLOOD PRESSURE RESPONSE TO MINERALOCORTICOID RECEPTOR ANTAGONISM OR ENAC INHIBITION: AN EXPLORATORY PILOT STUDY IN AFRICAN AMERICANS [PDF]

, 2014
Background An rs3890011 variant of CYP4A11, which is in linkage disequilibrium with the loss-of-function variant rs1126742, is associated with hypertension in humans. In mice, Cyp4a deficiency results in salt-sensitive hypertension through activation of
Brown, Nancy J., Eckert, George J., Elijovich, Fernando, Laffer, Cheryl L., Pratt, J. Howard, Tu, Wanzhu   +5 more
core   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells.

PLoS ONE
The airway epithelium plays a pivotal role in regulating mucosal immunity and inflammation. Epithelial barrier function, homeostasis of luminal fluid, and mucociliary clearance are major components of mucosal defense mechanisms.
Anusree Sasidharan, Astrid Grosche, Xiaodong Xu, T Bernard Kinane, Damiano Angoli, Sadasivan Vidyasagar   +5 more
doaj   +1 more source

Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]

, 2019
As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M, Nguyen, Hai M, Wulff, Heike   +2 more
core   +1 more source

Screening and Diagnosis of Primary Aldosteronism in Patients Using Renin‐Angiotensin System Inhibitors

The Journal of Clinical Hypertension, Volume 28, Issue 1, January 2026.
ABSTRACT This study investigated whether patients receiving renin‐angiotensin system inhibitors (RASIs) can undergo reliable screening for primary aldosteronism (PA) without discontinuation of therapy. Consecutive patients with hypertension who underwent PA screening at our hospital between 2016 and 2024 while on RASIs were recruited.
Qian Wang, Hui Dong, Hong‐Wu Li, Yu‐Bao Zou, Xiong‐Jing Jiang   +4 more
wiley   +1 more source

Effects of CFTR-ENaC on spinal cord edema after spinal cord injury

Open Medicine
To explore the role of cystic fibrosis transmembrane conduction regulator (CFTR)-Epithelial sodium channel (ENaC) in spinal cord edema after spinal cord injury (SCI) and the related mechanism.
Shen Guowei, Zhang Yunpeng, Cheng Xinkun, Li Dongdong, Ding Zhiyong, Tian Jiwei, Chen Hui, Ding Huiming   +7 more
doaj   +1 more source

Aldosterone upregulates transient receptor potential melastatin 7 (TRPM7) [PDF]

, 2016
Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed Mg2+-permeable ion channel fused to a C-terminal α-kinase domain. Recently, aldosterone was shown to increase intracellular Mg2+ levels and alter inflammatory signaling in ...
Jolly, Anna, Miquel, Perrine, Shrier, Alvin, Touyz, Rhian M., Valinsky, William C.   +4 more
core   +1 more source

Regulation of the epithelial sodium channel (ENaC) by membrane trafficking

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010
The epithelial Na(+) channel (ENaC) is a major regulator of salt and water reabsorption in a number of epithelial tissues. Abnormalities in ENaC function have been directly linked to several human disease states including Liddle syndrome, psuedohypoaldosteronism, and cystic fibrosis and may be implicated in salt-sensitive hypertension. ENaC activity in
openaire   +2 more sources

Increased renal α-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010
Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear. We first used a targeted proteomics approach and found that there were no changes in the protein abundance compared with virgin rats of the β or γ ENaC, type 3 Na+/H ...
Crystal, West, Zheng, Zhang, Geoffrey, Ecker, Shyama M E, Masilamani   +3 more
openaire   +3 more sources

Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells

Respiratory Research, 2010
Background Hyperactivity of the epithelial sodium (Na+) channel (ENaC) and increased Na+ absorption by airway epithelial cells leading to airway surface liquid dehydration and impaired mucociliary clearance are thought to play an important role in the ...
Clerici Christine, Prulière-Escabasse Virginie, Vuagniaux Grégoire, Coste Andre, Escudier Estelle, Planès Carole   +5 more
doaj   +1 more source