Physiological levels of lipoxin A4 inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium. [PDF]
, 2014 In cystic fibrosis (CF), the airway surface liquid (ASL) is depleted. We previously demonstrated that lipoxin A4 (LXA4) can modulate ASL height (ASLh) through actions on Cl(-) transport.
Al-Alawi, Mazen +8 more
core +5 more sources
Sodium selectivity of semicircular canal duct epithelial cells
BMC Research Notes, 2011 Background Sodium absorption by semicircular canal duct (SCCD) epithelial cells is thought to contribute to the homeostasis of the volume of vestibular endolymph.
Harbidge Donald G +4 more
doaj +1 more source
Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis [PDF]
, 2017 Removal of renal mass stimulates anatomical and functional adaptations in the surviving nephrons, including elevations in single-nephron glomerular filtration rate (SNGFR) and tubular hypertrophy. A goal of this study is to assess the extent to which the
Edwards, Aurelie +2 more
core +1 more source
mTORC2 critically regulates renal potassium handling [PDF]
, 2016 The mTOR pathway orchestrates cellular homeostasis. The rapamycin-sensitive mTOR complex (mTORC1) in the kidney has been widely studied; however, mTORC2 function in renal tubules is poorly characterized.
Ahmed, Azaz +14 more
core +1 more source
A variant of ASIC2 mediates sodium retention in nephrotic syndrome
JCI Insight, 2021 Idiopathic nephrotic syndrome (INS) is characterized by proteinuria and renal sodium retention leading to edema. This sodium retention is usually attributed to epithelial sodium channel (ENaC) activation after plasma aldosterone increase.
Marc Fila +18 more
doaj +1 more source
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC) [PDF]
, 2018 The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule 2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium (Na+) absorption in the ASDN is essential to precisely match urinary ...
Korbmacher, Christoph, Loffing, Johannes
core
Dexamethasone and insulin activate serum and glucocorticoid-inducible kinase 1 (SGK1) via different molecular mechanisms in cortical collecting duct cells [PDF]
, 2016 Serum and glucocorticoid‐inducible kinase 1 (SGK1) is a protein kinase that contributes to the hormonal control of renal Na+ retention by regulating the abundance of epithelial Na+ channels (ENaC) at the apical surface of the principal cells of the ...
Alessi +48 more
core +4 more sources
Clinical Application of Epithelial Sodium Channel (ENaC) as a Biomarker for Arterial Hypertension. [PDF]
Biosensors (Basel), 2022 García-Rubio D +4 more
europepmc +1 more source
COVID-19 and Liquid Homeostasis in the Lung-A Perspective through the Epithelial Sodium Channel (ENaC) Lens. [PDF]
Cells, 2022 Brown EF, Mitaera T, Fronius M.
europepmc +1 more source
Role of the ubiquitin system in regulating ion transport [PDF]
, 2018 Ion channels and transporters play a critical role in ion and fluid homeostasis and thus in normal animal physiology and pathology. Tight regulation of these transmembrane proteins is therefore essential.
Rotin, Daniela, Staub, Olivier
core