Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors. [PDF]
PLoS One, 2014 The serralysin family of metalloproteases is associated with the virulence of multiple gram-negative human pathogens, including Pseudomonas aeruginosa and Serratia marcescens.
Butterworth MB +4 more
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Proteolytic Activation of the Epithelial Sodium Channel (ENaC): Its Mechanisms and Implications. [PDF]
Int J Mol Sci, 2023 Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in various biological tissues, including the kidney, lung, and colon. They enable the selective reabsorption of sodium ions, which is a process critical for controlling blood pressure, electrolyte balance, and overall fluid volume. ENaC activity is finely controlled
Aufy M +4 more
europepmc +5 more sources
mTORC2, a Novel " Twist " on the Epithelial Sodium Channel (ENaC).
J Am Soc Nephrol, 2023 Ellison DH, Ellison DH, McCormick JA.
europepmc +3 more sources
Expression profiles of SGK-1 and α-ENaC in minor salivary glands of subjects with xerostomia [PDF]
Frontiers in Dental MedicineIntroductionEpithelial sodium channel (ENaC) is a major conduit for sodium transport across the cell membrane, and its activity is regulated by multiple factors/mechanisms, including the serum and glucocorticoid-regulated kinase-1 (SGK-1).
Mahmood S. Mozaffari, Rafik Abdelsayed
doaj +2 more sources
The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate. [PDF]
Biochem J, 2016 The thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC) are two of the most important determinants of salt balance and thus systemic blood pressure. Abnormalities in either result in profound changes in blood pressure.
Mistry AC +16 more
europepmc +4 more sources
Biochemistry and Biophysics Reports, 2023 Kokumi taste-active compounds enhance salty taste perception. In animal models, sodium (salt) detection is mediated by the amiloride-sensitive epithelial sodium channel, ENaC.
Albertino Bigiani, MeeRa Rhyu
doaj +1 more source
Reduced expression of Enac in Placenta tissues of patients with severe preeclampsia is related to compromised trophoblastic cell migration and invasion during pregnancy. [PDF]
PLoS ONE, 2013 The purpose of the study is to investigate the expression of epithelial sodium channel (ENaC) in normal pregnancy and severe preeclampsia placenta and to explore the underlying mechanism of the relationship between the altered ENaC expression and onset ...
Shan Wang +7 more
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Scientific Reports, 2021 Activity of the Epithelial Na+ Channel (ENaC) in the distal nephron fine-tunes renal sodium excretion. Appropriate sodium excretion is a key factor in the regulation of blood pressure.
Tarek Mohamed Abd El-Aziz +7 more
doaj +1 more source
Proteases, cystic fibrosis and the epithelial sodium channel (ENaC) [PDF]
Cell and Tissue Research, 2012 Proteases perform a diverse array of biological functions. From simple peptide digestion for nutrient absorption to complex signaling cascades, proteases are found in organisms from prokaryotes to humans. In the human airway, proteases are associated with the regulation of the airway surface liquid layer, tissue remodeling, host defense and pathogenic ...
P H, Thibodeau, M B, Butterworth
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The heterotetrameric architecture of the epithelial sodium channel (ENaC) [PDF]
The EMBO Journal, 1998 The epithelial sodium channel (ENaC) is a key element for the maintenance of sodium balance and the regulation of blood pressure. Three homologous ENaC subunits (alpha, beta and gamma) assemble to form a highly Na+-selective channel. However, the subunit stoichiometry of ENaC has not yet been solved.
D, Firsov +4 more
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