Results 21 to 30 of about 14,256 (219)

Recording Sodium Self-Inhibition of Epithelial Sodium Channels Using Automated Electrophysiology in Xenopus Oocytes

Membranes, 2023
The epithelial sodium channel (ENaC) is a key regulator of sodium homeostasis that contributes to blood pressure control. ENaC open probability is adjusted by extracellular sodium ions, a mechanism referred to as sodium self-inhibition (SSI).
Rene Y. Lawong, Fabian May, Etang C. Etang, Philipp Vorrat, Jonas George, Julia Weder, Dagmar Kockler, Matthias Preller, Mike Althaus   +8 more
doaj   +1 more source

Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption [PDF]

, 2020
The epithelial sodium channel (ENaC) can increase the colonic absorptive capacity for salt and water. Campylobacter concisus is a common pathogenic epsilonproteobacterium, causing enteritis and diarrhea. It can induce barrier dysfunction in the intestine,
Bereswill, Stefan, Butkevych, Eduard, Bücker, Roland, Fromm, Anja, Genger, Claudia, Heimesaat, Markus M., Kløve, Sigri, Lee, In-Fah Maria, Lobo de Sá, Fábia Daniela, Mousavi, Soraya, Nagel, Oliver, Nattramilarasu, Praveen Kumar, Nielsen, Hans Linde, Schulzke, Jörg-Dieter, Schweiger, Michal R., Troeger, Hanno   +15 more
core   +2 more sources

(Pro)Renin receptor mediates obesity-induced antinatriuresis and elevated blood pressure via upregulation of the renal epithelial sodium channel. [PDF]

PLoS ONE, 2018
Recent studies have demonstrated that the renal (pro)renin receptor (PRR) regulates expression of the alpha subunit of the epithelial sodium channel (α-ENaC).
Syed S Quadri, Silas Culver, Nrupama Ramkumar, Donald E Kohan, Helmy M Siragy   +4 more
doaj   +1 more source

Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?

Frontiers in Cardiovascular Medicine, 2022
Hypertension is a risk factor for end organ damage and death and is more common in persons with HIV compared to the general population. Several mechanisms have been studied in the pathogenesis of hypertension.
Katongo H. Mutengo, Katongo H. Mutengo, Sepiso K. Masenga, Sepiso K. Masenga, Naome Mwesigwa, Kaushik P. Patel, Annet Kirabo   +6 more
doaj   +1 more source

Cleavage of endogenous gamma ENaC and elevated abundance of alpha ENaC are associated with increased Na+ transport in response to apical fluid volume expansion in human H441 airway epithelial cells [PDF]

, 2011
Using human H441 airway epithelial cells cultured at air–liquid interface (ALI), we have uniquely correlated the functional response to apical fluid volume expansion with the abundance and cleavage of endogenous α- and γENaC proteins in the apical ...
Baines, DL, Selvanathar, IA, Tan, CD
core   +2 more sources

High glucose up-regulates ENaC and SGK1 expression in HCD-cells [PDF]

, 2006
Background/Aim: Diabetic nephropathy is associated with progressive renal damage, leading to impaired function and end-stage renal failure. Secondary hypertension stems from a deranged ability of cells within the kidney to resolve and appropriately ...
Bell LM, Bhargava A, Bland R, Christensen O, Claire Hills, Demerdash TM, Di Paolo S, Hoffman BB, Hong-Long JI, Jeanette Bennett, Khan ZA, Lang F, Lee CT, Lindschau C, Loffing J, Marshall SM, Paul Squires, Pierre Ronco, Prie D, Ricci C, Rosemary Bland, Rossier, Satlin LM, Sharma K, Symonian M, Urbach V, Waldegger S, Wang J, Weigert C, Whiteside CI, Yung S   +30 more
core   +1 more source

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
core   +1 more source

The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis. [PDF]

Curr Opin Pharmacol, 2018
Cystic fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR dysfunction is characterized by abnormal mucociliary transport due to a dehydrated airway surface liquid (ASL) and hyperviscous mucus, among other pathologies of host defense.
Shei RJ, Peabody JE, Kaza N, Rowe SM.
europepmc   +4 more sources

Anionic Phospholipids Regulate Native and Expressed Epithelial Sodium Channel (ENaC) [PDF]

Journal of Biological Chemistry, 2002
Using patch clamp techniques, we found that the epithelial sodium channel (ENaC) activity in the apical membrane of A6 distal nephron cells showed a sudden rundown beginning at 4 min after forming the inside-out configuration. This sudden rundown was prevented by addition of anionic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP(2 ...
He-Ping, Ma, Sunil, Saxena, David G, Warnock   +2 more
openaire   +2 more sources

PIP₂ Interacts Electrostatically with MARCKS-like Protein-1 and ENaC in Renal Epithelial Cells

Biology, 2022
We examined the interaction of a membrane-associated protein, MARCKS-like Protein-1 (MLP-1), and an ion channel, Epithelial Sodium Channel (ENaC), with the anionic lipid, phosphatidylinositol 4, 5-bisphosphate (PIP2).
Qiang Yue, Otor Al-Khalili, Auriel Moseley, Masaaki Yoshigi, Brandi Michele Wynne, Heping Ma, Douglas C. Eaton   +6 more
doaj   +1 more source