Results 31 to 40 of about 14,256 (219)
Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E. +3 more
core +2 more sources
Epithelial sodium channel (ENaC) and pregnancy
The FASEB Journal, 2009 A healthy pregnancy requires avid retention of sodium (Na) and plasma volume expansion (PVE) in order to provide adequate blood supply to the growing fetus. We performed in vivo and in vitro studies to
Crystal West +3 more
openaire +1 more source
Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia
Hypertension in Pregnancy, 2023 Objective To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls.
P.Y.M. Leung +9 more
doaj +1 more source
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E +3 more
core +3 more sources
Epithelial sodium channel (ENaC) in GtoPdb v.2021.2
IUPHAR/BPS Guide to Pharmacology CITE, 2021 The epithelial sodium channels (ENaC) are located on the apical membrane of epithelial cells in the kidney tubules, lung, respiratory tract, male and female reproductive tracts, sweat and salivary glands, placenta, colon, and some other organs [9, 13, 22, 21, 42].
openaire +2 more sources
High salt intake down-regulates colonic mineralocorticoid receptors, epithelial sodium channels and 11β-hydroxysteroid dehydrogenase type 2. [PDF]
PLoS ONE, 2012 Besides the kidneys, the gastrointestinal tract is the principal organ responsible for sodium homeostasis. For sodium transport across the cell membranes the epithelial sodium channel (ENaC) is of pivotal relevance.
Daniel Lienhard +4 more
doaj +1 more source
ADMET and DMPK, 2023 The epithelial sodium channel (ENaC) is a transmembrane protein that regulates the balance of sodium salt levels in the body through its expression in various tissues. The increase in sodium salt in the body is related to the expression of ENaC, thereby
Tias Febriana Hanifa Lestari +4 more
doaj +1 more source
Epithelial sodium channel (ENaC) in GtoPdb v.2023.1
IUPHAR/BPS Guide to Pharmacology CITE, 2023 OverviewThe epithelial sodium channels (ENaC) are located on the apical membrane of epithelial cells in the kidney tubules, lung, respiratory tract, male and female reproductive tracts, sweat and salivary glands, placenta, colon, and some other organs [10, 48, 14, 23, 22].
openaire +1 more source
Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity
Cell Reports, 2017 The homeostatic control of presynaptic neurotransmitter release stabilizes information transfer at synaptic connections in the nervous system of organisms ranging from insect to human. Presynaptic homeostatic signaling centers upon the regulated membrane
Brian O. Orr +5 more
doaj +1 more source
Iron Inhibits the Translation and Activity of the Renal Epithelial Sodium Channel
Biology, 2022 Hypertension is associated with an increased renal expression and activity of the epithelial sodium channel (ENaC) and iron deficiency. Distal tubules absorb iron, causing perturbations that may influence local responses.
Abdel A. Alli +8 more
doaj +1 more source