Results 51 to 60 of about 14,256 (219)
Molecules, 2022 THz spectroscopy is important for the study of ion channels because it directly addresses the low frequency collective motions relevant for their function. Here we used THz spectroscopy to investigate the inhibition of the epithelial sodium channel (ENaC)
Maria Mernea +7 more
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Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]
, 2000 Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
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Role of epithelial sodium channels (ENaCs) in endothelial function [PDF]
Journal of Cell Science, 2015 An increasing number of mechano-sensitive ion channels in endothelial cells (ECs) have been identified in response to blood flow and hydrostatic pressure. However, how these channels response to flow under different physiological and pathological conditions remains unknown. Our results showed that ENaCs were co-localized with hemeoxygenase-1 (HO-1) and
Dongqing Guo +10 more
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Journal of Pharmacological Sciences, 2022 Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic ...
Ryunosuke Nakashima +14 more
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Pseudohypoaldosteronism type 1 due to novel variants of SCNN1B gene. [PDF]
, 2016 UnlabelledAutosomal recessive pseudohypoaldosteronism type 1 (PHA1) is a rare disorder characterized by sodium wasting, failure to thrive, hyperkalemia, hypovolemia and metabolic acidosis.
Abraham, Smita B +9 more
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Epithelial Sodium Channel (ENaC) Trafficking and COMMD Proteins
The FASEB Journal, 2019 The epithelial sodium channel (ENaC), is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ and is selectively permeable to Na + ions and plays an essential role in the regulation of sodium transport in the renal connecting tubule and collecting duct. Mutations
Sahib Rasulov +2 more
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Frontiers in Physiology, 2022 The mechanistic target of rapamycin (mTOR), a serine-threonine-specific kinase, is a cellular energy sensor, integrating growth factor and nutrient signaling.
Bruce Chen +6 more
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Detection of Urinary Epithelial Sodium Channel (ENaC) Protein
American Journal of Clinical Medicine Research, 2018 Epithelial sodium Channel (ENaC) protein is an important substance in maintaining plasma sodium level. Its DNA sequences are similar in rat model with and without salt sensitivity, but the mRNA number increase in salt sensitive rat model with high salt diet. This condition is assumed to be similar in human.
Yulia Sofiatin, Rully MA Roesli
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Mechanosensitivity of the Epithelial Sodium Channel (ENaC): Controversy or Pseudocontroversy? [PDF]
The Journal of General Physiology, 1998 Amiloride-sensitive epithelial sodium channels constitute the rate-limiting step for sodium reabsorption in the distal part of the renal tubule, in the distal colon, in the ducts of several exocrine glands, and in the airways (Rossier et al., 1994).
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The epidthelial sodium channel ENaC and its regulators in the epidermal permeability barrier function [PDF]
, 2010 The highly amiloride-sensitive epithelial sodium channel ENaC is well known to be involved in controlling whole body sodium homeostasis and lung liquid clearance. ENaC expression has also been detected in the skin of amphibians and mammals.
Charles, R-P. +2 more
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